{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:14:38Z","timestamp":1785492878164,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.heliyon.2019.e01502","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T16:27:02Z","timestamp":1555086422000},"page":"e01502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of oxidative stress and the microenvironment in oral submucous fibrosis"],"prefix":"10.1016","volume":"5","author":[{"given":"Vertika","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satadal","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.heliyon.2019.e01502_bib1","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.4161\/cc.9.16.12553","article-title":"Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells","volume":"9","author":"Martinez-Outschoorn","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.heliyon.2019.e01502_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.archoralbio.2018.10.016","article-title":"Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using 1H nuclear magnetic resonance spectroscopy","volume":"97","author":"Rai","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.heliyon.2019.e01502_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.archoralbio.2017.12.003","article-title":"\u201cOmics\u201d in oral cancer: new approaches for biomarker discovery","volume":"87","author":"Rai","year":"2017","journal-title":"Arch. Oral Biol."},{"issue":"2","key":"10.1016\/j.heliyon.2019.e01502_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0021-9150(00)00499-8","article-title":"The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes","volume":"154","author":"Anderson","year":"2001","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.heliyon.2019.e01502_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.heliyon.2019.e01502_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.job.2018.08.002","article-title":"Evaluation of aberrant metabolism related proteins in oral submucous fibrosis: a pilot study","volume":"60","author":"Rai","year":"2018","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.heliyon.2019.e01502_bib7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.saa.2017.08.018","article-title":"Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry","volume":"189","author":"Rai","year":"2018","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.heliyon.2019.e01502_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbacli.2015.01.006","article-title":"Cancer metabolism and oxidative stress: insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate","volume":"3","author":"Hess","year":"2015","journal-title":"BBA Clin."},{"issue":"4","key":"10.1016\/j.heliyon.2019.e01502_bib9","first-page":"178","article-title":"Evaluating an alternative cost effective protocol to screen and detect oral pre-cancerous and cancerous lesions","volume":"3","author":"Bose","year":"2017","journal-title":"IJADS"},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of cancer metabolism","volume":"2","author":"DeBerardinis","year":"2016","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e01502_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.oraloncology.2013.09.011","article-title":"Oxidative and antioxidative mechanisms in oral cancer and precancer: a review","volume":"50","author":"Choudhari","year":"2014","journal-title":"Oral Oncol."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/met.2010.0140","article-title":"Oxidative stress is activated by free fatty acids in cultured human hepatocytes","volume":"9","author":"Soardo","year":"2011","journal-title":"Metab. Syndr. Relat. Disord."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00423-006-0073-1","article-title":"Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair","volume":"391","author":"Bartsch","year":"2006","journal-title":"Langenbeck's Arch. Surg."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e01502_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.heliyon.2019.e01502_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.HYP.0000258594.87211.6b","article-title":"Measurement of reactive oxygen species in cardiovascular studies","volume":"49","author":"Dikalov","year":"2007","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tibs.2016.02.003","article-title":"Intermediates of metabolism: from bystanders to signalling molecules","volume":"41","author":"Haas","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"S1","key":"10.1016\/j.heliyon.2019.e01502_bib17","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1186\/1744-859X-7-S1-S86","article-title":"Fatty acids and oxidative stress","volume":"7","author":"Tsaluchidu","year":"2008","journal-title":"Ann. Gen. Psychiatr."},{"issue":"10","key":"10.1016\/j.heliyon.2019.e01502_bib18","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/meta.2002.35200","article-title":"Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress","volume":"51","author":"Piro","year":"2002","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.heliyon.2019.e01502_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fct.2014.12.005","article-title":"Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in\u00a0vitro model","volume":"76","author":"Hern\u00e1ndez","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e01502_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/07315724.2003.10719272","article-title":"Vitamin C as an antioxidant: evaluation of its role in disease prevention","volume":"22","author":"Padayatty","year":"2003","journal-title":"J. Am. Coll. Nutr."