{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:58:20Z","timestamp":1789610300507,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000019"],"award-info":[{"award-number":["32000019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174238"],"award-info":[{"award-number":["82174238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.heliyon.2023.e20149","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:37:07Z","timestamp":1694644627000},"page":"e20149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Angong niuhuang wan attenuates LPS-induced acute lung injury by inhibiting PIK3CG\/p65\/MMP9 signaling in mice based on proteomics"],"prefix":"10.1016","volume":"9","author":[{"given":"Sen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2023.e20149_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/CS20210879","article-title":"Pathogenesis of pneumonia and acute lung injury","volume":"136","author":"Long","year":"2022","journal-title":"Clin. Sci. (London, England: 1979)"},{"key":"10.1016\/j.heliyon.2023.e20149_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108782","article-title":"Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2\/HO-1 signaling axis","volume":"109","author":"Kang","year":"2022","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00134-020-06331-9","article-title":"Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19","volume":"47","author":"Shaefi","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.heliyon.2023.e20149_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1517\/14728214.2015.1000299","article-title":"Emerging drugs for acute lung injury","volume":"20","author":"Impellizzeri","year":"2015","journal-title":"Expet Opin. Emerg. Drugs."},{"key":"10.1016\/j.heliyon.2023.e20149_bib5","article-title":"Comparative efficacy of seven kinds of Chinese medicine injections in acute lung injury and acute respiratory distress syndrome: a network meta-analysis of randomized controlled trials","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biopha.2017.09.094","article-title":"Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4\/NF-\u03baB pathway","volume":"96","author":"Deng","year":"2017","journal-title":"Biome Pharmacother."},{"key":"10.1016\/j.heliyon.2023.e20149_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12138","article-title":"The traditional Chinese patented medicine Qingke Pingchuan granules alleviate acute lung injury by regenerating club cells","volume":"12","author":"Wu","year":"2022","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.heliyon.2023.e20149_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9747212","article-title":"Protective effects of angong Niuhuang pill on early atherosclerosis in ApoE(-\/-) mice by reducing the inflammatory response, evidence-based complementary and alternative medicine","volume":"2019","author":"Chai","year":"2019","journal-title":"Evid Based Complement Alternat Med."},{"key":"10.1016\/j.heliyon.2023.e20149_bib9","article-title":"Angong Niuhuang Pill ameliorates cerebral ischemia\/reperfusion injury in mice partly by restoring gut microbiota dysbiosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13020-022-00595-7","article-title":"Angong Niuhuang Wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated MMP-9 activation","volume":"17","author":"Chen","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.heliyon.2023.e20149_bib11","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3389\/fphar.2019.01584","article-title":"Anti-atherosclerosis effect of angong Niuhuang pill via regulating Th17\/treg immune balance and inhibiting chronic inflammatory on ApoE(-\/-) mice model of early and mid-term atherosclerosis","volume":"10","author":"Fan","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib12","first-page":"3333","article-title":"[Realgar is active ingredient of Angong Niuhuang pill in protection against LPS-induced neuroinflammation]","volume":"35","author":"Zhang","year":"2010","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.heliyon.2023.e20149_bib13","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3389\/fphar.2020.01066","article-title":"Chinese patent medicines in the treatment of coronavirus disease 2019 (COVID-19) in China","volume":"11","author":"Zhuang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.intimp.2015.03.031","article-title":"Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-\u03baB signal pathways","volume":"26","author":"Zhang","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110282","article-title":"Melatonin attenuates lipopolysaccharide-induced immune dysfunction in dendritic cells","volume":"120","author":"Qin","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib16","series-title":"A Whole Blood Proteomics Analysis Method","author":"Li","year":"2022"},{"key":"10.1016\/j.heliyon.2023.e20149_bib17","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1021\/acs.jproteome.1c00971","article-title":"Proteomic analysis of whole blood using volumetric absorptive microsampling for precision medicine biomarker studies","volume":"21","author":"Molloy","year":"2022","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.heliyon.2023.e20149_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"key":"10.1016\/j.heliyon.2023.e20149_bib19","first-page":"3633","article-title":"[Exploiture and application of an internet-based computation platform for integrative pharmacology of traditional Chinese medicine]","volume":"42","author":"Xu","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.heliyon.2023.e20149_bib20","article-title":"An