{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:51:14Z","timestamp":1790664674328,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP137090"],"award-info":[{"award-number":["MOP137090"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-155990"],"award-info":[{"award-number":["PJT-155990"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.heliyon.2019.e01498","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T20:28:57Z","timestamp":1555360137000},"page":"e01498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-4588","authenticated-orcid":false,"given":"Nazanin","family":"Mohammadzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Arts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Art F.Y.","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chelico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2019.e01498_bib1","doi-asserted-by":"crossref","first-page":"40875","DOI":"10.1074\/jbc.R112.416925","article-title":"The restriction factors of human immunodeficiency virus","volume":"287","author":"Harris","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ni.3156","article-title":"Intrinsic host restrictions to HIV-1 and mechanisms of viral escape","volume":"16","author":"Simon","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003135","article-title":"Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses","volume":"9","author":"Compton","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chom.2011.11.010","article-title":"The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict","volume":"11","author":"Compton","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heliyon.2019.e01498_bib5","doi-asserted-by":"crossref","first-page":"20120496","DOI":"10.1098\/rstb.2012.0496","article-title":"Host gene evolution traces the evolutionary history of ancient primate lentiviruses","volume":"368","author":"Compton","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.heliyon.2019.e01498_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005304","article-title":"Evolutionary analyses suggest a function of MxB immunity proteins beyond lentivirus restriction","volume":"11","author":"Mitchell","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003496","article-title":"Evolutionary toggling of Vpx\/Vpr specificity results in divergent recognition of the restriction factor SAMHD1","volume":"9","author":"Fregoso","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chom.2013.06.002","article-title":"Gene loss and adaptation to hominids underlie the ancient origin of HIV-1","volume":"14","author":"Etienne","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heliyon.2019.e01498_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005958","article-title":"Evolutionary paradigms from ancient and ongoing conflicts between the lentiviral vif protein and mammalian APOBEC3 enzymes","volume":"12","author":"Harris","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12977-017-0355-4","article-title":"A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif","volume":"14","author":"Nakano","year":"2017","journal-title":"Retrovirology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cytogfr.2018.02.005","article-title":"Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins","volume":"40","author":"Sauter","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.heliyon.2019.e01498_bib12","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1128\/AAC.00137-15","article-title":"Incomplete APOBEC3G\/F neutralization by HIV-1 Vif mutants facilitates the genetic evolution from CCR5 to CXCR4 usage","volume":"59","author":"Alteri","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heliyon.2019.e01498_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nri3295","article-title":"Evolutionary conflicts between viruses and restriction factors shape immunity","volume":"12","author":"Duggal","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000367","article-title":"Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance","volume":"5","author":"Jern","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.20091933","article-title":"The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells","volume":"207","author":"Casartelli","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.heliyon.2019.e01498_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12981-017-0173-8","article-title":"Evasion of adaptive immunity by HIV through the action of host APOBEC3G\/F enzymes","volume":"14","author":"Grant","year":"2017","journal-title":"AIDS Res. Ther."},{"key":"10.1016\/j.heliyon.2019.e01498_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1021\/acsinfecdis.7b00221","article-title":"Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates","volume":"4","author":"Adolph","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.heliyon.2019.e01498_bib18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fmicb.2014.00450","article-title":"Suppression of APOBEC3-mediated restriction of HIV-1 by Vif","volume":"5","author":"Feng","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib19","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jmb.2013.10.033","article-title":"Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all","volume":"426","author":"Desimmie","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature10693","article-title":"Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection","volume":"481","author":"Jager","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2019.e01498_bib21","article-title":"Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFbeta and CRL5 E3 ubiquitin ligase components","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2019.e01498_bib22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature10718","article-title":"T-cell differentiation factor CBF-beta regulates HIV-1 Vif-mediated evasion of host restriction","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2019.e01498_bib23","doi-asserted-by":"crossref","first-page":"8656","DOI":"10.1128\/JVI.00767-08","article-title":"Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly","volume":"82","author":"Stanley","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib24","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1101\/gad.1250204","article-title":"Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines","volume":"18","author":"Yu","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.heliyon.2019.e01498_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000925","article-title":"The