{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:52:33Z","timestamp":1792497153061,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012594","name":"Scientific Research Foundation of Shaanxi Provincial Key Laboratory","doi-asserted-by":"publisher","award":["2020SF-179"],"award-info":[{"award-number":["2020SF-179"]}],"id":[{"id":"10.13039\/501100012594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372530"],"award-info":[{"award-number":["82372530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072182"],"award-info":[{"award-number":["82072182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.heliyon.2024.e33802","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T03:01:58Z","timestamp":1719630118000},"page":"e33802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Isorhamnetin inhibits hypertrophic scar formation through TGF-\u03b21\/Smad and TGF-\u03b21\/CREB3L1 signaling pathways"],"prefix":"10.1016","volume":"10","author":[{"given":"Junzheng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-5201","authenticated-orcid":false,"given":"Baoqiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2024.e33802_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s41038-018-0129-9","article-title":"Chinese expert consensus on clinical prevention and treatment of scar","volume":"6","author":"Lv","year":"2018","journal-title":"Burns Trauma"},{"issue":"8","key":"10.1016\/j.heliyon.2024.e33802_bib2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/ced.15147","article-title":"Surgical considerations in skin of colour: minimizing pathological scars","volume":"47","author":"Obi","year":"2022","journal-title":"Clin. Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.heliyon.2024.e33802_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40257-022-00744-6","article-title":"Hypertrophic scars and keloids: advances in treatment and review of established therapies","volume":"24","author":"Frech","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.heliyon.2024.e33802_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mad.2017.11.004","article-title":"The role of TGF\u03b2 in wound healing pathologies","volume":"172","author":"Kiritsi","year":"2018","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-022-01569-x","article-title":"Targeting TGF-\u03b2 signal transduction for fibrosis and cancer therapy","volume":"21","author":"Peng","year":"2022","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.heliyon.2024.e33802_bib6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGF\u03b2 signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcp.30529","article-title":"TGF-\u03b2 signaling: a recap of SMAD-independent and SMAD-dependent pathways","volume":"237","author":"Aashaq","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.heliyon.2024.e33802_bib8","article-title":"Sustained induction of collagen synthesis by TGF-\u03b2 requires regulated intramembrane proteolysis of CREB3L1","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2024.e33802_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110301","article-title":"Isorhamnetin: a review of pharmacological effects","volume":"128","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.heliyon.2024.e33802_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1309178","article-title":"Isorhamnetin: what is the in vitro evidence for its antitumor potential and beyond?","volume":"15","author":"Lei","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heliyon.2024.e33802_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6175091","article-title":"Isorhamnetin inhibits liver fibrosis by reducing autophagy and inhibiting extracellular matrix formation via the TGF-\u03b21\/smad3 and TGF-\u03b21\/p38 MAPK pathways","author":"Liu","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.heliyon.2024.e33802_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2016.04.042","article-title":"Isorhamnetin attenuates liver fibrosis by inhibiting TGF-\u03b2\/Smad signaling and relieving oxidative stress","volume":"783","author":"Yang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.heliyon.2024.e33802_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110287","article-title":"Current potential therapeutic strategies targeting the TGF-\u03b2\/Smad signaling pathway to attenuate keloid and hypertrophic scar formation","volume":"129","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.heliyon.2024.e33802_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119483","article-title":"Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-\u03b2\/Smad signal pathway","volume":"277","author":"Li","year":"2021","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e33802_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24984","article-title":"CLC-3 regulates TGF-\u03b2\/smad signaling pathway to inhibit the process of fibrosis in hypertrophic scar","volume":"10","author":"Liang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.heliyon.2024.e33802_bib16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.biopha.2018.06.176","article-title":"Usnic acid inhibits hypertrophic scarring in a rabbit ear model by sup-pressing scar tissue angiogenesis","volume":"108","author":"Song","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.heliyon.2024.e33802_bib17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fphar.2020.00602","article-title":"Tetramethylpyrazine induces apoptosis and inhibits proliferation of hypertrophic scar-derived fibroblasts via inhibiting the phosphorylation of AKT","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.heliyon.2024.e33802_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2184.2003.00267.x","article-title":"Cell cycle and apoptosis","volume":"36","author":"Vermeulen","year":"2003","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib19","doi-asserted-by":"crossref","first-page":"79e","DOI":"10.1097\/PRS.0000000000008667","article-title":"The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago","volume":"149","author":"Ogawa","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"issue":"8","key":"10.1016\/j.heliyon.2024.e33802_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.6061\/clinics\/2014(08)11","article-title":"Update on hypertrophic scar treatment","volume":"69","author":"Rabello","year":"2014","journal-title":"Clinics"},{"key":"10.1016\/j.heliyon.2024.e33802_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.matbio.2017.12.003","article-title":"Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts","volume":"67","author":"Avery","year":"2018","journal-title":"Matrix Biol."},{"issue":"6","key":"10.1016\/j.heliyon.2024.e33802_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"Tgf-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022137","article-title":"Signaling cross talk between tgf-\u03b2\/smad and other signaling pathways","volume":"9","author":"Luo","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7150\/ijms.90189","article-title":"The regulatory network of creb3l1 and its roles in physiological and pathological conditions","volume":"21","author":"Zhao","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.heliyon.2024.e33802_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fcell.2019.00123","article-title":"Creb3 transcription factors: er-golgi stress transducers as hubs for cellular homeostasis","volume":"7","author":"Sampieri","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13023-020-01361-4","article-title":"Mutations in col1a1\/a2 and creb3l1 are associated with oligodontia in osteogenesis imperfecta","volume":"15","author":"Andersson","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.heliyon.2024.e33802_bib27","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.molcel.2016.06.032","article-title":"Inverting the topology of a transmembrane protein by regulating the translocation of the first transmembrane helix","volume":"63","author":"Chen","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.heliyon.2024.e33802_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/febs.17052","article-title":"Creb3l1\/oasis: cell cycle regulator and tumor suppressor","author":"Saito","year":"2024","journal-title":"FEBS J."},{"key":"10.1016\/j.heliyon.2024.e33802_bib29","article-title":"Single-cell and bulk transcriptome data integration reveals dysfunctional cell types and aberrantly expressed genes in hypertrophic scar","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.heliyon.2024.e33802_bib30","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s42003-022-03709-x","article-title":"Upregulation of oasis\/creb3l1 in podocytes contributes to the disturbance of kidney homeostasis","volume":"5","author":"Miyake","year":"2022","journal-title":"Commun. Biol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024098335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024098335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:59:46Z","timestamp":1778885986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844024098335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2405844024098335"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e33802","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isorhamnetin inhibits hypertrophic scar formation through TGF-\u03b21\/Smad and TGF-\u03b21\/CREB3L1 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e33802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e33802"}}