{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:27:40Z","timestamp":1790724460122,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFC1003502"],"award-info":[{"award-number":["2018YFC1003502"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["Z20192008"],"award-info":[{"award-number":["Z20192008"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.heliyon.2020.e04793","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T08:14:56Z","timestamp":1598429696000},"page":"e04793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["A drug screening toolkit based on the \u20131 ribosomal frameshifting of SARS-CoV-2"],"prefix":"10.1016","volume":"6","author":[{"given":"Yanqiong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-0066","authenticated-orcid":false,"given":"Lili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-5704","authenticated-orcid":false,"given":"Xiufeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.heliyon.2020.e04793_bib1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2020.04.011","article-title":"The architecture of SARS-CoV-2 transcriptome","volume":"181","author":"Kim","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.heliyon.2020.e04793_bib2","series-title":"Structural and Functional Conservation of the Programmed -1 Ribosomal Frameshift Signal of SARS-CoV-2","author":"Kelly","year":"2020"},{"key":"10.1016\/j.heliyon.2020.e04793_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.virol.2004.11.038","article-title":"Programmed ribosomal frameshifting in decoding the SARS-CoV genome","volume":"332","author":"Baranov","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.heliyon.2020.e04793_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/wrna.1126","article-title":"Mechanisms and implications of programmed translational frameshifting","volume":"3","author":"Dinman","year":"2012","journal-title":"Wiley interdisciplinary reviews. RNA"},{"key":"10.1016\/j.heliyon.2020.e04793_bib5","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1093\/nar\/gki731","article-title":"An atypical RNA pseudoknot stimulator and an upstream attenuation signal for \u22121 ribosomal frameshifting of SARS coronavirus","volume":"33","author":"Su","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2020.e04793_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/187152609787847659","article-title":"Drug targets in severe acute respiratory syndrome (SARS) virus and other coronavirus infections","volume":"9","author":"Tommy","year":"2009","journal-title":"Infect. Disord. - Drug Targets"},{"key":"10.1016\/j.heliyon.2020.e04793_bib7","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/JVI.02480-09","article-title":"Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins","volume":"84","author":"Plant","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.heliyon.2020.e04793_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2011.04.009","article-title":"Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication","volume":"91","author":"Ahn","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.heliyon.2020.e04793_bib9","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.1021\/ja1098325","article-title":"Identification of RNA pseudoknot-binding ligand that inhibits the \u22121 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening","volume":"133","author":"Park","year":"2011","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.heliyon.2020.e04793_bib10","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1073\/pnas.2000467117","article-title":"Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment","volume":"117","author":"Gurdon","year":"2020","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.heliyon.2020.e04793_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-1119(91)90270-L","article-title":"Modulation of firefly luciferase stability and impact on studies of gene regulation","volume":"103","author":"Thompson","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.heliyon.2020.e04793_bib12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/nar\/gkh256","article-title":"A\u00a0programmed \u20131 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element","volume":"32","author":"Plant","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heliyon.2020.e04793_bib13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A\u00a0novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heliyon.2020.e04793_bib14","series-title":"Drug Repurposing Screens Reveal FDA Approved Drugs Active against SARS-Cov-2","author":"Dittmar","year":"2020"},{"key":"10.1016\/j.heliyon.2020.e04793_bib15","series-title":"A\u00a0Large-Scale Drug Repositioning Survey for SARS-CoV-2 Antivirals","author":"Riva","year":"2020"},{"key":"10.1016\/j.heliyon.2020.e04793_bib16","doi-asserted-by":"crossref","first-page":"104960","DOI":"10.1016\/j.phrs.2020.104960","article-title":"Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system","volume":"159","author":"Yuan","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.heliyon.2020.e04793_bib17","series-title":"Antiviral Drug Screen of Kinase Inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication","author":"Garcia","year":"2020"},{"key":"10.1016\/j.heliyon.2020.e04793_bib18","series-title":"Broad Anti-coronaviral Activity of FDA Approved Drugs against SARS-CoV-2 in Vitro and SARS-CoV in Vivo","author":"Weston","year":"2020"},{"key":"10.1016\/j.heliyon.2020.e04793_bib19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.abc6197","article-title":"Reducing transmission of SARS-CoV-2","volume":"368","author":"Prather","year":"2020","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.heliyon.2020.e04793_bib20","doi-asserted-by":"crossref","first-page":"11133","DOI":"10.1073\/pnas.162223099","article-title":"A\u00a0\u22121 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA","volume":"99","author":"Barry","year":"2002","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.heliyon.2020.e04793_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cell.2018.12.030","article-title":"Regulation of HIV-1 gag-pol expression by shiftless, an inhibitor of programmed -1 ribosomal frameshifting","volume":"176","author":"Wang","year":"2019","journal-title":"Cell"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844020316364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844020316364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:11:27Z","timestamp":1754601087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844020316364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S2405844020316364"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2020.e04793","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A drug screening toolkit based on the \u20131 ribosomal frameshifting of SARS-CoV-2","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2020.e04793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e04793"}}