SOCS-box of HIV-1 Vif interacts with Elongin BC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex","volume":"6","author":"Bergeron","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature12884","article-title":"Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif","volume":"505","author":"Guo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2019.e01498_bib27","doi-asserted-by":"crossref","first-page":"19539","DOI":"10.1073\/pnas.0906652106","article-title":"HIV-1 Vif-mediated ubiquitination\/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain","volume":"106","author":"Iwatani","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2019.e01498_bib28","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jmb.2013.01.010","article-title":"Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F","volume":"425","author":"Albin","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005833","article-title":"The RNA binding specificity of human APOBEC3 proteins resembles that of HIV-1 nucleocapsid","volume":"12","author":"York","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004609","article-title":"Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1","volume":"11","author":"Apolonia","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib31","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/nsmb.1495","article-title":"Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase","volume":"15","author":"Nowarski","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib32","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nsmb.2378","article-title":"The APOBEC3C crystal structure and the interface for HIV-1 Vif binding","volume":"19","author":"Kitamura","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib33","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/JVI.02369-15","article-title":"Structural insights into HIV-1 vif-APOBEC3F interaction","volume":"90","author":"Nakashima","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib34","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.jmb.2017.03.019","article-title":"Mapping region of human restriction factor APOBEC3H critical for interaction with HIV-1 vif","volume":"429","author":"Nakashima","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02289-16","article-title":"The structural interface between HIV-1 vif and human APOBEC3H","volume":"91","author":"Ooms","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib36","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.celrep.2015.10.068","article-title":"Identification of the HIV-1 vif and human APOBEC3G protein interface","volume":"13","author":"Letko","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.heliyon.2019.e01498_bib37","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.celrep.2015.10.067","article-title":"The binding interface between human APOBEC3F and HIV-1 vif elucidated by genetic and computational approaches","volume":"13","author":"Richards","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.heliyon.2019.e01498_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006830","article-title":"Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors","volume":"14","author":"Binning","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib39","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1128\/JVI.02694-06","article-title":"Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant","volume":"81","author":"Opi","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib40","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jmb.2011.03.058","article-title":"Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif","volume":"410","author":"Britan-Rosich","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib41","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1074\/jbc.M112.421875","article-title":"HIV-1 viral infectivity factor (Vif) alters processive single-stranded DNA scanning of the retroviral restriction factor APOBEC3G","volume":"288","author":"Feng","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib42","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.4156","article-title":"Defective proviruses rapidly accumulate during acute HIV-1 infection","volume":"22","author":"Bruner","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.heliyon.2019.e01498_bib43","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1017\/S1462399409001343","article-title":"Interactions of host APOBEC3 restriction factors with HIV-1 in\u00a0vivo: implications for therapeutics","volume":"12","author":"Albin","year":"2010","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.heliyon.2019.e01498_bib44","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.ppat.0010006","article-title":"Natural variation in Vif: differential impact on APOBEC3G\/3F and a potential role in HIV-1 diversification","volume":"1","author":"Simon","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib45","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1097\/QAD.0b013e32833e515a","article-title":"Partially active HIV-1 Vif alleles facilitate viral escape from specific antiretrovirals","volume":"24","author":"Fourati","year":"2010","journal-title":"Aids"},{"key":"10.1016\/j.heliyon.2019.e01498_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virol.2015.03.012","article-title":"APOBECs and virus restriction","volume":"479\u2013480","author":"Harris","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib47","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/nar\/gkl555","article-title":"Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication","volume":"34","author":"Suspene","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib48","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1128\/JVI.00723-10","article-title":"The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G\/F","volume":"84","author":"Hu","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib49","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1128\/JVI.80.7.3679-3683.2006","article-title":"Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B","volume":"80","author":"Wurtzer","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004024","article-title":"Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms","volume":"10","author":"Ara","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib51","doi-asserted-by":"crossref","first-page":"27188","DOI":"10.1074\/jbc.M115.666065","article-title":"Natural