{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:48:42Z","timestamp":1793051322873,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20234Y0162"],"award-info":[{"award-number":["20234Y0162"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240228"],"award-info":[{"award-number":["202240228"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973849-H2709"],"award-info":[{"award-number":["81973849-H2709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274528"],"award-info":[{"award-number":["82274528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.heliyon.2024.e25762","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T12:36:24Z","timestamp":1707482184000},"page":"e25762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Extracellular vesicles secreted by bone marrow stem cells mediate angiogenesis for the treatment of diabetic ulcers: A systematic review and meta-analysis of preclinical studies"],"prefix":"10.1016","volume":"10","author":[{"given":"Yuqing","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3282-1104","authenticated-orcid":false,"given":"Guobin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong","year":"2023","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.heliyon.2024.e25762_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/01.ASW.0000791876.10485.d4","article-title":"A comprehensive review of the pathogenesis, diagnosis, and management of diabetic foot infections","volume":"34","author":"Mponponsuo","year":"2021","journal-title":"Adv. Skin Wound Care"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e25762_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for treatment of infected diabetic foot ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.asjsur.2021.07.047","article-title":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis","volume":"45","author":"Zhang","year":"2022","journal-title":"Asian J. Surg."},{"issue":"11","key":"10.1016\/j.heliyon.2024.e25762_bib5","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1464-5491.2004.01358.x","article-title":"New and experimental approaches to treatment of diabetic foot ulcers: a comprehensive review of emerging treatment strategies","volume":"21","author":"Eldor","year":"2004","journal-title":"Diabet. Med."},{"key":"10.1016\/j.heliyon.2024.e25762_bib6","first-page":"37","article-title":"New therapies for the treatment of diabetic foot ulcers: updated review of clinical trials","volume":"37","author":"Stratman","year":"2020","journal-title":"Surg. Technol. Int."},{"issue":"Suppl 1","key":"10.1016\/j.heliyon.2024.e25762_bib7","doi-asserted-by":"crossref","first-page":"e3266","DOI":"10.1002\/dmrr.3266","article-title":"Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update)","volume":"36","author":"Schaper","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.heliyon.2024.e25762_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154824","article-title":"A systematic review of natural products for skin applications: targeting inflammation, wound healing, and photo-aging","volume":"115","author":"Fernandes","year":"2023","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.heliyon.2024.e25762_bib9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jid.2023.02.019","article-title":"Therapeutic application of cell secretomes in cutaneous wound healing","volume":"143","author":"Bormann","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.heliyon.2024.e25762_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/s13770-023-00542-z","article-title":"Exosomal microRNAs from mesenchymal stem cells: novel therapeutic effect in wound healing","author":"Ju","year":"2023","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.heliyon.2024.e25762_bib11","article-title":"Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds","volume":"14","author":"Yu","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e25762_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrc3217","article-title":"Epithelial stem cells, wound healing and cancer","volume":"12","author":"Arwert","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e25762_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11041003","article-title":"Acellular biomaterials associated with autologous bone marrow-derived mononuclear stem cells improve wound healing through paracrine effects","volume":"11","author":"de Souza","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13287-023-03345-0","article-title":"Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing","volume":"14","author":"Zhou","year":"2023","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13287-018-0791-7","article-title":"Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine","volume":"9","author":"Keshtkar","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.heliyon.2024.e25762_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121605","article-title":"Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e25762_bib17","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular vesicles in immunomodulation and tumor progression","volume":"22","author":"Marar","year":"2021","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.heliyon.2024.e25762_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12015-020-10082-x","article-title":"Preclinical experimental applications of miRNA loaded BMSC extracellular vesicles","volume":"17","author":"Cetin","year":"2021","journal-title":"Stem Cell Rev Rep"},{"issue":"6478","key":"10.1016\/j.heliyon.2024.e25762_bib19","first-page":"367","article-title":"The biology, function, and biomedical applications of exosomes","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13287-021-02317-6","article-title":"Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1beta-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s13287-020-01707-6","article-title":"Extracellular vesicle-encapsulated miR-22-3p from bone marrow mesenchymal stem cell promotes osteogenic differentiation via FTO inhibition","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"21","key":"10.1016\/j.heliyon.2024.e25762_bib22","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1182\/bloodadvances.2019000403","article-title":"Induction of multiple myeloma bone marrow stromal cell apoptosis by inhibiting extracellular vesicle miR-10a secretion","volume":"3","author":"Umezu","year":"2019","journal-title":"Blood Adv"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535745","article-title":"Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey","volume":"7","author":"Soekmadji","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.heliyon.2024.e25762_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.heliyon.2024.e25762_bib26","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.omtn.2019.11.034","article-title":"The MSC-derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via MicroRNA-152-3p","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e25762_bib27","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/acs.molpharmaceut.1c00669","article-title":"Mesenchymal stem cell-derived exosomes loaded with miR-155 inhibitor ameliorate diabetic wound healing","volume":"19","author":"Gondaliya","year":"2022","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.heliyon.2024.e25762_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15283\/ijsc21067","article-title":"Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells","volume":"15","author":"Wang","year":"2022","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.heliyon.2024.e25762_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112613","article-title":"A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing","volume":"133","author":"Geng","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.heliyon.2024.e25762_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109126","article-title":"Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing","volume":"183","author":"Han","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s13287-020-01824-2","article-title":"Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT\/eNOS pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.heliyon.2024.e25762_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002070","article-title":"HOTAIR-loaded mesenchymal stem\/stromal cell extracellular vesicles enhance angiogenesis and wound healing","volume":"11","author":"Born","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.heliyon.2024.e25762_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9742765","article-title":"Exosomes derived from human bone marrow mesenchymal stem cells stimulated by deferoxamine accelerate cutaneous wound healing by promoting angiogenesis","volume":"2019","author":"Ding","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e25762_bib34","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1039\/D2TB02371G","article-title":"In situ photo-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing","volume":"11","author":"Wang","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13287-020-01756-x","article-title":"Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN\/AKT pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"8","key":"10.1016\/j.heliyon.2024.e25762_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083851","article-title":"Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and correlation to their cargoes","volume":"22","author":"Pomatto","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13287-021-02400-y","article-title":"BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs","volume":"12","author":"Jin","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.heliyon.2024.e25762_bib38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00441-007-0417-3","article-title":"Treatment of diabetic wounds with fetal murine mesenchymal stromal cells enhances wound closure","volume":"329","author":"Badillo","year":"2007","journal-title":"Cell Tissue Res."},{"issue":"9","key":"10.1016\/j.heliyon.2024.e25762_bib39","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1359\/jbmr.1999.14.9.1522","article-title":"Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2\/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation","volume":"14","author":"Gori","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.heliyon.2024.e25762_bib40","first-page":"42","article-title":"Stromal stem cells: marrow-derived osteogenic precursors","volume":"136","author":"Owen","year":"1988","journal-title":"Ciba Found. Symp."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e25762_bib41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.heliyon.2024.e25762_bib42","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.reth.2022.01.006","article-title":"Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury","volume":"19","author":"Imam","year":"2022","journal-title":"Regen Ther"},{"issue":"3","key":"10.1016\/j.heliyon.2024.e25762_bib43","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/acsbiomaterials.9b01550","article-title":"Macrophage polarization mediated by chitooligosaccharide (COS) and associated osteogenic and angiogenic activities","volume":"6","author":"Huang","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.heliyon.2024.e25762_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.110201","article-title":"Bone marrow-derived mesenchymal stem cells: a promising therapeutic option for the treatment of diabetic foot ulcers","volume":"195","author":"Dama","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.heliyon.2024.e25762_bib45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.reth.2020.11.003","article-title":"Stem cell therapy for osteonecrosis of femoral head: opportunities and challenges","volume":"15","author":"Xu","year":"2020","journal-title":"Regen Ther"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41413-023-00289-2","article-title":"HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation","volume":"11","author":"Li","year":"2023","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib47","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12951-023-02169-7","article-title":"Superior TRAIL gene expression and cancer cell apoptosis mediated by highly branched-linear poly(beta-amino ester)s","volume":"21","author":"Zhao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.heliyon.2024.e25762_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107983","article-title":"Boosting extracellular vesicle secretion","volume":"59","author":"Debbi","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.heliyon.2024.e25762_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100849","article-title":"Extracellular vesicle therapy for retinal diseases","volume":"79","author":"Mead","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"7","key":"10.1016\/j.heliyon.2024.e25762_bib50","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.heliyon.2024.e25762_bib51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/5584_2020_599","article-title":"Extracellular vesicle therapeutics in regenerative medicine","volume":"1312","author":"Imafuku","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e25762_bib52","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s12015-021-10164-4","article-title":"MSC-derived extracellular vesicles to heal diabetic wounds: a systematic review and meta-analysis of preclinical animal studies","volume":"18","author":"Bailey","year":"2022","journal-title":"Stem Cell Rev Rep"},{"issue":"8","key":"10.1016\/j.heliyon.2024.e25762_bib53","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.7150\/thno.44115","article-title":"Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2","volume":"10","author":"Luo","year":"2020","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e25762_bib54","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jbm.a.37105","article-title":"Skin wound healing assisted by angiogenic targeted tissue engineering: a comprehensive review of bioengineered approaches","volume":"109","author":"Nour","year":"2021","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10456-020-09748-4","article-title":"BMP6\/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF","volume":"24","author":"Pulkkinen","year":"2021","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e25762_bib56","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10456-018-9634-5","article-title":"PDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation","volume":"21","author":"Gianni-Barrera","year":"2018","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jtv.2020.12.002","article-title":"Chitosan and gelatin biopolymer supplemented with mesenchymal stem cells (Velgraft(R)) enhanced wound healing in goats (Capra hircus): involvement of VEGF, TGF and CD31","volume":"30","author":"Shukla","year":"2021","journal-title":"J. Tissue Viability"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e25762_bib58","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12951-021-00894-5","article-title":"Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis","volume":"19","author":"Hu","year":"2021","journal-title":"J. Nanobiotechnol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024017936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024017936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:13:17Z","timestamp":1790712797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844024017936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2405844024017936"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e25762","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles secreted by bone marrow stem cells mediate angiogenesis for the treatment of diabetic ulcers: A systematic review and meta-analysis of preclinical studies","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e25762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e25762"}}