{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:59:49Z","timestamp":1791295189360,"version":"4.1.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2023ZYYC053"],"award-info":[{"award-number":["2023ZYYC053"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020771","name":"Natural Science Foundation for Young Scientists of Shanxi Province","doi-asserted-by":"publisher","award":["202203021212071"],"award-info":[{"award-number":["202203021212071"]}],"id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.heliyon.2023.e22307","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:48:18Z","timestamp":1699973298000},"page":"e22307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Roles and mechanisms of long non-coding RNAs in age-related macular degeneration"],"prefix":"10.1016","volume":"9","author":[{"given":"Rong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-7867","authenticated-orcid":false,"given":"Guohong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2023.e22307_bib1","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1167\/iovs.16-20001","article-title":"Functional outcomes of the Low vision Depression prevention trial in age-related macular degeneration","volume":"58","author":"Deemer","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.heliyon.2023.e22307_bib3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1755-3768.2012.02399.x","article-title":"Projected prevalence of age-related macular degeneration in Scandinavia 2012-2040","volume":"91","author":"Lindekleiv","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib4","first-page":"493","article-title":"Updates on the Epidemiology of age-related macular degeneration","volume":"6","author":"Jonas","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"10.1016\/j.heliyon.2023.e22307_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.preteyeres.2016.04.002","article-title":"Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians","volume":"53","author":"Wong","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.exer.2008.09.021","article-title":"Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells","volume":"88","author":"Al-Hussaini","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/path.4266","article-title":"Mechanisms of age-related macular degeneration and therapeutic opportunities","volume":"232","author":"van Lookeren Campagne","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2012.10.018","article-title":"Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lecture","volume":"155","author":"Miller","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/bjophthalmol-2020-318452","article-title":"Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions","volume":"106","author":"Cabral de Guimaraes","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2174\/0929867326666190711105325","article-title":"Anti-VEGF treatment and response in age-related macular degeneration: Disease's Susceptibility, Pharmacogenetics and Pharmacokinetics","volume":"27","author":"Maronas","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.heliyon.2023.e22307_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092483","article-title":"Potential therapeutic Candidates for age-related macular degeneration (AMD)","volume":"10","author":"Nashine","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.heliyon.2023.e22307_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj2177","article-title":"Targeting C3b\/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy","volume":"14","author":"Yang","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.heliyon.2023.e22307_bib13","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1101\/gad.1800909","article-title":"Long noncoding RNAs: functional surprises from the RNA world","volume":"23","author":"Wilusz","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.heliyon.2023.e22307_bib14","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2019.04.011","article-title":"Long non-coding RNA: Classification, biogenesis and functions in blood cells","volume":"112","author":"Dahariya","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41556-019-0311-8","article-title":"Cellular functions of long noncoding RNAs","volume":"21","author":"Yao","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","article-title":"LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury","volume":"27","author":"Wan","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.heliyon.2023.e22307_bib18","first-page":"1329","article-title":"Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients","volume":"19","author":"Zheng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.heliyon.2023.e22307_bib19","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1007\/s11033-014-3320-5","article-title":"Long non-coding RNAs: new players in ocular neovascularization","volume":"41","author":"Xu","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.heliyon.2023.e22307_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179178","article-title":"Potential of long non-coding RNAs in age-related macular degeneration","volume":"22","author":"Blasiak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbrc.2020.10.104","article-title":"Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration","volume":"535","author":"Yu","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heliyon.2023.e22307_bib22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.omtn.2019.12.040","article-title":"LINC00167 regulates RPE differentiation by targeting the miR-203a-3p\/SOCS3 Axis","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.heliyon.2023.e22307_bib23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s12864-022-08777-1","article-title":"Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions","volume":"23","author":"Kaczynski","year":"2022","journal-title":"BMC Genom."},{"key":"10.1016\/j.heliyon.2023.e22307_bib24","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41418-021-00756-5","article-title":"Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy","volume":"28","author":"Yang","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.heliyon.2023.e22307_bib25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s10528-021-10072-9","article-title":"lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation through the miR-7-5p\/Pax6 Axis","volume":"59","author":"Sun","year":"2021","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.heliyon.2023.e22307_bib26","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1080\/21655979.2021.1933821","article-title":"Long non-coding RNA histone deacetylase 4 antisense RNA 1 (HDAC4-AS1) inhibits HDAC4 expression in human ARPE-19 cells with hypoxic stress","volume":"12","author":"Pan","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.heliyon.2023.e22307_bib27","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3389\/fphar.2018.01280","article-title":"Oxidative stress in age-related macular degeneration: Nrf2 as therapeutic target","volume":"9","author":"Bellezza","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101201","article-title":"Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors","volume":"24","author":"Brown","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0014-4835(03)00023-X","article-title":"Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration","volume":"76","author":"Liang","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111755","article-title":"The role of NAD+ metabolism in macrophages in age-related macular