{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:15:53Z","timestamp":1789748153611,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["H2020-JTI-IMI2-2017-13"],"award-info":[{"award-number":["H2020-JTI-IMI2-2017-13"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["IMI2-2017-13-02"],"award-info":[{"award-number":["IMI2-2017-13-02"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["H2020-EU.3.1.7"],"award-info":[{"award-number":["H2020-EU.3.1.7"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010676","name":"Horizon 2020 Societal Challenges","doi-asserted-by":"publisher","award":["821511"],"award-info":[{"award-number":["821511"]}],"id":[{"id":"10.13039\/100010676","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.heliyon.2024.e31723","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T03:11:29Z","timestamp":1719198689000},"page":"e31723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers \u2013 A qualitative expert interview study in dermatology research"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-4603","authenticated-orcid":false,"given":"Nora","family":"Hangel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Buyx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Fritzsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.heliyon.2024.e31723_bib1","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis A review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.heliyon.2024.e31723_bib2","article-title":"Prevalence and incidence of atopic dermatitis: a systematic review","volume":"100","author":"Bylund","year":"2020","journal-title":"Acta DV Advances in dermatology and venereology"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e31723_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/jamadermatol.2016.5538","article-title":"Global skin disease morbidity and mortality: an update from the global burden of disease study 2013","volume":"153","author":"Karimkhani","year":"2017","journal-title":"JAMA Dermatol"},{"issue":"suppl_2","key":"10.1016\/j.heliyon.2024.e31723_bib4","doi-asserted-by":"crossref","first-page":"ii18","DOI":"10.1136\/ard.2004.033217","article-title":"Psoriasis: epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.heliyon.2024.e31723_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/children6100108","article-title":"Pathophysiology of atopic dermatitis and psoriasis: implications for management in children","volume":"6","author":"Chovatiya","year":"2019","journal-title":"Children"},{"key":"10.1016\/j.heliyon.2024.e31723_bib6","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.3389\/fimmu.2018.02727","article-title":"Leveraging multilayered \"omics\" data for atopic dermatitis: a road map to precision medicine","volume":"9","author":"Ghosh","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.heliyon.2024.e31723_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/gim.2016.183","article-title":"The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues","volume":"19","author":"Sankar","year":"2017","journal-title":"Genet. Med."},{"key":"10.1016\/j.heliyon.2024.e31723_bib8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2147\/CCID.S227896","article-title":"Omics-driven biomarkers of psoriasis: recent insights, current challenges, and future prospects","volume":"13","author":"Aydin","year":"2020","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e31723_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5114\/ada.2018.77661","article-title":"Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future","volume":"35","author":"Osmola-Ma\u0144kowska","year":"2018","journal-title":"Post\u0119py Dermatologii i Alergologii"},{"issue":"3","key":"10.1016\/j.heliyon.2024.e31723_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/jcm4030479","article-title":"New developments in biomarkers for atopic dermatitis","volume":"4","author":"Thijs","year":"2015","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.heliyon.2024.e31723_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-020-00958-9","article-title":"Aiming for cure and preventive initiatives in psoriatic disease: building synergy at NPF, GRAPPA, and PPACMAN","volume":"22","author":"Bell","year":"2020","journal-title":"Curr. Rheumatol. Rep."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e31723_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40656-019-0266-x","article-title":"From parts to mechanism: research heuristics for addressing heterogeneity, Hist","volume":"41","author":"Bechtel","year":"2019","journal-title":"Philos. Life Sci."},{"issue":"5","key":"10.1016\/j.heliyon.2024.e31723_bib31","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/bjd.20587","article-title":"The BIOMarkers in Atopic Dermatitis and Psoriasis (BIOMAP) glossary: developing a lingua franca to facilitate data harmonization and cross\u2010cohort analyses","volume":"185","author":"Broderick","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e31723_bib13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/bjd.21627","article-title":"Biomarkers of disease progression in people with psoriasis: a scoping review","volume":"187","author":"Ramessur","year":"2022","journal-title":"Br. J. Dermatol."},{"issue":"10","key":"10.1016\/j.heliyon.2024.e31723_bib32","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/exd.14446","article-title":"The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases","volume":"30","author":"Alenius","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.heliyon.2024.e31723_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.nbt.2016.06.1458","article-title":"Mapping ethical and social aspects of cancer biomarkers","volume":"33","author":"Blanchard","year":"2016","journal-title":"N. Biotech."