{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:00:22Z","timestamp":1791295222496,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016694","name":"Science and Technology Development Plan of Shandong Province","doi-asserted-by":"publisher","award":["2022SF-435"],"award-info":[{"award-number":["2022SF-435"]}],"id":[{"id":"10.13039\/100016694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800401"],"award-info":[{"award-number":["81800401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.heliyon.2023.e21745","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T03:00:59Z","timestamp":1699066859000},"page":"e21745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Shuangshi Tonglin capsule improves chronic prostatitis through the SIRT-1\/AMPK and MAPK signalling pathways"],"prefix":"10.1016","volume":"9","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.heliyon.2023.e21745_bib1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0022-5347(05)66541-X","article-title":"Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index","volume":"165","author":"Nickel","year":"2001","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.eururo.2008.03.073","article-title":"Chronic pelvic pain and lower urinary tract symptoms in both sexes: analysis of 2749 participants of an urban health screening project","volume":"55","author":"Marszalek","year":"2009","journal-title":"Eur. Urol."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.21037\/atm.2016.12.32","article-title":"Gut microbiome and chronic prostatitis\/chronic pelvic pain syndrome","volume":"5","author":"Arora","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.heliyon.2023.e21745_bib4","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.biopha.2017.08.016","article-title":"Comprehensive overview of prostatitis","volume":"94","author":"Khan","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib5","first-page":"216","article-title":"Clinical observation of Shuangshitonglin Capsule treating chronic prostatitis","volume":"37","author":"Jin","year":"2016","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"issue":"20","key":"10.1016\/j.heliyon.2023.e21745_bib6","first-page":"3121","article-title":"Clinical effect of Shuangshitonglin Capsule on chronic pelvic pain syndrome","volume":"26","author":"He","year":"2020","journal-title":"International Medicine and Health Guidance News"},{"key":"10.1016\/j.heliyon.2023.e21745_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.intimp.2018.11.020","article-title":"Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells","volume":"66","author":"Hu","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e21745_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7621929","article-title":"Phellodendri cortex: a phytochemical, pharmacological, and pharmacokinetic review","volume":"2019","author":"Sun","year":"2019","journal-title":"Evid-Based Compl Alt"},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.intimp.2014.01.020","article-title":"The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro: down-regulation of NO and iNOS through suppression of NF-kappaB and MAPK activation","volume":"19","author":"Choi","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.heliyon.2023.e21745_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5763602","article-title":"Recent advances in the pharmacological activities of dioscin","volume":"2019","author":"Yang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.heliyon.2023.e21745_bib11","first-page":"1","article-title":"A novel flavonoid with antioxidant activity from Patrinia villosa (Thunb.) Juss","author":"Liu","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.heliyon.2023.e21745_bib12","article-title":"Salvia miltiorrhiza Bge. (Danshen) for inflammatory bowel disease: clinical evidence and network pharmacology-based strategy for developing supplementary medical application","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.heliyon.2023.e21745_bib13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/pros.23995","article-title":"The effect of pirfenidone on rat chronic prostatitis\/chronic pelvic pain syndrome and its mechanisms","volume":"80","author":"Peng","year":"2020","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.heliyon.2023.e21745_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"issue":"13","key":"10.1016\/j.heliyon.2023.e21745_bib15","first-page":"5","article-title":"Effect of shuangshitonglin capsule on nonbacterial prostatitis","volume":"4","author":"Liu","year":"2019","journal-title":"Clinical Research and Practice"},{"key":"10.1016\/j.heliyon.2023.e21745_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.biopha.2017.04.055","article-title":"Therapeutic effect of melittin on a rat model of chronic prostatitis induced by Complete Freund's Adjuvant","volume":"90","author":"Lin","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e21745_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pupt.2012.05.006","article-title":"Pro-inflammatory and immunomodulatory functions of airway smooth muscle: emerging concepts","volume":"26","author":"Xia","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"14","key":"10.1016\/j.heliyon.2023.e21745_bib18","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.heliyon.2023.e21745_bib19","first-page":"112","article-title":"Effects