},{"issue":"4","key":"10.1016\/j.heliyon.2019.e01502_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/imm.12659","article-title":"The contribution of the citrate pathway to oxidative stress in down syndrome","volume":"149","author":"Convertini","year":"2016","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.heliyon.2019.e01502_bib22","first-page":"395","article-title":"Oxidative stress-mediated biomolecular damage and inflammation in tumorigenesis","volume":"26","author":"Sesti","year":"2012","journal-title":"In\u00a0Vivo"},{"issue":"4","key":"10.1016\/j.heliyon.2019.e01502_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1530\/rep.0.1220497","article-title":"Oxidative stress, DNA damage and the Y chromosome","volume":"122","author":"Aitken","year":"2001","journal-title":"Reproduction"},{"issue":"12","key":"10.1016\/j.heliyon.2019.e01502_bib24","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.87.12.4533","article-title":"Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine","volume":"87","author":"Fraga","year":"1990","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.heliyon.2019.e01502_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fonc.2018.00015","article-title":"DNA damage, repair, and cancer metabolism","volume":"8","author":"Turgeon","year":"2018","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.heliyon.2019.e01502_bib26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jvs.2004.07.044","article-title":"Serum total 8-iso-prostaglandin F2\u03b1: a new and independent predictor of peripheral arterial disease","volume":"40","author":"Mueller","year":"2004","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.heliyon.2019.e01502_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.freeradbiomed.2016.03.001","article-title":"Reinterpreting the best biomarker of oxidative stress: the 8-iso-prostaglandin F2\u03b1\/prostaglandin F2\u03b1 ratio shows complex origins of lipid peroxidation biomarkers in animal models","volume":"95","author":"van't Erve","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1\u20132","key":"10.1016\/j.heliyon.2019.e01502_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0014-5793(98)00481-5","article-title":"Metabolism of 8-iso-prostaglandin F2\u03b1","volume":"428","author":"Basu","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.heliyon.2019.e01502_bib29","first-page":"2012","article-title":"Oxidative stress and lipid peroxidation products in cancer progression and therapy","author":"Barrera","year":"2012","journal-title":"ISRN Oncol."},{"issue":"1\u20132","key":"10.1016\/j.heliyon.2019.e01502_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0009-8981(03)00003-2","article-title":"Protein carbonyl groups as biomarkers of oxidative stress","volume":"329","author":"Dalle-Donne","year":"2003","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.heliyon.2019.e01502_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0891-5849(97)00104-4","article-title":"Protein carbonyl measurement by a sensitive ELISA method","volume":"23","author":"Buss","year":"1997","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.heliyon.2019.e01502_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194164","article-title":"Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue","volume":"13","author":"Aryal","year":"2018","journal-title":"PLoS One"},{"issue":"33","key":"10.1016\/j.heliyon.2019.e01502_bib33","doi-asserted-by":"crossref","first-page":"20313","DOI":"10.1074\/jbc.272.33.20313","article-title":"Protein oxidation in aging, disease, and oxidative stress","volume":"272","author":"Berlett","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1155\/2009\/545896","article-title":"Protein oxidation in breast microenvironment: nipple aspirate fluid collected from breast cancer women contains increased protein carbonyl concentration","volume":"31","author":"Mannello","year":"2009","journal-title":"Anal. Cell Pathol."},{"key":"10.1016\/j.heliyon.2019.e01502_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.redox.2017.08.009","article-title":"Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer","volume":"14","author":"Andrisic","year":"2018","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.heliyon.2019.e01502_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular fatty acid metabolism and cancer","volume":"18","author":"Currie","year":"2013","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib37","first-page":"778","article-title":"Lipid metabolism and carcinogenesis, cancer development","volume":"8","author":"Long","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"9","key":"10.1016\/j.heliyon.2019.e01502_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1360-1385(02)02312-9","article-title":"Oxidative stress, antioxidants and stress tolerance","volume":"7","author":"Mittler","year":"2002","journal-title":"Trends Plant Sci."},{"issue":"8","key":"10.1016\/j.heliyon.2019.e01502_bib39","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0009-9120(01)00270-3","article-title":"Plasma ascorbic acid: measurement, stability and clinical utility revisited","volume":"34","author":"Chung","year":"2001","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.heliyon.2019.e01502_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fphys.2015.00397","article-title":"Vitamin C in health and disease: its role in the metabolism of cells and redox state in the brain","volume":"6","author":"Figueroa-M\u00e9ndez","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.heliyon.2019.e01502_bib41","series-title":"Metabolism Consist of Highly Interconnected Pathways","author":"Berg","year":"2002"},{"issue":"2","key":"10.1016\/j.heliyon.2019.e01502_bib42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e01502_bib43","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1582-4934.2007.00097.x","article-title":"Plasma protein carbonyl levels and breast cancer risk","volume":"11","author":"Rossner","year":"2007","journal-title":"J. Cell Mol. Med."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019305146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019305146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:25:47Z","timestamp":1762511147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844019305146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S2405844019305146"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01502","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of oxidative stress and the microenvironment in oral submucous fibrosis","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e01502"}}