},{"issue":"8","key":"10.1016\/j.heliyon.2024.e31723_bib33","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/jdv.18128","article-title":"Mapping ethical and social aspects of biomarker research and its application in atopic dermatitis and psoriasis: a systematic review of reason","volume":"36","author":"Fritzsche","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e31723_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10916-020-01702-7","article-title":"My data, my choice? - German patient organizations' attitudes towards big data-driven approaches in personalized medicine. An empirical-ethical study","volume":"45","author":"Rauter","year":"2021","journal-title":"J. Med. Syst."},{"key":"10.1016\/j.heliyon.2024.e31723_bib16","article-title":"\"Asset exchange\"-interactions between patient groups and pharmaceutical industry: Australian qualitative study","volume":"367","author":"Parker","year":"2019","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e31723_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/09581596.2022.2035319","article-title":"Chronicity in\/and cancer: a qualitative interview study of health professionals, patients, and family carers","volume":"32","author":"Kirby","year":"2022","journal-title":"Crit. Publ. Health"},{"key":"10.1016\/j.heliyon.2024.e31723_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2021.113760","article-title":"Actionable data for precision oncology: framing trustworthy evidence for exploratory research and clinical diagnostics","volume":"272","author":"Tempini","year":"2021","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.heliyon.2024.e31723_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ssmqr.2022.100096","article-title":"Living (well) with cancer in the precision era","volume":"2","author":"Broom","year":"2022","journal-title":"SSM - Qualitative Research in Health"},{"key":"10.1016\/j.heliyon.2024.e31723_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2022.115608","article-title":"Entanglements and imagined futures: the subject(s) of precision in oncology","volume":"317","author":"Flore","year":"2023","journal-title":"Soc. Sci. Med."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e31723_bib21","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/jep.13789","article-title":"Mapping uncertainty in precision medicine: a systematic scoping review","volume":"29","author":"Lohse","year":"2023","journal-title":"J. Eval. Clin. Pract."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e31723_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/13645579.2020.1766777","article-title":"\u2018The problem-centred expert interview\u2019. Combining qualitative interviewing approaches for investigating implicit expert knowledge","volume":"24","author":"D\u00f6ringer","year":"2020","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"10.1016\/j.heliyon.2024.e31723_bib23","series-title":"Introducing Qualitative Methods","first-page":"388","article-title":"Constructing grounded theory","author":"Charmaz","year":"2014"},{"key":"10.1016\/j.heliyon.2024.e31723_bib24","series-title":"Qualitative Research from Start to Finish","first-page":"386","author":"Yin","year":"2016"},{"key":"10.1016\/j.heliyon.2024.e31723_bib25","series-title":"Social Research Methods","author":"Bryman","year":"2016"},{"issue":"6","key":"10.1016\/j.heliyon.2024.e31723_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","article-title":"Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups","volume":"19","author":"Tong","year":"2007","journal-title":"Int. J. Qual. Health Care"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e31723_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/bjd\/ljae080","article-title":"Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective","volume":"191","author":"Ramessur","year":"2024","journal-title":"Br. J. Dermatol."},{"issue":"9","key":"10.1016\/j.heliyon.2024.e31723_bib34","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/jdv.18178","article-title":"Requirements and expectations of high\u2010quality biomarkers for atopic dermatitis and psoriasis in 2021\u2014a two\u2010round Delphi survey among international experts","volume":"36","author":"Ziehfreund","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"136","key":"10.1016\/j.heliyon.2024.e31723_bib27","article-title":"Toward precision healthcare: context and mathematical challenges","volume":"8","author":"Colijn","year":"2017","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e31723_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/oem.60.4.235","article-title":"The right treatment to the right patient at the right time","volume":"60","author":"Haldorsen","year":"2003","journal-title":"Occup. Environ. Med."},{"issue":"5","key":"10.1016\/j.heliyon.2024.e31723_bib29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/scipol\/scaa013","article-title":"The meaning and enactment of openness in Personalised and Precision Medicine","volume":"47","author":"Prainsack","year":"2020","journal-title":"Sci. Publ. Pol."},{"issue":"3\u20134","key":"10.1016\/j.heliyon.2024.e31723_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000513753","article-title":"Stakeholders' interest and attitudes toward genomic medicine and pharmacogenomics implementation in the United Arab Emirates: a qualitative study","volume":"24","author":"Rahma","year":"2021","journal-title":"Public Health Genomics"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024077545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024077545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:40:15Z","timestamp":1778884815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844024077545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":35,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2405844024077545"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e31723","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers \u2013 A qualitative expert interview study in dermatology research","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e31723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e31723"}}