polymorphisms and oligomerization of human APOBEC3H contribute to single-stranded DNA scanning ability","volume":"290","author":"Feng","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib52","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1093\/nar\/gkx066","article-title":"Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization","volume":"45","author":"Adolph","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib53","doi-asserted-by":"crossref","first-page":"11220","DOI":"10.1128\/JVI.05238-11","article-title":"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1","volume":"85","author":"Hultquist","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib54","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1128\/JVI.78.20.11070-11076.2004","article-title":"APOBEC3G genetic variants and their influence on the progression to AIDS","volume":"78","author":"An","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005921","article-title":"Role of APOBEC3F gene variation in HIV-1 disease progression and pneumocystis pneumonia","volume":"12","author":"An","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.heliyon.2019.e01498_bib56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/JVI.01665-08","article-title":"Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H","volume":"83","author":"Harari","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib57","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.chom.2013.09.006","article-title":"HIV-1 Vif adaptation to human APOBEC3H haplotypes","volume":"14","author":"Ooms","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heliyon.2019.e01498_bib58","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1097\/QAD.0000000000001113","article-title":"Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes","volume":"30","author":"Reddy","year":"2016","journal-title":"AIDS"},{"key":"10.1016\/j.heliyon.2019.e01498_bib59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2008.07.005","article-title":"Antiretroelement activity of APOBEC3H was lost twice in recent human evolution","volume":"4","author":"OhAinle","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heliyon.2019.e01498_bib60","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.virol.2013.05.016","article-title":"Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations","volume":"443","author":"Duggal","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib61","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1128\/JVI.02049-10","article-title":"Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity","volume":"85","author":"Wang","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005865","article-title":"A single nucleotide polymorphism in human APOBEC3C enhances restriction of lentiviruses","volume":"12","author":"Wittkopp","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib63","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nsmb758","article-title":"Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome","volume":"11","author":"Yu","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib64","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1099\/vir.0.000214","article-title":"Comparative analysis of the gene-inactivating potential of retroviral restriction factors APOBEC3F and APOBEC3G","volume":"96","author":"Belanger","year":"2015","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib65","doi-asserted-by":"crossref","first-page":"7848","DOI":"10.1093\/nar\/gkw653","article-title":"APOBEC3 proteins can copackage and comutate HIV-1 genomes","volume":"44","author":"Desimmie","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib66","first-page":"91","article-title":"Mechanism of enhanced HIV restriction by virion coencapsidated cytidine deaminases APOBEC3F and APOBEC3G","author":"Ara","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005646","article-title":"Minimal contribution of APOBEC3-induced G-to-A hypermutation to HIV-1 recombination and genetic variation","volume":"12","author":"Delviks-Frankenberry","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib68","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1073\/pnas.0710190105","article-title":"Cytidine deamination induced HIV-1 drug resistance","volume":"105","author":"Mulder","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2019.e01498_bib69","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.chom.2017.03.008","article-title":"Defective HIV-1 proviruses are expressed and can be recognized by cytotoxic T lymphocytes, which shape the proviral landscape","volume":"21","author":"Pollack","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heliyon.2019.e01498_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004281","article-title":"Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection","volume":"10","author":"Kim","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib71","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1128\/JVI.01223-10","article-title":"Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure","volume":"84","author":"Kim","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2005.12.035","article-title":"Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates","volume":"349","author":"Zennou","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib73","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/JVI.00676-12","article-title":"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages","volume":"87","author":"Chaipan","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004453","article-title":"APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model","volume":"10","author":"Sato","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-4690-9-35","article-title":"Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment","volume":"9","author":"Monajemi","year":"2012","journal-title":"Retrovirology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093428","article-title":"Positioning of APOBEC3G\/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells","volume":"9","author":"Monajemi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2019.e01498_bib77","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/QAI.0000000000000689","article-title":"Impact