degeneration","volume":"209","author":"Lin","year":"2023","journal-title":"Mechanisms of ageing and development"},{"key":"10.1016\/j.heliyon.2023.e22307_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9040318","article-title":"Transcriptome Analyses of lncRNAs in A2E-Stressed retinal epithelial cells Unveil advanced links between metabolic impairments related to oxidative stress and retinitis Pigmentosa","volume":"9","author":"Donato","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.heliyon.2023.e22307_bib32","first-page":"206","article-title":"Clinico-morphologic correlations of drusen of Bruch's membrane","volume":"78","author":"Burns","year":"1980","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.heliyon.2023.e22307_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0039-6257(99)00072-7","article-title":"Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression","volume":"44","author":"Abdelsalam","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib34","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.2147\/IJN.S140275","article-title":"Identification of lncRNAs involved in biological regulation in early age-related macular degeneration","volume":"12","author":"Zhu","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.heliyon.2023.e22307_bib35","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1002\/jnr.22046","article-title":"Neuroprotective role of erythropoietin by antiapoptosis in the retina","volume":"87","author":"Chung","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib36","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bbrc.2018.01.177","article-title":"Long non-coding RNA MEG3 silencing protects against light-induced retinal degeneration","volume":"496","author":"Zhu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heliyon.2023.e22307_bib37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ajo.2021.03.010","article-title":"Peripheral monocyte Count and age-related macular degeneration. The Tongren health Care study","volume":"227","author":"Xue","year":"2021","journal-title":"Am. J. Ophthalmol."},{"issue":"Pt 4","key":"10.1016\/j.heliyon.2023.e22307_bib38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/eye.1990.86","article-title":"Macrophages related to Bruch's membrane in age-related macular degeneration","volume":"4","author":"Killingsworth","year":"1990","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.heliyon.2023.e22307_bib39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/eye.2008.206","article-title":"Macrophages in neovascular age-related macular degeneration: friends or foes?","volume":"23","author":"Skeie","year":"2009","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.heliyon.2023.e22307_bib40","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/bjo.2009.165563","article-title":"Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration","volume":"94","author":"Cherepanoff","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib41","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00417-015-3094-z","article-title":"Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration","volume":"253","author":"Lad","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15252\/emmm.201404524","article-title":"Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration","volume":"7","author":"Levy","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.heliyon.2023.e22307_bib43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mam.2012.04.006","article-title":"Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration","volume":"33","author":"Mettu","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.heliyon.2023.e22307_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100906","article-title":"Incomplete response to Anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities","volume":"82","author":"Mettu","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7150\/ijms.37804","article-title":"Altered long non-coding RNAs involved in Immunological regulation and associated with choroidal neovascularization in mice","volume":"17","author":"Zhang","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/intimm\/dxy028","article-title":"Mincle: 20 years of a versatile sensor of insults","volume":"30","author":"Lu","year":"2018","journal-title":"Int. Immunol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib47","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1080\/02713683.2020.1748659","article-title":"Analysis of long noncoding RNAs in choroid neovascularization","volume":"45","author":"Zhang","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib48","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.heliyon.2023.e22307_bib49","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nature14897","article-title":"Distinct EMT programs control normal mammary stem cells and tumour-initiating cells","volume":"525","author":"Ye","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2023.e22307_bib50","doi-asserted-by":"crossref","first-page":"AMD104","DOI":"10.1167\/iovs.18-24132","article-title":"A role for \u03b2A3\/A1-Crystallin in type 2 EMT of RPE cells occurring in dry age-related macular degeneration","volume":"59","author":"Ghosh","year":"2018","journal-title":"Investigative ophthalmology & visual science"},{"key":"10.1016\/j.heliyon.2023.e22307_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124271","article-title":"EMT and EndMT: emerging roles in age-related macular degeneration","volume":"21","author":"Shu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exer.2015.03.009","article-title":"Molecular mechanisms of subretinal fibrosis in age-related macular degeneration","volume":"142","author":"Ishikawa","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib53","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1158\/1535-7163.MCT-15-0751","article-title":"TWIST1 Polymorphisms Predict survival in patients with Metastatic Colorectal Cancer Receiving First-Line bevacizumab plus Oxaliplatin-based Chemotherapy","volume":"15","author":"Matsusaka","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.heliyon.2023.e22307_bib54","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12974-022-02546-3","article-title":"Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells","volume":"19","author":"Llori\u00e1n-Salvador","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.heliyon.2023.e22307_bib55","article-title":"Long non-coding RNA MALAT1 mediates transforming growth factor Beta1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2023.e22307_bib56","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11817","article-title":"LncRNA NEAT1 regulated diabetic retinal epithelial-mesenchymal transition through regulating miR-204\/SOX4 axis","volume":"9","author":"Yang","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.heliyon.2023.e22307_bib57","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molcel.2014.03.030","article-title":"Stress, inflammation, and defense of homeostasis","volume":"54","author":"Chovatiya","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.heliyon.2023.e22307_bib58","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","volume":"73","author":"Kauppinen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.9.8.1","article-title":"Lamivudine inhibits Alu RNA-induced retinal pigment epithelium degeneration via anti-inflammatory and anti-senescence