{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:04:18Z","timestamp":1784930658749,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1\u2013005"],"award-info":[{"award-number":["2021-I2M-1\u2013005"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFC0907601"],"award-info":[{"award-number":["2017YFC0907601"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFC0907604"],"award-info":[{"award-number":["2017YFC0907604"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFC08040603"],"award-info":[{"award-number":["2019YFC08040603"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.heliyon.2023.e20105","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:35:46Z","timestamp":1694644546000},"page":"e20105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Carboxyamidotriazole alleviates pannus formation and cartilage erosion in rats with adjuvant arthritis"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-3689","authenticated-orcid":false,"given":"Yongting","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-1663","authenticated-orcid":false,"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2023.e20105_bib1","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1002\/art.27692","article-title":"Long-term impact of delay in assessment of patients with early arthritis","volume":"62","author":"van der Linden","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.heliyon.2023.e20105_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","article-title":"Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib4","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/art.22707","article-title":"Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis","volume":"56","author":"Huang","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.heliyon.2023.e20105_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41419-020-2314-6","article-title":"NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heliyon.2023.e20105_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.heliyon.2023.e20105_bib7","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.4049\/jimmunol.0904068","article-title":"Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function","volume":"184","author":"Sabeh","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13075-017-1303-3","article-title":"Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis","volume":"19","author":"Bustamante","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.heliyon.2023.e20105_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tips.2015.02.001","article-title":"Novel therapeutic targets in rheumatoid arthritis","volume":"36","author":"Koenders","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.heliyon.2023.e20105_bib10","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1111\/bph.13138","article-title":"Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis","volume":"172","author":"Zhu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib11","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3892\/etm.2020.8889","article-title":"Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-\u03baB and MAPKs pathways","volume":"20","author":"Lu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.heliyon.2023.e20105_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jep.2008.08.031","article-title":"Therapeutic effects of daphnetin on adjuvant-induced arthritic rats","volume":"120","author":"Gao","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00011-005-1345-x","article-title":"Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis","volume":"54","author":"Zhu","year":"2005","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.heliyon.2023.e20105_bib14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"Suppl 3","key":"10.1016\/j.heliyon.2023.e20105_bib15","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.heliyon.2023.e20105_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.heliyon.2023.e20105_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1097-0215(19961009)68:2<259::AID-IJC20>3.0.CO;2-4","article-title":"Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines","volume":"68","author":"Wasilenko","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heliyon.2023.e20105_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0169-5002(02)00525-1","article-title":"CAI inhibits the growth of small cell lung cancer cells","volume":"39","author":"Moody","year":"2003","journal-title":"Lung Cancer"},{"key":"10.1016\/j.heliyon.2023.e20105_bib19","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1200\/JCO.2003.04.136","article-title":"Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer","volume":"21","author":"Hussain","year":"2003","journal-title":"J. Clin. Oncol. : Official Journal of the American Society of Clinical Oncology"},{"key":"10.1016\/j.heliyon.2023.e20105_bib20","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/cncr.21473","article-title":"Phase II study of carboxyamidotriazole in patients with advanced renal cell carcinoma refractory to immunotherapy: E4896, an Eastern Cooperative Oncology Group Study","volume":"104","author":"Dutcher","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.heliyon.2023.e20105_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10637-006-9023-6","article-title":"Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme","volume":"25","author":"Mikkelsen","year":"2007","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.heliyon.2023.e20105_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2017.01.015","article-title":"Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-kappaB activation","volume":"45","author":"Du","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20105_bib23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ejca.2011.06.050","article-title":"Inhibition of pro-inflammatory cytokines in tumour associated macrophages is a potential anti-cancer mechanism of carboxyamidotriazole","volume":"48","author":"Ju","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.heliyon.2023.e20105_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pathophys.2005.07.011","article-title":"Animal models of rheumatoid arthritis and their relevance to human disease","volume":"12","author":"Kannan","year":"2005","journal-title":"Pathophysiology"},{"key":"10.1016\/j.heliyon.2023.e20105_bib25","first-page":"49","article-title":"Therapeutic effect of carboxyamidotriazole on adjuvant arthritis in rats","volume":"38","author":"Zhu","year":"2016","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"10.1016\/j.heliyon.2023.e20105_bib26","doi-asserted-by":"crossref","first-page":"174500","DOI":"10.1016\/j.ejphar.2021.174500","article-title":"Angiogenesis as a potential treatment strategy for rheumatoid arthritis","volume":"910","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.heliyon.2023.e20105_bib28","doi-asserted-by":"crossref","first-page":"9378","DOI":"10.1111\/jcmm.16877","article-title":"Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling","volume":"25","author":"Chen","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.heliyon.2023.e20105_bib29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/art.21662","article-title":"CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway","volume":"54","author":"Ruth","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.heliyon.2023.e20105_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.148.2.333","article-title":"Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts","volume":"148","author":"Miyazaki","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib31","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1074\/jbc.M001229200","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)","volume":"275","author":"Matsumoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2023.e20105_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108793","article-title":"Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis","volume":"230","author":"Liu","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.heliyon.2023.e20105_bib33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.autrev.2011.04.020","article-title":"Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation?","volume":"10","author":"Marrelli","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.heliyon.2023.e20105_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/ard.61.9.804","article-title":"Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis","volume":"61","author":"Klimiuk","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.heliyon.2023.e20105_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13075-019-2088-3","article-title":"Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis","volume":"21","author":"Fromm","year":"2019","journal-title":"Arthritis Res. Ther."},{"issue":"Suppl 3","key":"10.1016\/j.heliyon.2023.e20105_bib36","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1186\/ar572","article-title":"Matrix metalloproteinases in arthritic disease","volume":"4","author":"Murphy","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.heliyon.2023.e20105_bib37","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/ard.61.11.975","article-title":"Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10","volume":"61","author":"Tolboom","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.heliyon.2023.e20105_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/ar401","article-title":"Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors","volume":"4","author":"Vincenti","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.heliyon.2023.e20105_bib39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol. Med."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023073139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023073139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:23:15Z","timestamp":1784928195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023073139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2405844023073139"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20105","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carboxyamidotriazole alleviates pannus formation and cartilage erosion in rats with adjuvant arthritis","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e20105"}}