{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:12:22Z","timestamp":1771913542566,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003200","name":"Kementerian Sains, Teknologi dan Inovasi","doi-asserted-by":"publisher","award":["7204"],"award-info":[{"award-number":["7204"]}],"id":[{"id":"10.13039\/501100003200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003200","name":"Kementerian Sains, Teknologi dan Inovasi","doi-asserted-by":"publisher","award":["FP44842-233-2015"],"award-info":[{"award-number":["FP44842-233-2015"]}],"id":[{"id":"10.13039\/501100003200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003200","name":"Kementerian Sains, Teknologi dan Inovasi","doi-asserted-by":"publisher","award":["ID 3964"],"award-info":[{"award-number":["ID 3964"]}],"id":[{"id":"10.13039\/501100003200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009543","name":"Pontificia Universidad Javeriana","doi-asserted-by":"publisher","award":["6699"],"award-info":[{"award-number":["6699"]}],"id":[{"id":"10.13039\/501100009543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022282","name":"Universidad de Ciencias Aplicadas y Ambientales","doi-asserted-by":"publisher","award":["15402038"],"award-info":[{"award-number":["15402038"]}],"id":[{"id":"10.13039\/501100022282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["120356933205"],"award-info":[{"award-number":["120356933205"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["120356933427"],"award-info":[{"award-number":["120356933427"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["ID 5170"],"award-info":[{"award-number":["ID 5170"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["ID 5174"],"award-info":[{"award-number":["ID 5174"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.heliyon.2022.e09031","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T12:08:10Z","timestamp":1646136490000},"page":"e09031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iduronate-2-sulfatase interactome: validation by yeast two-hybrid assay"],"prefix":"10.1016","volume":"8","author":[{"given":"Eliana","family":"Benincore-Fl\u00f3rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-1018","authenticated-orcid":false,"given":"Jorge","family":"El-Azaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Alejandra","family":"Solarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-5298","authenticated-orcid":false,"given":"Luis H.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Javier","family":"Alm\u00e9ciga-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Cardona-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2022.e09031_bib1","series-title":"Mucopolysaccharidoses Update (2 Volume Set)","first-page":"165","article-title":"Mucopolysaccharidosis type II: clinical features, biochemistry, diagnosis, genetics and treatment","author":"Tomatsu","year":"2018"},{"issue":"4","key":"10.1016\/j.heliyon.2022.e09031_bib2","article-title":"Mucopolysaccharidosis type II: one hundred years of research, diagnosis, and treatment","volume":"21","author":"D'Avanzo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ymgme.2014.08.009","article-title":"Safety and efficacy of enzyme replacement therapy with idursulfase beta in children aged younger than 6 years with Hunter syndrome","volume":"114","author":"Sohn","year":"2015","journal-title":"Mol. Genet. Metabol."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/GIM.0b013e3181fea459","article-title":"Long-term, open-labeled extension study of idursulfase in the treatment of Hunter syndrome","volume":"13","author":"Muenzer","year":"2011","journal-title":"Genet. Med. : Off. J. Am. Coll. Med. Genet."},{"key":"10.1016\/j.heliyon.2022.e09031_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1750-1172-6-72","article-title":"Mucopolysaccharidosis type II: European recommendations for the diagnosis and multidisciplinary management of a rare disease","volume":"6","author":"Scarpa","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"issue":"23","key":"10.1016\/j.heliyon.2022.e09031_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235829","article-title":"Autophagy in the central nervous system and effects of chloroquine in mucopolysaccharidosis type II mice","volume":"20","author":"Maeda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2022.e09031_bib7","doi-asserted-by":"crossref","first-page":"e906","DOI":"10.1038\/cddis.2013.430","article-title":"Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved","volume":"4","author":"Fusar","year":"2013","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.heliyon.2022.e09031_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708730","article-title":"Brain-targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms","volume":"10","author":"Gleitz","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.heliyon.2022.e09031_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051072","article-title":"Brain RNA-seq profiling of the mucopolysaccharidosis type II mouse model","volume":"18","author":"Salvalaio","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.heliyon.2022.e09031_bib10","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1542\/peds.2006-2156","article-title":"Enzyme replacement therapy in patients who have mucopolysaccharidosis I and are younger than 5 years: results of a multinational study of recombinant human alpha-L-iduronidase (laronidase)","volume":"120","author":"Wraith","year":"2007","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/GIM.0b013e318206786f","article-title":"Idursulfase treatment of Hunter syndrome in children younger than 6 years: results from the Hunter Outcome Survey","volume":"13","author":"Muenzer","year":"2011","journal-title":"Genet. Med."},{"key":"10.1016\/j.heliyon.2022.e09031_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13023-015-0356-0","article-title":"Effect of systemic high dose enzyme replacement therapy on the improvement of CNS defects in a mouse model of mucopolysaccharidosis type II","volume":"10","author":"Cho","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"issue":"11","key":"10.1016\/j.heliyon.2022.e09031_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115490","article-title":"Gene therapy for mucopolysaccharidosis type II-A review of the current possibilities","volume":"22","author":"Zapolnik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ymgme.2017.12.428","article-title":"Chaperone effect of sulfated disaccharide from heparin on mutant iduronate-2-sulfatase in mucopolysaccharidosis type II","volume":"123","author":"Hoshina","year":"2018","journal-title":"Mol. Genet. Metabol."