{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:01:06Z","timestamp":1784930466435,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA001"],"award-info":[{"award-number":["22JR5RA001"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA531"],"award-info":[{"award-number":["23JRRA531"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.heliyon.2023.e19940","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:49:18Z","timestamp":1694555358000},"page":"e19940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The correlation between clinical features and ultrastructure of testis of non-mosaic Klinefelter's syndrome patients with hypogonadism and androgen deficiency: A case report"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-1011","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.heliyon.2023.e19940_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.heliyon.2023.e19940_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1002279","article-title":"In vitro propagation of XXY human Klinefelter spermatogonial stem cells: a step towards new fertility opportunities","volume":"13","author":"Galdon","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF02889055","article-title":"Ultrastructure of Leydig cells in Klinefelter's syndrome with 48, XXYY karyotype","volume":"28","author":"Nistal","year":"1978","journal-title":"Virchows Arch. B Cell Pathol."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/path.1711680111","article-title":"The peritubular myofibroblasts in the testes from normal men and men with Klinefelter's syndrome. A quantitative, ultrastructural, and immunohistochemical study","volume":"168","author":"Martin","year":"1992","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.fertnstert.2022.07.015","article-title":"Morphometric and immunohistochemical analysis as a method to identify undifferentiated spermatogonial cells in adult subjects with Klinefelter syndrome: a cohort study","volume":"118","author":"Deebel","year":"2022","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.heliyon.2023.e19940_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.1711460405","article-title":"Quantitative and ultrastructural study of Leydig cells in Klinefelter's syndrome","volume":"146","author":"Nistal","year":"1985","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0046-8177(82)80132-9","article-title":"Hyperplasia and the immature appearance of Sertoli cells in primary testicular disorders","volume":"13","author":"Nistal","year":"1982","journal-title":"Hum. Pathol."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e19940_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1071\/RD9950237","article-title":"The use of intracytoplasmic sperm injection for the treatment of severe and extreme male infertility","volume":"7","author":"Bourne","year":"1995","journal-title":"Reprod. Fertil. Dev."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e19940_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fertnstert.2015.12.011","article-title":"Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro\/con debate","volume":"105","author":"Gies","year":"2016","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.heliyon.2023.e19940_bib10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/JCMA.0000000000000603","article-title":"The fertility preservation decision-making and testicular sperm retrieval outcome in older adolescents with nonmosaic Klinefelter syndrome and azoospermia","volume":"84","author":"Weng","year":"2021","journal-title":"J. Chin. Med. Assoc."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12894-020-00587-5","article-title":"Do partial AZFc deletions affect the sperm retrieval rate in non-mosaic Klinefelter patients undergoing microdissection testicular sperm extraction","volume":"20","author":"Huang","year":"2020","journal-title":"BMC Urol."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.urology.2006.05.028","article-title":"Aging may adversely affect testicular sperm recovery in patients with Klinefelter syndrome","volume":"68","author":"Emre Bakircioglu","year":"2006","journal-title":"Urology"},{"issue":"6","key":"10.1016\/j.heliyon.2023.e19940_bib13","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.fertnstert.2005.05.053","article-title":"Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndrome","volume":"84","author":"Okada","year":"2005","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib14","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/andr.12067","article-title":"Age and markers of Leydig cell function, but not of Sertoli cell function predict the success of sperm retrieval in adolescents and adults with Klinefelter's syndrome","volume":"3","author":"Rohayem","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.heliyon.2023.e19940_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.urology.2021.12.012","article-title":"Predictive factors and intracytoplasmic sperm injection results for sperm retrieval by microdissection testicular sperm extraction (micro-TESE) in patients with klinefelter syndrome","volume":"161","author":"\u00d6zkan","year":"2022","journal-title":"Urology"},{"key":"10.1016\/j.heliyon.2023.e19940_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jpeds.2015.12.028","article-title":"Sperm retrieval in adolescents and young adults with klinefelter syndrome: a prospective, pilot study","volume":"170","author":"Nahata","year":"2016","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e19940_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/1008-682X.122201","article-title":"The role of hypogonadism in Klinefelter syndrome","volume":"16","author":"H\u00f8st","year":"2014","journal-title":"Asian J. Androl."