{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:37:40Z","timestamp":1769521060547,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012964","name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.heliyon.2022.e09986","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T23:30:51Z","timestamp":1658187051000},"page":"e09986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Meta-analysis of HLA-G 14bp insertion\/deletion polymorphism and soluble HLA-G revealed an association with digestive cancers initiation and prognosis"],"prefix":"10.1016","volume":"8","author":[{"given":"Sabrine","family":"Dhouioui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Boujelbene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-554X","authenticated-orcid":false,"given":"Hadda-imene","family":"Ouzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalthoum","family":"Tizaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-4957","authenticated-orcid":false,"given":"In\u00e8s","family":"Zidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2022.e09986_bib1","first-page":"5933","article-title":"High expression of estrogen-related receptor alpha is significantly associated with poor prognosis in patients with colorectal cancer","volume":"15","author":"Liang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.heliyon.2022.e09986_bib2","first-page":"1943","article-title":"Immunoglobulinlike transcript 4 and human leukocyte antigenG interaction promotes the progression of human colorectal cancer","volume":"54","author":"Cai","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib3","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.3389\/fimmu.2020.01685","article-title":"HLA-G Neo-expression on tumors","volume":"11","author":"Loustau","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.ai.2015.04.001","article-title":"HLA-G: an immune checkpoint molecule","volume":"127","author":"Carosella","year":"2015","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2011.07.019","article-title":"Human leukocyte antigen-G in cancer: are they clinically relevant?","volume":"311","author":"Yan","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.heliyon.2022.e09986_bib6","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1245\/s10434-007-9464-y","article-title":"Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma","volume":"14","author":"Yie","year":"2007","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/tan.12427","article-title":"New insights into HLA-G mediated tolerance","volume":"84","author":"Amodio","year":"2014","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.heliyon.2022.e09986_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00018-010-0583-4","article-title":"Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?","volume":"68","author":"Amiot","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.heliyon.2022.e09986_bib9","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3389\/fimmu.2018.02164","article-title":"Heterogeneity of HLA-G expression in cancers: facing the challenges","volume":"9","author":"Lin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib10","article-title":"Some basic aspects of HLA-G biology","volume":"2014","author":"Alegre","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.heliyon.2022.e09986_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1399-0039.2008.01107.x","article-title":"The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma","volume":"72","author":"Chen","year":"2008","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.heliyon.2022.e09986_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.humimm.2003.08.347","article-title":"The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability","volume":"64","author":"Rousseau","year":"2003","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1086\/521200","article-title":"Allele-specific targeting of microRNAs to HLA-G and risk of asthma","volume":"81","author":"Tan","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.heliyon.2022.e09986_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.heliyon.2022.e09986_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib16","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2019"},{"key":"10.1016\/j.heliyon.2022.e09986_bib17","series-title":"Introduction to Meta-Analysis","author":"Michael Borenstein","year":"2009"},{"key":"10.1016\/j.heliyon.2022.e09986_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jrsm.6","article-title":"Graphical displays for meta-analysis: an overview with suggestions for practice","volume":"1","author":"Anzures-Cabrera","year":"2010","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.heliyon.2022.e09986_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.heliyon.2022.e09986_bib20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.heliyon.2022.e09986_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.heliyon.2022.e09986_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","article-title":"Meta-analysis: principles and procedures","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.heliyon.2022.e09986_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.humimm.2021.10.003","article-title":"Association of HLA-G 3\u2032UTR polymorphisms and haplotypes with colorectal cancer susceptibility and prognosis","volume":"83","author":"Dhouioui","year":"2022","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib24","first-page":"12","article-title":"HLA-G 3\u2019UTR polymorphisms are linked to susceptibility and survival in Spanish gastric adenocarcinoma patients","author":"Vaquero-Yuste","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib25","first-page":"gmr18324","article-title":"Relationship of HLA-G expression and its 14-bp insertion\/deletion polymorphism with susceptibility to colorectal cancer","volume":"18","author":"Abu Hassan","year":"2019","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.heliyon.2022.e09986_bib26","first-page":"255","article-title":"Association of HLA-G gene polymorphism with hepatocellular carcinoma in Egyptian population","volume":"32","author":"El Bassiouny","year":"2019","journal-title":"Menoufia Med. J."