of APOBEC mutations on CD8+ T cell recognition of HIV epitopes varies depending on the restricting HLA","volume":"70","author":"Squires","year":"2015","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.heliyon.2019.e01498_bib78","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1097\/QAD.0b013e3283560703","article-title":"E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure","volume":"26","author":"Fourati","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.heliyon.2019.e01498_bib79","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/jac\/dks219","article-title":"HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs","volume":"67","author":"Fourati","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.heliyon.2019.e01498_bib80","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/QAD.0000000000000182","article-title":"Differential impact of APOBEC3-driven mutagenesis on HIV evolution in diverse anatomical compartments","volume":"28","author":"Fourati","year":"2014","journal-title":"Aids"},{"key":"10.1016\/j.heliyon.2019.e01498_bib81","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1128\/JVI.00554-08","article-title":"Comparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants","volume":"82","author":"Knoepfel","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib82","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1128\/AAC.01029-13","article-title":"Basis for early and preferential selection of the E138K mutation in HIV-1 reverse transcriptase","volume":"57","author":"McCallum","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heliyon.2019.e01498_bib83","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmi.2015.10.004","article-title":"Contribution of APOBEC3G\/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type 1 variants","volume":"22","author":"Noguera-Julian","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.heliyon.2019.e01498_bib84","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-4690-6-16","article-title":"APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA","volume":"6","author":"Russell","year":"2009","journal-title":"Retrovirology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib85","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1021\/bi00119a002","article-title":"Fidelity of HIV-1 reverse transcriptase copying RNA in\u00a0vitro","volume":"31","author":"Ji","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.heliyon.2019.e01498_bib86","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1128\/JVI.00915-10","article-title":"Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication","volume":"84","author":"Abram","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib87","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1128\/jvi.69.8.5087-5094.1995","article-title":"Lower in\u00a0vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase","volume":"69","author":"Mansky","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib88","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1093\/nar\/gkq174","article-title":"Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction","volume":"38","author":"Refsland","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib89","doi-asserted-by":"crossref","first-page":"9474","DOI":"10.1128\/JVI.01089-09","article-title":"Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets","volume":"83","author":"Koning","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib90","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virol.2018.11.004","article-title":"Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies","volume":"527","author":"Mohammadzadeh","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib91","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1093\/nar\/gkt246","article-title":"APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure","volume":"41","author":"Holtz","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib92","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1074\/jbc.M807258200","article-title":"Dissecting APOBEC3G substrate specificity by nucleoside analog interference","volume":"284","author":"Rausch","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib93","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41564-017-0063-9","article-title":"Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G","volume":"3","author":"Pollpeter","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib94","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1093\/nar\/gkm750","article-title":"Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G","volume":"35","author":"Iwatani","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib95","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1128\/JVI.02630-09","article-title":"Moderate influence of human APOBEC3F on HIV-1 replication in primary lymphocytes","volume":"84","author":"Mulder","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib96","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.virol.2015.05.020","article-title":"Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients","volume":"484","author":"Dunn","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib97","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1128\/jvi.71.10.7478-7487.1997","article-title":"Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype","volume":"71","author":"Bjorndal","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib98","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1128\/JVI.01249-10","article-title":"Stably expressed APOBEC3F has negligible antiviral activity","volume":"84","author":"Miyagi","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib99","doi-asserted-by":"crossref","first-page":"11415","DOI":"10.1074\/jbc.M110.199604","article-title":"Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain","volume":"286","author":"Feng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.virol.2009.02.026","article-title":"Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent","volume":"387","author":"Browne","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003242","article-title":"HIV restriction by APOBEC3 in humanized