integrative pharmacology-based approach for evaluating the potential effects of purslane seed in diabetes mellitus treatment using UHPLC-LTQ-orbitrap and TCMIP V2.0","volume":"11","author":"Hou","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/acscentsci.1c00866","article-title":"Fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury","volume":"8","author":"Yuan","year":"2022","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.heliyon.2023.e20149_bib22","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1097\/CCM.0000000000004155","article-title":"The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey","volume":"48","author":"Xie","year":"2020","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.heliyon.2023.e20149_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911740","article-title":"Cytokine storm-definition, causes, and implications","volume":"23","author":"Jarczak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2023.e20149_bib24","article-title":"Nasal delivery of hesperidin\/chitosan nanoparticles suppresses cytokine storm syndrome in a mouse model of acute lung injury","volume":"11","author":"Jin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1440-1681.13620","article-title":"Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R\/JAK\/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology","volume":"49","author":"Al-Ani","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/1753466620933508","article-title":"Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications","volume":"14","author":"Pelaia","year":"2020","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.heliyon.2023.e20149_bib27","first-page":"1888","article-title":"[Effects of Angong Niuhuang Pills against heart failure based on cross-scale polypharmacological study]","volume":"47","author":"Shi","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.heliyon.2023.e20149_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jep.2016.11.015","article-title":"Anti-atherosclerosis and cardio-protective effects of the Angong Niuhuang Pill on a high fat and vitamin D3 induced rodent model of atherosclerosis","volume":"195","author":"Fu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mcn.2017.02.001","article-title":"A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth","volume":"80","author":"Hamilton","year":"2017","journal-title":"Mol Cell Neurosci."},{"key":"10.1016\/j.heliyon.2023.e20149_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3389\/fphar.2019.00593","article-title":"Neuroprotective effects and hepatorenal toxicity of angong Niuhuang wan against ischemia-reperfusion brain injury in rats","volume":"10","author":"Tsoi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10875-011-9628-1","article-title":"PI3K-\u03b3 inhibition ameliorates acute lung injury through regulation of I\u03baB\u03b1\/NF-\u03baB pathway and innate immune responses","volume":"32","author":"Kim","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib32","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41401-020-00502-6","article-title":"Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.heliyon.2023.e20149_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106676","article-title":"Effect of curcumin on IL-17A mediated pulmonary AMPK kinase\/cyclooxygenase-2 expressions via activation of NF\u03baB in bleomycin-induced acute lung injury in vivo","volume":"85","author":"Shaikh","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib34","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00210-019-01680-9","article-title":"Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway","volume":"392","author":"Meng","year":"2019","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e20149_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8414062","article-title":"Baicalin liposome alleviates lipopolysaccharide-induced acute lung injury in mice via inhibiting TLR4\/JNK\/ERK\/NF-\u03baB pathway","volume":"2020","author":"Long","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153784","article-title":"Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-\u03baB signaling pathway","volume":"95","author":"Feng","year":"2022","journal-title":"Phytomedicine."},{"key":"10.1016\/j.heliyon.2023.e20149_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.intimp.2012.07.007","article-title":"Kaempferol regulates MAPKs and NF-\u03baB signaling pathways to attenuate LPS-induced acute lung injury in mice","volume":"14","author":"Chen","year":"2012","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e20149_bib38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ejphar.2011.08.029","article-title":"Suppression of NF-\u03baB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice","volume":"674","author":"Yang","year":"2012","journal-title":"Eur. J. Pharmacol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023073577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023073577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:17:24Z","timestamp":1784927844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023073577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2405844023073577"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20149","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angong niuhuang wan attenuates LPS-induced acute lung injury by inhibiting PIK3CG\/p65\/MMP9 signaling in mice based on proteomics","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e20149"}}