},{"issue":"8","key":"10.1016\/j.heliyon.2022.e09031_bib15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41419-018-0871-8","article-title":"Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II","volume":"9","author":"Osaki","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell's functional organization","volume":"5","author":"Barabasi","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.heliyon.2022.e09031_bib17","doi-asserted-by":"crossref","first-page":"e01667","DOI":"10.1016\/j.heliyon.2019.e01667","article-title":"Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain","volume":"5","author":"Cardona","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.heliyon.2022.e09031_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/1176934318775081","article-title":"Molecular evolution and functional divergence of the IgLON family","volume":"14","author":"Kubick","year":"2018","journal-title":"Evol. Bioinform."},{"issue":"4","key":"10.1016\/j.heliyon.2022.e09031_bib19","first-page":"665","article-title":"[Polyradiculoneuritis. Increase of the occurrence of the severe forms]","volume":"35","author":"Fierro","year":"1978","journal-title":"Bol. Med. Hosp. Infant. Mex."},{"issue":"6","key":"10.1016\/j.heliyon.2022.e09031_bib20","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.4049\/jimmunol.0803609","article-title":"Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss","volume":"184","author":"Wu","year":"2010","journal-title":"J.\u00a0Immunol."},{"issue":"20","key":"10.1016\/j.heliyon.2022.e09031_bib21","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1182\/blood-2013-10-535831","article-title":"STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a","volume":"123","author":"van Breevoort","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.heliyon.2022.e09031_bib22","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3389\/fnins.2018.01019","article-title":"Transcytosis to cross the blood brain barrier, new advancements and challenges","volume":"12","author":"Pulgar","year":"2018","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.heliyon.2022.e09031_bib23","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/pmic.200800612","article-title":"PPI spider: a tool for the interpretation of proteomics data in the context of protein-protein interaction networks","volume":"9","author":"Antonov","year":"2009","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.heliyon.2022.e09031_bib24","doi-asserted-by":"crossref","first-page":"e0150239","DOI":"10.1371\/journal.pone.0150239","article-title":"Identification of interactions in the NMD complex using proximity-dependent biotinylation (BioID)","volume":"11","author":"Schweingruber","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2022.e09031_bib25","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.heliyon.2022.e09031_bib26","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"14","key":"10.1016\/j.heliyon.2022.e09031_bib27","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/bioinformatics\/btt260","article-title":"InterEvScore: a novel coarse-grained interface scoring function using a multi-body statistical potential coupled to evolution","volume":"29","author":"Andreani","year":"2013","journal-title":"Bioinformatics"},{"issue":"19","key":"10.1016\/j.heliyon.2022.e09031_bib28","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1093\/bioinformatics\/btp447","article-title":"FRODOCK: a new approach for fast rotational protein-protein docking","volume":"25","author":"Garzon","year":"2009","journal-title":"Bioinformatics"},{"issue":"15","key":"10.1016\/j.heliyon.2022.e09031_bib29","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1093\/bioinformatics\/btw141","article-title":"FRODOCK 2.0: fast protein-protein docking server","volume":"32","author":"Ramirez-Aportela","year":"2016","journal-title":"Bioinformatics"},{"issue":"24","key":"10.1016\/j.heliyon.2022.e09031_bib30","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1093\/bioinformatics\/btt560","article-title":"Optimized atomic statistical potentials: assessment of protein interfaces and loops","volume":"29","author":"Dong","year":"2013","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.heliyon.2022.e09031_bib31","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbamcr.2008.12.001","article-title":"Lysosomal disorders: from storage to cellular damage","volume":"1793","author":"Ballabio","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ymgme.2015.08.001","article-title":"Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network","volume":"117","author":"Salazar","year":"2016","journal-title":"Mol. Genet. Metabol."},{"issue":"5","key":"10.1016\/j.heliyon.2022.e09031_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051072","article-title":"Brain RNA-seq profiling of the mucopolysaccharidosis type II mouse model","volume":"18","author":"Salvalaio","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2022.e09031_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-59745-170-3_19","article-title":"Reverse two-hybrid screening to analyze protein-protein interaction of HIV-1 viral and cellular proteins","volume":"485","author":"Das","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.heliyon.2022.e09031_bib35","doi-asserted-by":"crossref","first-page":"e50009","DOI":"10.1371\/journal.pone.0050009","article-title":"A\u00a0comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins","volume":"7","author":"Kuroda","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2022.e09031_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/bs.mcb.2015.03.012","article-title":"A\u00a0yeast two-hybrid approach for probing protein-protein interactions at the centrosome","volume":"129","author":"Galletta","year":"2015","journal-title":"Methods Cell Biol."},{"issue":"12","key":"10.1016\/j.heliyon.2022.e09031_bib37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/gm114","article-title":"Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases","volume":"1","author":"Nathan","year":"2009","journal-title":"Genome Med."