{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:18:26Z","timestamp":1783117106479,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.heliyon.2023.e18907","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T14:51:37Z","timestamp":1691247097000},"page":"e18907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of immunomodulatory therapy in a human brucellosis patient with pancytopenia: A case report"],"prefix":"10.1016","volume":"9","author":[{"given":"Liankui","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-279X","authenticated-orcid":false,"given":"Jingbo","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.heliyon.2023.e18907_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s40249-020-00715-1","article-title":"Human brucellosis: recent advances and future challenges","volume":"9","author":"O\u2019Callaghan","year":"2020","journal-title":"Infect. Dis. Poverty"},{"issue":"12","key":"10.1016\/j.heliyon.2023.e18907_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1473-3099(07)70286-4","article-title":"Human brucellosis","volume":"7","author":"Franco","year":"2007","journal-title":"Lancet Infect. Dis."},{"issue":"21","key":"10.1016\/j.heliyon.2023.e18907_bib3","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3390\/ijerph16214289","article-title":"Prediction of human brucellosis in China based on temperature and NDVI","volume":"16","author":"Zhao","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.heliyon.2023.e18907_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2147\/IDR.S340866","article-title":"Seroprevalence and associated risk factors of ovine brucellosis in South omo zone, southern Ethiopia","volume":"15","author":"Sorsa","year":"2022","journal-title":"Infect. Drug Resist."},{"issue":"4","key":"10.1016\/j.heliyon.2023.e18907_bib5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ajh.21098","article-title":"A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis","volume":"83","author":"Sari","year":"2008","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.heliyon.2023.e18907_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.5533","article-title":"Myelodysplastic syndrome in a case of new\u2010onset pancytopenia","volume":"10","author":"Lancaster","year":"2022","journal-title":"Clin. Case Rep."},{"key":"10.1016\/j.heliyon.2023.e18907_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2020.e01037","article-title":"Pancytopenia revealing acute brucellosis","volume":"23","author":"Ben Lahlou","year":"2021","journal-title":"IDCases"},{"issue":"9","key":"10.1016\/j.heliyon.2023.e18907_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2169\/internalmedicine.47.0834","article-title":"The first documented case of brucellosis manifested with pancytopenia and capillary leak syndrome","volume":"47","author":"Erkurt","year":"2008","journal-title":"Intern. Med."},{"key":"10.1016\/j.heliyon.2023.e18907_bib9","series-title":"Method for Detecting Brucella Infection and Application Thereof (US-11505834-B2), United States Patent and Trademark Office","author":"Zhai","year":"2022"},{"issue":"5","key":"10.1016\/j.heliyon.2023.e18907_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/23744235.2019.1568545","article-title":"A review of the immunopathogenesis of Brucellosis","volume":"51","author":"Amjadi","year":"2019","journal-title":"Inf. Dis."},{"key":"10.1016\/j.heliyon.2023.e18907_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/21505594.2017.1386831","article-title":"Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo","volume":"9","author":"Zhao","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.heliyon.2023.e18907_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mib.2012.11.005","article-title":"Brucella T4SS: the VIP pass inside host cells","volume":"16","author":"Lacerda","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"issue":"7","key":"10.1016\/j.heliyon.2023.e18907_bib13","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.3390\/ijms22073673","article-title":"The mechanism of facultative intracellular parasitism of Brucella","volume":"22","author":"Jiao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.heliyon.2023.e18907_bib14","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.ajpath.2015.03.003","article-title":"Pathogenesis and immunobiology of brucellosis","volume":"185","author":"de Figueiredo","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e18907_bib15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ijantimicag.2004.05.003","article-title":"Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen","volume":"24","author":"Pappas","year":"2004","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"12","key":"10.1016\/j.heliyon.2023.e18907_bib16","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1371\/journal.pmed.0040317","article-title":"Perspectives for the treatment of brucellosis in the 21st century: the ioannina recommendations","volume":"4","author":"Ariza","year":"2007","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.heliyon.2023.e18907_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5414\/CNP73309","article-title":"Brucellosis in dialysis patients. Does it exist?","volume":"73","author":"Kantartzi","year":"2010","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.heliyon.2023.e18907_bib18","article-title":"Acute brucellosis presenting as an autoimmune hemolytic anemia","author":"Meena","year":"2018","journal-title":"Case Rep. Infect. Dis. 2018"},{"key":"10.1016\/j.heliyon.2023.e18907_bib19","article-title":"Brucellosis presenting with febrile pancytopenia: an atypical presentation of a common disease and review of brucellosis","volume":"2021","author":"Chang","year":"2021","journal-title":"Case Rep. Infect. Dis."},{"key":"10.1016\/j.heliyon.2023.e18907_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2005.02834.x","article-title":"Clinical uses of intravenous immunoglobulin","volume":"142","author":"Jolles","year":"2005","journal-title":"Clin. Exp. Immunol."},{"issue":"11","key":"10.1016\/j.heliyon.2023.e18907_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/intimm\/dxx039","article-title":"IVIG-mediated effector functions in autoimmune and inflammatory diseases","volume":"29","author":"Galeotti","year":"2017","journal-title":"Int. Immunol."},{"key":"10.1016\/j.heliyon.2023.e18907_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12948-015-0012-1","article-title":"Pidotimod: the state of art","volume":"13","author":"Ferrario","year":"2015","journal-title":"Clin. Mol. Allergy"},{"issue":"5","key":"10.1016\/j.heliyon.2023.e18907_bib23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4103\/lungindia.lungindia_39_19","article-title":"Pidotimod: in-depth review of current evidence","volume":"36","author":"Mahashur","year":"2019","journal-title":"Lung India"},{"issue":"1","key":"10.1016\/j.heliyon.2023.e18907_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s40794-021-00130-w","article-title":"Lack of correlation of Brucella antibody titers with clinical outcomes and culture positivity of brucellosis","volume":"7","author":"Alsubaie","year":"2021","journal-title":"Trop. Dis. Travel Med. Vaccines"},{"issue":"6","key":"10.1016\/j.heliyon.2023.e18907_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.40.6.2313.2002","article-title":"Persistence of Brucella antibodies after successful treatment of acute brucellosis in an area of endemicity","volume":"40","author":"Almuneef","year":"2002","journal-title":"J. Clin. Microbiol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023061157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023061157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:34:21Z","timestamp":1783114461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023061157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2405844023061157"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18907","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of immunomodulatory therapy in a human brucellosis patient with pancytopenia: A case report","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e18907"}}