Activities","volume":"9","author":"Yamada","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.heliyon.2023.e22307_bib60","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cyto.2017.10.009","article-title":"Proinflammatory cytokine interferon-gamma increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cells","volume":"104","author":"Kutty","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.heliyon.2023.e22307_bib61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrm3043","article-title":"Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration","volume":"12","author":"Jopling","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib62","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1172\/JCI44303","article-title":"mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice","volume":"121","author":"Zhao","year":"2011","journal-title":"The Journal of clinical investigation"},{"key":"10.1016\/j.heliyon.2023.e22307_bib63","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ymthe.2020.01.010","article-title":"Circular noncoding RNA NR3C1 acts as a miR-382-5p sponge to protect RPE functions via regulating PTEN\/AKT\/mTOR signaling pathway","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther. : the journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.heliyon.2023.e22307_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.382","article-title":"LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heliyon.2023.e22307_bib65","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng0496-363","article-title":"Creation of genomic methylation patterns","volume":"12","author":"Bestor","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heliyon.2023.e22307_bib66","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.heliyon.2023.e22307_bib67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuint.2018.09.001","article-title":"DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells","volume":"121","author":"Huang","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.heliyon.2023.e22307_bib68","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1038\/cddis.2012.165","article-title":"Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival","volume":"3","author":"Rhee","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heliyon.2023.e22307_bib69","doi-asserted-by":"crossref","first-page":"E598","DOI":"10.1152\/ajpendo.00089.2020","article-title":"DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K\/Akt\/mTOR signaling pathway","volume":"320","author":"He","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.heliyon.2023.e22307_bib70","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.ajpath.2020.05.008","article-title":"Long noncoding RNA MEG3 inhibits apoptosis of retinal pigment epithelium cells induced by high glucose via the miR-93\/Nrf2 Axis","volume":"190","author":"Luo","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.heliyon.2023.e22307_bib71","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.omtn.2020.01.011","article-title":"Mbd2 mediates retinal cell apoptosis by targeting the lncRNA Mbd2-AL1\/miR-188-3p\/Traf3 Axis in ischemia\/reperfusion injury","volume":"19","author":"Ge","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.heliyon.2023.e22307_bib72","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1194\/jlr.M073684","article-title":"Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration","volume":"58","author":"Cheung","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib73","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2017.09.008","article-title":"Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells","volume":"165","author":"Storti","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib74","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1093\/hmg\/ddx319","article-title":"Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration","volume":"26","author":"Biswas","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.heliyon.2023.e22307_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/802059","article-title":"Lipids, lipoproteins, and age-related macular degeneration","volume":"2011","author":"Ebrahimi","year":"2011","journal-title":"J Lipids"},{"key":"10.1016\/j.heliyon.2023.e22307_bib76","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.exer.2018.09.023","article-title":"The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE","volume":"181","author":"Jun","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93899-x","article-title":"Long-term outcomes of ranibizumab vs. aflibercept for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy","volume":"11","author":"Jin","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heliyon.2023.e22307_bib78","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41467-017-00140-3","article-title":"Genome editing abrogates angiogenesis in vivo","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.heliyon.2023.e22307_bib79","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00018-019-03422-9","article-title":"The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective","volume":"77","author":"Mammadzada","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib80","article-title":"LncRNA-MALAT1 promotes neovascularization in diabetic retinopathy through regulating miR-125b\/VE-cadherin axis","volume":"39","author":"Liu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.heliyon.2023.e22307_bib81","doi-asserted-by":"crossref","first-page":"49688","DOI":"10.18632\/oncotarget.10434","article-title":"Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.heliyon.2023.e22307_bib82","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/CIRCRESAHA.116.305510","article-title":"lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA","volume":"116","author":"Yan","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.heliyon.2023.e22307_bib86","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200887R","article-title":"Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2\/miR-134-5p\/NF-kappaB signaling pathway","volume":"36","author":"Du","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.heliyon.2023.e22307_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15051454","article-title":"Long non-coding RNAs and proliferative retinal diseases","volume":"15","author":"Sharma","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.heliyon.2023.e22307_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032636","article-title":"Non-coding RNAs regulating mitochondrial functions and the oxidative stress response as Putative targets against age-related macular degeneration (AMD)","volume":"24","author":"Hyttinen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.heliyon.2023.e22307_bib85","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/08820538.2022.2152706","article-title":"Molecular Mediators and regulators of retinal angiogenesis","volume":"38","author":"Vishwakarma","year":"2023","journal-title":"Semin. Ophthalmol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023095154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844023095154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:36:24Z","timestamp":1791293784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844023095154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":86,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2405844023095154"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22307","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles and mechanisms of long non-coding RNAs in age-related macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e22307"}}