{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:49:03Z","timestamp":1778662143893,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.heliyon.2019.e02643","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T08:30:39Z","timestamp":1573720239000},"page":"e02643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-0595","authenticated-orcid":false,"given":"Pier Paolo","family":"Piccaluga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2830-9937","authenticated-orcid":false,"given":"Mohsen","family":"Navari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-1796","authenticated-orcid":false,"given":"Axel","family":"Visani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Rigotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-1422","authenticated-orcid":false,"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Righi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Diani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ligozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-6226","authenticated-orcid":false,"given":"Maria","family":"Carelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ponti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-5201","authenticated-orcid":false,"given":"Isabella","family":"Bon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-4144","authenticated-orcid":false,"given":"Donato","family":"Zipeto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo","family":"Landolfo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Gibellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2005.03.032","article-title":"The HIN-200 family: more than interferon-inducible genes?","volume":"308","author":"Ludlow","year":"2005","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/jir.2010.0106","article-title":"The multifaceted interferon-inducible p200 family proteins: from cell biology to human pathology","volume":"31","author":"Gariglio","year":"2011","journal-title":"J.\u00a0Interferon Cytokine Res."},{"issue":"52","key":"10.1016\/j.heliyon.2019.e02643_bib3","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1038\/sj.onc.1204005","article-title":"Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16","volume":"19","author":"Johnstone","year":"2000","journal-title":"Oncogene"},{"issue":"55","key":"10.1016\/j.heliyon.2019.e02643_bib4","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1038\/sj.onc.1207057","article-title":"A\u00a0member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway","volume":"22","author":"Aglipay","year":"2003","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.heliyon.2019.e02643_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1189\/jlb.0904507","article-title":"Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells","volume":"77","author":"Gugliesi","year":"2005","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"11","key":"10.1016\/j.heliyon.2019.e02643_bib6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"Unterholzner","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e02643_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","article-title":"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection","volume":"9","author":"Kerur","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.heliyon.2019.e02643_bib8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.str.2010.12.015","article-title":"Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53","volume":"19","author":"Liao","year":"2011","journal-title":"Structure"},{"issue":"4","key":"10.1016\/j.heliyon.2019.e02643_bib9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.immuni.2012.02.014","article-title":"Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor","volume":"36","author":"Jin","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.heliyon.2019.e02643_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pep.2014.07.004","article-title":"Bacterial expression of the HINab domain of IFI16: purification, characterization of DNA binding activity, and co-crystallization with viral dsDNA","volume":"102","author":"Liu","year":"2014","journal-title":"Protein Expr. Purif."},{"issue":"48","key":"10.1016\/j.heliyon.2019.e02643_bib11","doi-asserted-by":"crossref","first-page":"E4571","DOI":"10.1073\/pnas.1311669110","article-title":"IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication","volume":"110","author":"Jakobsen","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.heliyon.2019.e02643_bib12","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.4049\/jimmunol.1700385","article-title":"Cutting edge: genetic association between IFI16 single nucleotide polymorphisms and resistance to genital herpes correlates with IFI16 expression levels and HSV-2\u2013Induced IFN-\u03b2 expression","volume":"199","author":"Eriksson","year":"2017","journal-title":"J.\u00a0Immunol."},{"issue":"6169","key":"10.1016\/j.heliyon.2019.e02643_bib13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1243640","article-title":"IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV","volume":"343","author":"Monroe","year":"2014","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.heliyon.2019.e02643_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01553-16","article-title":"Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection","volume":"7","author":"Diner","year":"2016","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002498","article-title":"The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication","volume":"8","author":"Gariano","year":"2012","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib16","first-page":"5","article-title":"The interferon-inducible DNA-sensor protein IFI16: a key player in the antiviral response","volume":"38","author":"Dell'Oste","year":"2015","journal-title":"New Microbiol."},{"issue":"18","key":"10.1016\/j.heliyon.2019.e02643_bib17","doi-asserted-by":"crossref","first-page":"8238","DOI":"10.1128\/JVI.00923-16","article-title":"Regulatory interaction between the cellular restriction factor IFI16 and viral pp65 (pUL83) modulates viral gene expression and IFI16 protein stability","volume":"90","author":"Biolatti","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.heliyon.2019.e02643_bib18","doi-asserted-by":"crossref","first-page":"14392","DOI":"10.1038\/ncomms14392","article-title":"IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes","volume":"8","author":"Almine","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.heliyon.2019.e02643_bib19","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1074\/jbc.M410542200","article-title":"IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor\/JAK\/STAT pathway in medullary thyroid carcinoma cells","volume":"280","author":"Kim","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"issue":"598608","key":"10.1016\/j.heliyon.2019.e02643_bib20","first-page":"1992","article-title":"Interferon-inducible IFI16 protein in human cancers and autoimmune diseases","volume":"13","author":"Choubey","year":"2008","journal-title":"Front. Biosci."