{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:34:22Z","timestamp":1792784062580,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o Herm\u00ednio Ometto\/FHO","id":[{"id":"https:\/\/ror.org\/04z7f4v54","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.heliyon.2020.e05406","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T02:20:54Z","timestamp":1604283654000},"page":"e05406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regulation of connexins genes expression contributes to reestablishes tissue homeostasis in a renovascular hypertension model"],"prefix":"10.1016","volume":"6","author":[{"given":"Ana Laura Tavares","family":"Enes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vinicius","family":"Gr\u00e9gio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Goulart","family":"Clec\u00eancio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Esm\u00e9ria Corezola","family":"do Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Andr\u00e9a","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2020.e05406_bib1","doi-asserted-by":"crossref","first-page":"406960","DOI":"10.1155\/2014\/406960","article-title":"Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension","volume":"2014","author":"Dinh","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.heliyon.2020.e05406_bib2","doi-asserted-by":"crossref","first-page":"236239","DOI":"10.4061\/2011\/236239","article-title":"Common secondary causes of resistant hypertension and rational for treatment","volume":"2011","author":"Faselis","year":"2011","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.heliyon.2020.e05406_bib3","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1161\/CIRCULATIONAHA.104.492348","article-title":"Renovascular hypertension and ischemic nephropathy","volume":"112","author":"Garovic","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.heliyon.2020.e05406_bib4","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1172\/JCI23360","article-title":"Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide","volume":"115","author":"Sabrane","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.heliyon.2020.e05406_bib5","first-page":"1","article-title":"Regulation of renin release by local and systemic factors","volume":"161","author":"Schweda","year":"2011","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib6","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00018-010-0551-z","article-title":"Structure of the gap junction channel and its implications for its biological functions","volume":"68","author":"Maeda","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.heliyon.2020.e05406_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbamem.2004.12.001","article-title":"Connexins and their environment: effects of lipids composition on ion channels","volume":"1711","author":"Cascio","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heliyon.2020.e05406_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1741-7007-7-52","article-title":"Connexin channels and phospholipids: association and modulation","volume":"7","author":"Locke","year":"2009","journal-title":"BMC Biol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jnutbio.2016.09.011","article-title":"Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad and cholesterol metabolism genes","volume":"39","author":"Santolim","year":"2017","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.heliyon.2020.e05406_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/ars.2008.2115","article-title":"Connexins in vascular physiology and pathology","volume":"11","author":"C Brisset","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.heliyon.2020.e05406_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/BC.2006.002","article-title":"Endothelial mediators and communication through vascular gap junctions","volume":"387","author":"de Wit C","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.heliyon.2020.e05406_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ars.2008.2117","article-title":"Gap junctions in the control of vascular function","volume":"11","author":"Figueroa","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.heliyon.2020.e05406_bib13","doi-asserted-by":"crossref","first-page":"R1143","DOI":"10.1152\/ajpregu.00808.2009","article-title":"Connexins and the kidney","volume":"298","author":"Hanner","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1523-1755.2005.00509.x","article-title":"Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes","volume":"68","author":"Zhang","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.heliyon.2020.e05406_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1053\/jhep.2002.35274","article-title":"Expression and regulation of gap junctions in rat cholangiocytes","volume":"36","author":"Bode","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.heliyon.2020.e05406_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00441-006-0165-9","article-title":"Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development","volume":"324","author":"Shiojiri","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heliyon.2020.e05406_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.59.3.347","article-title":"Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischaemia","volume":"59","author":"Goldblatt","year":"1934","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.heliyon.2020.e05406_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13105-015-0394-z","article-title":"Investigation of changes in apelin receptor mRNA and protein expression in the myocardium and aorta of rats with two-kidney, one-clip (2K1C) Goldblatt hypertension","volume":"71","author":"Najafipour","year":"2015","journal-title":"J.\u00a0Physiol. Biochem."},{"key":"10.1016\/j.heliyon.2020.e05406_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/B:HREV.0000011392.03037.7e","article-title":"The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling","volume":"9","author":"Janicki","year":"2004","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.heliyon.2020.e05406_bib20","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCULATIONAHA.113.002671","article-title":"High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy","volume":"128","author":"Mora","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.heliyon.2020.e05406_bib21","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1124\/jpet.103.055178","article-title":"Inhibition of adrenal cortical steroid formation by procaine is mediated by reduction of the cAMP-induced 3-hydroxy-3-methylglutaryl-coenzyme A reductase messenger ribonucleic acid levels","volume":"307","author":"Xu","year":"2013","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.heliyon.2020.e05406_bib22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.STR.28.3.557","article-title":"Serum creatinine concentration and risk of cardiovascular disease: a possible marker for increased risk of