of ShenlingBaizhu Powder on hemorheological indexes and serum levels of TNF-\u03b1, IL-2 and IL-6 in patients with chronic prostatitis","volume":"4","author":"Zhu","year":"2020","journal-title":"Modern Medicine and Health Research Electronic Journal"},{"issue":"1","key":"10.1016\/j.heliyon.2023.e21745_bib20","first-page":"51","article-title":"Effects of Rhizoma Fenxianxinzhuishinshi Decoction on chronic prostatitis and levels of NIH-CPSI score, IFN-\u03b3, TNF-\u03b1 and IL-4","volume":"39","author":"Zeng","year":"2020","journal-title":"Journal of Tianjin University of Traditional Chinese Medicine"},{"issue":"3","key":"10.1016\/j.heliyon.2023.e21745_bib21","first-page":"75","article-title":"Study on correlation between TCM syndrome type and IL-1\u03b2 and TNF-\u03b1 in chronic prostatitis","volume":"32","author":"Chen","year":"2015","journal-title":"Information on Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.heliyon.2023.e21745_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state","volume":"15","author":"Kurutas","year":"2016","journal-title":"Nutr. J."},{"issue":"3","key":"10.1016\/j.heliyon.2023.e21745_bib23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/andr.12747","article-title":"Lycopene attenuates chronic prostatitis\/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-kappaB, MAPKs, and Nrf2 signaling pathways in rats","volume":"8","author":"Zhao","year":"2020","journal-title":"Andrology-Us."},{"issue":"5","key":"10.1016\/j.heliyon.2023.e21745_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/and.13245","article-title":"Jiedu Huoxue decoction improves inflammation in rat type III prostatitis: the importance of the NF-kappaB signalling pathway","volume":"51","author":"Yan","year":"2019","journal-title":"Andrologia"},{"issue":"11","key":"10.1016\/j.heliyon.2023.e21745_bib25","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/pros.23536","article-title":"Quercetin protects against chronic prostatitis in rat model through NF-kappaB and MAPK signaling pathways","volume":"78","author":"Meng","year":"2018","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00011-009-0077-8","article-title":"Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages","volume":"59","author":"Feng","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.heliyon.2023.e21745_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-kappaB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"issue":"25","key":"10.1016\/j.heliyon.2023.e21745_bib28","doi-asserted-by":"crossref","first-page":"19051","DOI":"10.1074\/jbc.M110.123620","article-title":"Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1","volume":"285","author":"Yang","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.heliyon.2023.e21745_bib29","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1096\/fj.10-160549","article-title":"p53 and NF-kappaB: different strategies for responding to stress lead to a functional antagonism","volume":"24","author":"Ak","year":"2010","journal-title":"Faseb. J."},{"issue":"2","key":"10.1016\/j.heliyon.2023.e21745_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2004.06.016","article-title":"Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a","volume":"21","author":"Lin","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.heliyon.2023.e21745_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuint.2019.04.002","article-title":"Activation of liver x receptors prevents the spinal LTP induced by skin\/muscle retraction in the thigh via SIRT1\/NF-Kappab pathway","volume":"128","author":"Zhong","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.heliyon.2023.e21745_bib32","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2147\/JPR.S298727","article-title":"Quercetin alleviates neuropathic pain in the rat CCI model by mediating AMPK\/MAPK pathway","volume":"14","author":"Ye","year":"2021","journal-title":"J. Pain Res."},{"issue":"1","key":"10.1016\/j.heliyon.2023.e21745_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jcmm.16058","article-title":"Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti-inflammation property and AMPK\/MAPK\/NF-kB inhibition","volume":"25","author":"Xu","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"20","key":"10.1016\/j.heliyon.2023.e21745_bib34","doi-asserted-by":"crossref","first-page":"23780","DOI":"10.18632\/aging.203649","article-title":"Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-kappaB pathways through up-regulating AMPK","volume":"13","author":"Wu","year":"2021","journal-title":"Aging (Albany NY)"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023089533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023089533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:20:28Z","timestamp":1791292828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023089533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2405844023089533"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e21745","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shuangshi Tonglin capsule improves chronic prostatitis through the SIRT-1\/AMPK and MAPK signalling pathways","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e21745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e21745"}}