},{"issue":"11","key":"10.1016\/j.heliyon.2019.e02643_bib21","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1158\/1541-7786.MCR-08-0208","article-title":"Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53","volume":"6","author":"Song","year":"2008","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bcmd.2003.10.002","article-title":"The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation","volume":"32","author":"Asefa","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jcb.22386","article-title":"Inducible activation of IFI 16 results in suppression of telomerase activity, growth suppression and induction of cellular senescence","volume":"109","author":"Clarke","year":"2010","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008569","article-title":"Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene","volume":"5","author":"Song","year":"2010","journal-title":"PLoS One"},{"issue":"42","key":"10.1016\/j.heliyon.2019.e02643_bib25","doi-asserted-by":"crossref","first-page":"40899","DOI":"10.1074\/jbc.M308012200","article-title":"IFI16 as a negative regulator in the regulation of p53 and p21Waf1","volume":"278","author":"Kwak","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heliyon.2019.e02643_bib26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2741\/2673","article-title":"Role of IFI16 in DNA damage and checkpoint","volume":"13","author":"Ouchi","year":"2008","journal-title":"Front. Biosci."},{"issue":"4","key":"10.1016\/j.heliyon.2019.e02643_bib27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/jlb.64.4.546","article-title":"The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations","volume":"64","author":"Dawson","year":"1998","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.heliyon.2019.e02643_bib28","first-page":"2015","article-title":"IFI16 expression is related to selected transcription factors during B-cell differentiation","author":"Piccaluga","year":"2015","journal-title":"J.\u00a0Immunol. Res."},{"issue":"5","key":"10.1016\/j.heliyon.2019.e02643_bib29","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1182\/blood-2009-06-227017","article-title":"Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells","volume":"115","author":"Basso","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.heliyon.2019.e02643_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/apm.12692","article-title":"IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia","volume":"125","author":"Piccaluga","year":"2017","journal-title":"Apmis"},{"issue":"7","key":"10.1016\/j.heliyon.2019.e02643_bib31","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3324\/haematol.12754","article-title":"Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas","volume":"93","author":"Piccaluga","year":"2008","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13000-014-0221-9","article-title":"Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue\u2013a review","volume":"9","author":"Fedchenko","year":"2014","journal-title":"Diagn. Pathol."},{"issue":"22","key":"10.1016\/j.heliyon.2019.e02643_bib33","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1158\/0008-5472.CAN-07-1708","article-title":"Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation","volume":"67","author":"Piccaluga","year":"2007","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.heliyon.2019.e02643_bib34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1172\/JCI26833","article-title":"Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets","volume":"117","author":"Piccaluga","year":"2007","journal-title":"J.\u00a0Clin. Investig."},{"issue":"13","key":"10.1016\/j.heliyon.2019.e02643_bib35","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1182\/blood-2010-08-301556","article-title":"Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes","volume":"117","author":"Piccaluga","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.heliyon.2019.e02643_bib36","series-title":"Molecular Profiling Improves Classification and Prognostication of Nodal Peripheral T-Cell Lymphomas: Results of a Phase III Diagnostic Accuracy Study","author":"Piccaluga","year":"2013"},{"key":"10.1016\/j.heliyon.2019.e02643_bib37","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3389\/fmicb.2014.00728","article-title":"Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus","volume":"5","author":"Navari","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.heliyon.2019.e02643_bib38","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fmicb.2015.00556","article-title":"The presence of Epstein-Barr virus significantly impacts the transcriptional profile in immunodeficiency-associated Burkitt lymphoma","volume":"6","author":"Navari","year":"2015","journal-title":"Front. Microbiol."},{"issue":"43","key":"10.1016\/j.heliyon.2019.e02643_bib39","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"20","key":"10.1016\/j.heliyon.2019.e02643_bib40","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1158\/0008-5472.CAN-12-1615","article-title":"Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features","volume":"72","author":"Navarro","year":"2012","journal-title":"Cancer Res."},{"issue":"6769","key":"10.1016\/j.heliyon.2019.e02643_bib41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib42","first-page":"29","article-title":"Possible role of CD22, CD79b and CD20 expression in distinguishing small lymphocytic lymphoma from chronic lymphocytic leukemia","volume":"18","author":"Jovanovic","year":"2014","journal-title":"Contemp. Oncol."},{"key":"10.1016\/j.heliyon.2019.e02643_bib43","article-title":"Identification of candidate tumor suppressor genes silenced epigenetically in mantle cell lymphoma","author":"Kawamata","year":"2005","journal-title":"Am Soc Hematol."},{"issue":"7","key":"10.1016\/j.heliyon.2019.e02643_bib44","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.acthis.2010.11.001","article-title":"Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma","volume":"113","author":"Henson","year":"2011","journal-title":"Acta Histochem."},{"issue":"2","key":"10.1016\/j.heliyon.2019.e02643_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.leukres.2007.06.002","article-title":"CD45 expression in low-grade B-cell non-Hodgkin's lymphomas","volume":"32","author":"Carulli","year":"2008","journal-title":"Leuk. Res."},{"issue":"10","key":"10.1016\/j.heliyon.2019.e02643_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205537","article-title":"NKL homeobox gene activities in B-cell development and lymphomas","volume":"13","author":"Nagel","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.heliyon.2019.e02643_bib47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1476-4598-5-18","article-title":"Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells","volume":"5","author":"Liu","year":"2006","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.heliyon.2019.e02643_bib48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1535-6108(03)00028-X","article-title":"The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma","volume":"3","author":"Rosenwald","year":"2003","journal-title":"Cancer Cell"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019363030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844019363030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T08:56:41Z","timestamp":1738486601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844019363030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S2405844019363030"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02643","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e02643"}}