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib38","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.221739","article-title":"Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases","volume":"132","author":"Marques","year":"2019","journal-title":"J.\u00a0Cell Sci."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2012.05.052","article-title":"Challenges in design and characterization of ligand-targeted drug delivery systems","volume":"164","author":"Muro","year":"2012","journal-title":"J.\u00a0Contr. Release"},{"issue":"6","key":"10.1016\/j.heliyon.2022.e09031_bib40","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1085\/jgp.201711944","article-title":"The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis","volume":"150","author":"MacDougall","year":"2018","journal-title":"J.\u00a0Gen. Physiol."},{"issue":"10","key":"10.1016\/j.heliyon.2022.e09031_bib41","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1073\/pnas.0712372105","article-title":"Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis","volume":"105","author":"Maximov","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.heliyon.2022.e09031_bib42","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.neuron.2016.12.010","article-title":"Synaptotagmin-1- and synaptotagmin-7-dependent fusion mechanisms target synaptic vesicles to kinetically distinct endocytic pathways","volume":"93","author":"Li","year":"2017","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.heliyon.2022.e09031_bib43","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0092-8674(94)90442-1","article-title":"Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling","volume":"78","author":"Zhang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.heliyon.2022.e09031_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-physiol-021113-170305","article-title":"Exocytosis and endocytosis: modes, functions, and coupling mechanisms","volume":"76","author":"Wu","year":"2014","journal-title":"Annu. Rev. Physiol."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nn.3013","article-title":"Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles","volume":"15","author":"Yao","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"47","key":"10.1016\/j.heliyon.2022.e09031_bib46","doi-asserted-by":"crossref","first-page":"16648","DOI":"10.1073\/pnas.0406968101","article-title":"Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I","volume":"101","author":"Nicholson-Tomishima","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 1","key":"10.1016\/j.heliyon.2022.e09031_bib47","first-page":"1","article-title":"Clathrin-dependent endocytosis","volume":"377","author":"Mousavi","year":"2004","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.heliyon.2022.e09031_bib48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10719-014-9523-0","article-title":"A\u00a0biochemical and physicochemical comparison of two recombinant enzymes used for enzyme replacement therapies of hunter syndrome","volume":"31","author":"Chung","year":"2014","journal-title":"Glycoconj. J."},{"issue":"1","key":"10.1016\/j.heliyon.2022.e09031_bib49","first-page":"77","article-title":"The uptake of enzymes into lysosomes: an overview","volume":"16","author":"Neufeld","year":"1980","journal-title":"Birth Defects Orig. Artic. Ser."},{"issue":"8","key":"10.1016\/j.heliyon.2022.e09031_bib50","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"41","key":"10.1016\/j.heliyon.2022.e09031_bib51","doi-asserted-by":"crossref","first-page":"15908","DOI":"10.1073\/pnas.0808360105","article-title":"Aptamer-based endocytosis of a lysosomal enzyme","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.heliyon.2022.e09031_bib52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/cbf.1730","article-title":"IgLONs form heterodimeric complexes on forebrain neurons","volume":"29","author":"McNamee","year":"2011","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.heliyon.2022.e09031_bib53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ebiom.2019.10.009","article-title":"LSAMP-AS1 binds to microRNA-183-5p to suppress the progression of prostate cancer by up-regulating the tumor suppressor DCN","volume":"50","author":"Hua","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.heliyon.2022.e09031_bib54","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00429-014-0732-x","article-title":"Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain","volume":"220","author":"Philips","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"7","key":"10.1016\/j.heliyon.2022.e09031_bib55","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0960-9822(93)90350-W","article-title":"SH2 and SH3 domains","volume":"3","author":"Pawson","year":"1993","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heliyon.2022.e09031_bib56","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fnins.2014.00392","article-title":"\"You Shall Not Pass\"-tight junctions of the blood brain barrier","volume":"8","author":"Bauer","year":"2014","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.heliyon.2022.e09031_bib57","doi-asserted-by":"crossref","first-page":"e1154641","DOI":"10.1080\/21688370.2016.1154641","article-title":"Junctional proteins of the blood-brain barrier: new insights into function and dysfunction","volume":"4","author":"Stamatovic","year":"2016","journal-title":"Tissue Barriers"},{"issue":"12","key":"10.1016\/j.heliyon.2022.e09031_bib58","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1002\/eji.201545632","article-title":"Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha4beta1-integrin","volume":"45","author":"Martin-Blondel","year":"2015","journal-title":"Eur. J. Immunol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240584402200319X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240584402200319X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:10:17Z","timestamp":1762513817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240584402200319X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S240584402200319X"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09031","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iduronate-2-sulfatase interactome: validation by yeast two-hybrid assay","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e09031"}}