mice","volume":"9","author":"Krisko","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib102","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.cub.2004.06.050","article-title":"APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in\u00a0vivo","volume":"14","author":"Liddament","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib103","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1128\/JVI.00823-10","article-title":"Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice","volume":"84","author":"Sato","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002800","article-title":"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n","volume":"8","author":"Refsland","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib105","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1074\/jbc.M710148200","article-title":"Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect","volume":"283","author":"Gao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e01498_bib106","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1128\/JVI.05584-11","article-title":"Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I\/V mutations","volume":"85","author":"Xu","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib107","doi-asserted-by":"crossref","first-page":"8448","DOI":"10.1128\/JVI.73.10.8448-8456.1999","article-title":"Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val","volume":"73","author":"Sharma","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib108","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/jmbi.1998.1624","article-title":"Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase","volume":"277","author":"Gao","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib109","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1002\/j.1460-2075.1996.tb00777.x","article-title":"Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme","volume":"15","author":"Back","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.heliyon.2019.e01498_bib110","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1128\/AAC.39.7.1624","article-title":"Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1","volume":"39","author":"Boyer","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heliyon.2019.e01498_bib111","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/COH.0b013e3283454cf5","article-title":"HIV-1 replicative fitness in elite controllers","volume":"6","author":"Lobritz","year":"2011","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.heliyon.2019.e01498_bib112","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11904-007-0006-9","article-title":"The impact of viral and host elements on HIV fitness and disease progression","volume":"4","author":"Henry","year":"2007","journal-title":"Curr. HIV AIDS Rep."},{"key":"10.1016\/j.heliyon.2019.e01498_bib113","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/viro.1995.1547","article-title":"Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread","volume":"213","author":"Toohey","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2019.e01498_bib114","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/meth.1997.0481","article-title":"p24 Antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents","volume":"12","author":"Wehrly","year":"1997","journal-title":"Methods"},{"key":"10.1016\/j.heliyon.2019.e01498_bib115","doi-asserted-by":"crossref","first-page":"14380","DOI":"10.1128\/JVI.02484-14","article-title":"Determinants of efficient degradation of APOBEC3 restriction factors by HIV-1 Vif","volume":"88","author":"Baig","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib116","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1128\/jvi.71.7.5259-5267.1997","article-title":"The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells","volume":"71","author":"Simon","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib117","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/jvi.69.7.4166-4172.1995","article-title":"Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes","volume":"69","author":"Simon","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib118","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1128\/jvi.70.12.8263-8269.1996","article-title":"Human immunodeficiency virus type 1 Vif does not influence expression or virion incorporation of gag-, pol-, and env-encoded proteins","volume":"70","author":"Fouchier","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.heliyon.2019.e01498_bib119","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virusres.2016.12.008","article-title":"Promises and pitfalls of Illumina sequencing for HIV resistance genotyping","volume":"239","author":"Brumme","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.heliyon.2019.e01498_bib120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.heliyon.2019.e01498_bib121","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1371\/journal.ppat.0030015","article-title":"Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H","volume":"3","author":"Soros","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2019.e01498_bib122","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J","article-title":"Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia","volume":"18","author":"Foley","year":"1965","journal-title":"Cancer"},{"key":"10.1016\/j.heliyon.2019.e01498_bib123","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/nar\/gkg100","article-title":"Human immunodeficiency virus reverse transcriptase and protease sequence database","volume":"31","author":"Rhee","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"Suppl. 1","key":"10.1016\/j.heliyon.2019.e01498_bib124","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1086\/505356","article-title":"Rationale and uses of a public HIV drug-resistance database","volume":"194","author":"Shafer","year":"2006","journal-title":"J. Infect. Dis."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019300180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019300180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:38:24Z","timestamp":1762511904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844019300180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":124,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S2405844019300180"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01498","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e01498"}}