},{"key":"10.1016\/j.heliyon.2022.e09986_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/iji.12243","article-title":"Association of the HLA-G 3'UTR polymorphisms with colorectal cancer in Italy: a first insight","volume":"43","author":"Garziera","year":"2016","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.heliyon.2022.e09986_bib28","first-page":"796","article-title":"Association between HLA-G 14-bp insertion\/deletion polymorphism and hepatocellular carcinoma in Korean patients with chronic hepatitis B viral infection","volume":"60","author":"Kim","year":"2013","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.heliyon.2022.e09986_bib29","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/tan.12097","article-title":"The 14bp-deletion allele in the HLA-G gene confers susceptibility to the development of hepatocellular carcinoma in the Brazilian population","volume":"81","author":"Teixeira","year":"2013","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.heliyon.2022.e09986_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/1354750X.2011.633242","article-title":"Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang","volume":"17","author":"Chen","year":"2012","journal-title":"Biomarkers"},{"key":"10.1016\/j.heliyon.2022.e09986_bib31","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1089\/dna.2011.1238","article-title":"Association of HLA-G 3' UTR 14-bp insertion\/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population","volume":"30","author":"Jiang","year":"2011","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib32","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1007\/s12094-019-02244-2","article-title":"HLA-G as a new tumor biomarker: detection of soluble isoforms of HLA-G in the serum and saliva of patients with colorectal cancer","volume":"22","author":"Lazaro-Sanchez","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib33","first-page":"2731","article-title":"HLA-G expression in tumor tissues and soluble HLA-G plasma levels in patients with gastrointestinal cancer","volume":"19","author":"Farjadian","year":"2018","journal-title":"Asian Pac. J. Cancer Prev. APJCP : Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.heliyon.2022.e09986_bib34","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/ijc.30667","article-title":"Soluble HLA-G is a differential prognostic marker in sequential colorectal cancer disease stages","volume":"140","author":"Kirana","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heliyon.2022.e09986_bib35","article-title":"Importance of the plasma soluble HLA-G levels for prognostic stratification with traditional prognosticators in colorectal cancer","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.heliyon.2022.e09986_bib36","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317726840","article-title":"Evaluation of ascitic soluble human leukocyte antigen-G for distinguishing malignant ascites from benign ascites","volume":"39","author":"Sun","year":"2017","journal-title":"Tumor Biol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.humimm.2015.11.005","article-title":"Association of HLA-G\u221701:01:02:01\/G\u221701:04:01 polymorphism with gastric adenocarcinoma","volume":"77","author":"Khorrami","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.humimm.2016.01.009","article-title":"Diagnostic significance of soluble human leukocyte antigen-G for gastric cancer","volume":"77","author":"Pan","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib39","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.humimm.2016.01.003","article-title":"Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer","volume":"77","author":"Xu","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.imlet.2014.04.007","article-title":"Human leukocyte antigen G is associated with esophageal squamous cell carcinoma progression and poor prognosis","volume":"161","author":"Zheng","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.heliyon.2022.e09986_bib41","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/ijc.25807","article-title":"Human leukocyte antigen-G expression is associated with a poor prognosis in patients with esophageal squamous cell carcinoma","volume":"129","author":"Lin","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heliyon.2022.e09986_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1399-0039.2011.01814.x","article-title":"Soluble human leukocyte antigen-G expression in hepatitis B virus infection and hepatocellular carcinoma","volume":"79","author":"Park","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.heliyon.2022.e09986_bib43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ijc.25372","article-title":"Serum sHLA-G levels: a useful indicator in distinguishing colorectal cancer from benign colorectal diseases","volume":"128","author":"Zhu","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heliyon.2022.e09986_bib44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1499-3872(11)60025-8","article-title":"Expression of HLA-G in patients with hepatocellular carcinoma","volume":"10","author":"Wang","year":"2011","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.heliyon.2022.e09986_bib45","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1111\/j.1582-4934.2009.00917.x","article-title":"Aberrant human leucocyte antigen-G expression and its clinical relevance in hepatocellular carcinoma","volume":"14","author":"Lin","year":"2010","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.heliyon.2022.e09986_bib46","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15038263","article-title":"HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis","volume":"15","author":"Coelho","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.heliyon.2022.e09986_bib47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2893.2010.01286.x","article-title":"Liver HLA-G expression is associated with multiple clinical and histopathological forms of chronic hepatitis B virus infection","volume":"18","author":"Souto","year":"2011","journal-title":"J.\u00a0Viral Hepat."},{"key":"10.1016\/j.heliyon.2022.e09986_bib48","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.humimm.2011.02.008","article-title":"Elevation of plasma soluble human leukocyte antigen-G in patients with chronic hepatitis C virus infection","volume":"72","author":"Weng","year":"2011","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib49","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1053\/j.gastro.2018.11.066","article-title":"Large-scale genome-wide association study of East Asians identifies loci associated with risk for colorectal cancer","volume":"156","author":"Lu","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.heliyon.2022.e09986_bib50","article-title":"Prognostic and clinicopathological value of human leukocyte antigen G in gastrointestinal cancers: a meta-analysis","volume":"11","author":"Peng","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.heliyon.2022.e09986_bib51","article-title":"Predictive value of different proportion of lesion HLA-G expression in colorectal cancer","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.heliyon.2022.e09986_bib52","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1349-7006.2011.01951.x","article-title":"Human leukocyte antigen-G is closely associated with tumor immune escape in gastric cancer by increasing local regulatory T cells","volume":"102","author":"Du","year":"2011","journal-title":"Cancer Sci."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844022012749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844022012749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T22:16:43Z","timestamp":1755555403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844022012749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2405844022012749"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09986","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of HLA-G 14bp insertion\/deletion polymorphism and soluble HLA-G revealed an association with digestive cancers initiation and prognosis","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e09986"}}