{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:42:22Z","timestamp":1762512142265,"version":"build-2065373602"},"reference-count":19,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001455","name":"American Foundation for Suicide Prevention","doi-asserted-by":"publisher","award":["DIG-0-087-13"],"award-info":[{"award-number":["DIG-0-087-13"]}],"id":[{"id":"10.13039\/100001455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.heliyon.2019.e01709","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T08:19:06Z","timestamp":1557562746000},"page":"e01709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-7858","authenticated-orcid":false,"given":"William Vaughn","family":"McCall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anilkumar","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirayu D.","family":"Pandya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laryssa","family":"McCloud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Moraczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liniya","family":"Tauhidul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagy A.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Case","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Rosenquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2019.e01709_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2009.03.044","article-title":"Noradrenergic and serotonergic mechanisms in the Neurobiology of posttraumatic stress disorder and resilience","volume":"1293","author":"Krystal","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.heliyon.2019.e01709_bib2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/japplphysiol.00470.2003","article-title":"Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system","volume":"96","author":"Vallbo","year":"2004","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.heliyon.2019.e01709_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.psyneuen.2009.01.014","article-title":"Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research","volume":"34","author":"Nater","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.heliyon.2019.e01709_bib4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.psyneuen.2011.09.013","article-title":"Altered salivary alpha-amylase awakening response in Bosnian War refugees with posttraumatic stress disorder","volume":"37","author":"Thoma","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.heliyon.2019.e01709_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.nlm.2013.11.018","article-title":"Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder","volume":"112","author":"Nicholson","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.heliyon.2019.e01709_bib6","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1177\/0269881109105899","article-title":"Effects of modafinil and prazosin on cognitive and physiologic functions in health volunteers","volume":"24","author":"Winder-Rhodes","year":"2010","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.heliyon.2019.e01709_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.psyneuen.2014.07.023","article-title":"Norepineprine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men","volume":"49","author":"Kuebler","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.heliyon.2019.e01709_bib8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/JCP.0000000000000968","article-title":"A\u00a0pilot, randomized clinical trial of bedtime doses of prazosin versus placebo in suicidal posttruamatic stress disorder patients with nightmares","volume":"38","author":"McCall","year":"2018","journal-title":"J.\u00a0Clin. Psychopharmacol."},{"key":"10.1016\/j.heliyon.2019.e01709_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/da.1029","article-title":"Clinician-administered PTSD scale: a review of the first ten years of research","volume":"13","author":"Weathers","year":"2001","journal-title":"Depress. Anxiety"},{"year":"2013","series-title":"American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders","key":"10.1016\/j.heliyon.2019.e01709_bib10"},{"key":"10.1016\/j.heliyon.2019.e01709_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4088\/JCP.v63n0804","article-title":"Sleep dynamic therapy for Cerro Grande fire evacuees with posttraumatic stress symptoms: a preliminary report","volume":"63","author":"Krakow","year":"2002","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.heliyon.2019.e01709_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1037\/0022-006X.47.2.343","article-title":"Assessment of suicidal intention: the Scale for Suicide Ideation","volume":"47","author":"Beck","year":"1979","journal-title":"J.\u00a0Consult. Clin. Psychol."},{"key":"10.1016\/j.heliyon.2019.e01709_bib13","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/da.20837","article-title":"Synthesis of the psychometric properties of the PTSD checklist (PCL) military, civilian, and specific versions","volume":"28","author":"Wilkins","year":"2011","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.heliyon.2019.e01709_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med."},{"key":"10.1016\/j.heliyon.2019.e01709_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A\u00a0rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.heliyon.2019.e01709_bib16","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1176\/appi.ajp.2013.12081133","article-title":"A\u00a0trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan","volume":"170","author":"Raskind","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.heliyon.2019.e01709_bib17","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0003-9969(87)90123-3","article-title":"Temporal variations of glandular kallikrein, protein and amylase in mixed huma saliva","volume":"32","author":"Jenzano","year":"1987","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.heliyon.2019.e01709_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.psyneuen.2017.01.029","article-title":"Norepinephrine transporter blocker atomoxetine inceases salivary amylase","volume":"78","author":"Warren","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.heliyon.2019.e01709_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopsych.2005.09.023","article-title":"Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder","volume":"59","author":"Taylor","year":"2006","journal-title":"Biol. Psychiatry"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240584401836359X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240584401836359X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:37:53Z","timestamp":1762511873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240584401836359X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S240584401836359X"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01709","relation":{},"ISSN":["2405-8440"],"issn-type":[{"type":"print","value":"2405-8440"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e01709"}}