stroke","volume":"28","author":"Wannamethee","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.heliyon.2020.e05406_bib23","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ki.2011.417","article-title":"Renal outcomes in hypertensive Black patients at high cardiovascular risk","volume":"81","author":"Weir","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.heliyon.2020.e05406_bib24","first-page":"170","article-title":"Unraveling the Mystery of Goldblatt hypertension","volume":"13","author":"Navar","year":"1998","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.heliyon.2020.e05406_bib25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/HYPERTENSIONAHA.115.06040","article-title":"Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice","volume":"66","author":"Yiannkouris","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.heliyon.2020.e05406_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/ATVBAHA.115.306740","article-title":"Angiotensinogen exerts effects independent of angiotensin II","volume":"36","author":"Lu","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00109-007-0166-5","article-title":"Effect of the angiotensinogen genotype on experimental hypertension in mice","volume":"85","author":"Handtrack","year":"2007","journal-title":"J.\u00a0Mol. Med. (Berl)."},{"key":"10.1016\/j.heliyon.2020.e05406_bib28","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2337\/dc08-0371","article-title":"Preventing left ventricular hypertrophy by ACE inhibition in hypertensive patients with type 2 diabetes: a prespecified analysis of the Bergamo Nephrologic Diabetes Complications Trial (BENEDICT)","volume":"31","author":"Ruggenenti","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.heliyon.2020.e05406_bib29","doi-asserted-by":"crossref","first-page":"17985","DOI":"10.1073\/pnas.0605545103","article-title":"Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney","volume":"103","author":"Crowley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.heliyon.2020.e05406_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/2230-8210.107869","article-title":"Physiology and clinical significance of natriuretic hormones","volume":"17","author":"Chopra","year":"2013","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.heliyon.2020.e05406_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/01.HYP.0000042664.75193.1B","article-title":"TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus","volume":"41","author":"Tremblay","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.heliyon.2020.e05406_bib32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.peptides.2004.09.024","article-title":"Biology of natriuretic peptides and their receptors","volume":"26","author":"Pandey","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.heliyon.2020.e05406_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmet.2011.03.001","article-title":"AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure","volume":"13","author":"Gurley","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib34","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.HYP.0000051890.68573.94","article-title":"Angiotensin II-mediated negative regulation of Npr1 promoter activity and gene transcription","volume":"41","author":"Garg","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.heliyon.2020.e05406_bib35","first-page":"405","article-title":"Connexin and pannexin (hemi)channels in the liver","volume":"4","author":"Maes","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1440-1681.12701","article-title":"Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis","volume":"44","author":"Tiburcio","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.foodchem.2011.03.050","article-title":"Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats' kidney and liver","volume":"128","author":"Jaffri","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.heliyon.2020.e05406_bib38","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jhep.2013.01.023","article-title":"Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure","volume":"58","author":"Balasubramaniyan","year":"2013","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib39","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/CIRCRESAHA.107.168997","article-title":"Connexin 40 imparts conduction heterogeneity to atrial tissue","volume":"103","author":"Leaf","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.heliyon.2020.e05406_bib40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-55330-6_12","article-title":"Connexin 43 and Mitochondria in cardiovascular Health and disease","volume":"982","author":"Boengler","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib41","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.bbamem.2011.05.023","article-title":"Renal connexins and blood pressure","volume":"1818","author":"Kurtz","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heliyon.2020.e05406_bib42","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.lfs.2005.09.036","article-title":"Connexin 32 down-regulates the fibrinolytic factors in metastatic renal cell carcinoma cells","volume":"78","author":"Hagiwara","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.heliyon.2020.e05406_bib43","doi-asserted-by":"crossref","first-page":"F24","DOI":"10.1152\/ajprenal.00255.2010","article-title":"Alteration of connexin expression is an early signal for chronic kidney disease","volume":"301","author":"Toubas","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.heliyon.2020.e05406_bib44","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/01.RES.0000258856.19922.45","article-title":"Connexin40 is essential for the pressure control of renin synthesis and secretion","volume":"100","author":"Wagner","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.heliyon.2020.e05406_bib45","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00424-014-1615-y","article-title":"Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion","volume":"467","author":"Machura","year":"2015","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.heliyon.2020.e05406_bib46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1172\/JCI23327","article-title":"Connexin43-dependent mechanism modulates renin secretion and hypertension","volume":"116","author":"Haefliger","year":"2006","journal-title":"J.\u00a0Clin. Invest."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844020322490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844020322490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:56:58Z","timestamp":1790351818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844020322490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2405844020322490"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2020.e05406","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of connexins genes expression contributes to reestablishes tissue homeostasis in a renovascular hypertension model","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2020.e05406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e05406"}}