},{"issue":"4","key":"10.1016\/j.heliyon.2023.e19940_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.14310\/horm.2002.1622","article-title":"Klinefelter Syndrome and medical treatment: hypogonadism and beyond","volume":"14","author":"Chang","year":"2015","journal-title":"Hormones (Basel)"},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib19","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2012.07.1122","article-title":"Prevalence and risk factors of diabetes in patients with Klinefelter syndrome: a longitudinal observational study","volume":"98","author":"Jiang-Feng","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.heliyon.2023.e19940_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jpeds.2019.08.055","article-title":"50 Years ago in TheJournal ofPediatrics: the effects of testosterone treatment in klinefelter's syndrome","volume":"217","author":"Almutlaq","year":"2020","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e19940_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0022-3476(70)80173-1","article-title":"The effects of testosterone treatment in Klinefelter's syndrome","volume":"76","author":"Myhre","year":"1970","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib22","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s40618-020-01400-8","article-title":"Quality of life in Klinefelter patients on testosterone replacement therapy compared to healthy controls: an observational study on the impact of psychological distress, personality traits, and coping strategies","volume":"44","author":"Fabrazzo","year":"2021","journal-title":"J. Endocrinol. Invest."},{"issue":"9","key":"10.1016\/j.heliyon.2023.e19940_bib23","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s40618-022-01816-4","article-title":"First baseline data of the Klinefelter Italian Group (KING) cohort: clinical features of adult with Klinefelter syndrome in Italy","volume":"45","author":"Pasquali","year":"2022","journal-title":"J. Endocrinol. Invest."},{"issue":"3","key":"10.1016\/j.heliyon.2023.e19940_bib24","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jpeds.2015.06.037","article-title":"Phenotype and adverse quality of life in boys with klinefelter syndrome","volume":"167","author":"Close","year":"2015","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/humupd\/dmac016","article-title":"Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis","volume":"28","author":"Tharakan","year":"2022","journal-title":"Hum. Reprod. Update"},{"issue":"6","key":"10.1016\/j.heliyon.2023.e19940_bib26","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/andr.12249","article-title":"Testicular function during puberty and young adulthood in patients with Klinefelter's syndrome with and without spermatozoa in seminal fluid","volume":"4","author":"Rohayem","year":"2016","journal-title":"Andrology"},{"issue":"7","key":"10.1016\/j.heliyon.2023.e19940_bib27","first-page":"637","article-title":"Predictive factors for clinical pregnancy in patients with nonmosaic Klinefelter's syndrome undergoing microdissection testicular sperm extraction","volume":"25","author":"Yang","year":"2019","journal-title":"Zhonghua Nan ke Xue"},{"issue":"12","key":"10.1016\/j.heliyon.2023.e19940_bib28","first-page":"1075","article-title":"Microdissection testicular sperm extraction for patients with nonmosaic Klinefelter syndrome: a report of 143 cases","volume":"23","author":"Mao","year":"2017","journal-title":"Zhonghua Nan ke Xue"},{"issue":"3","key":"10.1016\/j.heliyon.2023.e19940_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ando.2022.05.002","article-title":"Fertility in men with Klinefelter's syndrome","volume":"83","author":"Plotton","year":"2022","journal-title":"Ann. Endocrinol."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/jsm.12277","article-title":"Is testosterone replacement therapy in males with hypogonadism cost-effective? An analysis in Sweden","volume":"11","author":"Arver","year":"2014","journal-title":"J. Sex. Med."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e19940_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/andr.12909","article-title":"European Academy of Andrology guidelines on klinefelter syndrome endorsing organization: European society of endocrinology","volume":"9","author":"Zitzmann","year":"2021","journal-title":"Andrology"},{"issue":"5","key":"10.1016\/j.heliyon.2023.e19940_bib32","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/andr.12770","article-title":"European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: endorsing organization: European Society of Endocrinology","volume":"8","author":"Corona","year":"2020","journal-title":"Andrology"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023071487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023071487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:04:53Z","timestamp":1784927093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023071487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2405844023071487"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19940","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The correlation between clinical features and ultrastructure of testis of non-mosaic Klinefelter's syndrome patients with hypogonadism and androgen deficiency: A case report","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e19940"}}