{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T21:18:05Z","timestamp":1794691085918,"version":"4.9.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017026","name":"Spastic Paraplegia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/37\/B\/NZ2\/03268"],"award-info":[{"award-number":["2020\/37\/B\/NZ2\/03268"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009362","name":"South London and Maudsley NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","award":["Jones\/Oct15\/958-799"],"award-info":[{"award-number":["Jones\/Oct15\/958-799"]}],"id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019418","name":"NIHR Maudsley Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","award":["222811\/Z\/21\/Z"],"award-info":[{"award-number":["222811\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R024804\/1"],"award-info":[{"award-number":["MR\/R024804\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L501529\/1"],"award-info":[{"award-number":["MR\/L501529\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009360","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019524","name":"Yayasan Sime Darby","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","award":["Al Khleifat\/Oct21\/975-799"],"award-info":[{"award-number":["Al Khleifat\/Oct21\/975-799"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG055654"],"award-info":[{"award-number":["RF1AG055654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N510129\/1"],"award-info":[{"award-number":["EP\/N510129\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001461","name":"Ministry of National Development - Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012338","name":"Alan Turing Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.heliyon.2024.e35342","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T13:47:05Z","timestamp":1722260825000},"page":"e35342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-3281","authenticated-orcid":false,"given":"Oliver","family":"Pain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al Khleifat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzmitry","family":"Hramyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajer","family":"Karoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u0119drzej","family":"Kubica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Llewellyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M.","family":"Ranson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Iacoangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Al-Chalabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10107","key":"10.1016\/j.heliyon.2024.e35342_bib1","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"Van Es","year":"2017","journal-title":"The Lancet"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1016\/j.heliyon.2024.e35342_bib3","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s00415-006-0195-y","article-title":"Amyotrophic lateral sclerosis in an urban setting","volume":"253","author":"Johnston","year":"2006","journal-title":"J Neurol"},{"issue":"7\u20138","key":"10.1016\/j.heliyon.2024.e35342_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/21678421.2020.1779298","article-title":"Focus on the heterogeneity of amyotrophic lateral sclerosis","volume":"21","author":"Bendotti","year":"2020","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.heliyon.2024.e35342_bib5","first-page":"1","article-title":"Sodium phenylbutyrate and Ursodoxicoltaurine: first approval","author":"Heo","year":"2022","journal-title":"CNS Drugs"},{"issue":"3","key":"10.1016\/j.heliyon.2024.e35342_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001447.pub3","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","author":"Miller","year":"2012","journal-title":"Cochrane database of systematic reviews"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib7","first-page":"25","article-title":"Edaravone (Radicava): a novel neuroprotective agent for the treatment of amyotrophic lateral sclerosis","volume":"43","author":"Cruz","year":"2018","journal-title":"Pharmacy and Therapeutics"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrneurol.2016.182","article-title":"Gene discovery in amyotrophic lateral sclerosis: implications for clinical management","volume":"13","author":"Al-Chalabi","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e35342_bib10","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nn.4000","article-title":"Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia","volume":"18","author":"Freischmidt","year":"2015","journal-title":"Nat Neurosci"},{"issue":"12","key":"10.1016\/j.heliyon.2024.e35342_bib11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1136\/jnnp.2010.207464","article-title":"An estimate of amyotrophic lateral sclerosis heritability using twin data","volume":"81","author":"Al-Chalabi","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"10.1016\/j.heliyon.2024.e35342_bib12","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/jamaneurol.2014.4049","article-title":"Heritability of amyotrophic lateral sclerosis: insights from disparate numbers","volume":"72","author":"McLaughlin","year":"2015","journal-title":"JAMA Neurol"},{"issue":"12","key":"10.1016\/j.heliyon.2024.e35342_bib13","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1093\/brain\/awac279","article-title":"The impact of age on genetic testing decisions in amyotrophic lateral sclerosis","volume":"145","author":"Mehta","year":"2022","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.heliyon.2024.e35342_bib14","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/jamaneurol.2014.1184","article-title":"Genome-wide analysis of the heritability of amyotrophic lateral sclerosis","volume":"71","author":"Keller","year":"2014","journal-title":"JAMA Neurol"},{"issue":"12","key":"10.1016\/j.heliyon.2024.e35342_bib15","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41588-021-00973-1","article-title":"Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology","volume":"53","author":"Van Rheenen","year":"2021","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.heliyon.2024.e35342_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e35342_bib17","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41588-018-0092-1","article-title":"Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights","volume":"50","author":"Gusev","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.heliyon.2024.e35342_bib18","article-title":"Delineating the genetic component of gene expression in major depression","author":"Dall'Aglio","year":"2020","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41588-020-00773-z","article-title":"Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis","volume":"53","author":"Wingo","year":"2021","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e35342_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41588-019-0364-4","article-title":"Gene expression imputation across multiple brain regions provides insights into schizophrenia risk","volume":"51","author":"Huckins","year":"2019","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e35342_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"14","key":"10.1016\/j.heliyon.2024.e35342_bib22","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1093\/bioinformatics\/bty982","article-title":"Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes","volume":"35","author":"Gaspar","year":"2018","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.heliyon.2024.e35342_bib23","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/nn.4618","article-title":"Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry","volume":"20","author":"So","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.heliyon.2024.e35342_bib24","first-page":"1","article-title":"Tutorial: a guide to performing polygenic risk score analyses","author":"Choi","year":"2020","journal-title":"Nat Protoc"},{"issue":"8","key":"10.1016\/j.heliyon.2024.e35342_bib25","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1038\/s41380-023-02200-1","article-title":"Transcriptomic risk scores for attention deficit\/hyperactivity disorder","volume":"28","author":"Cabana-Dom\u00ednguez","year":"2023","journal-title":"Mol Psychiatry"},{"issue":"10","key":"10.1016\/j.heliyon.2024.e35342_bib26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/ng.3936","article-title":"Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease","volume":"49","author":"Marigorta","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.heliyon.2024.e35342_bib27","author":"King\u2019s College"},{"key":"10.1016\/j.heliyon.2024.e35342_bib28","article-title":"A simple new approach to variable selection in regression, with application to genetic fine-mapping","author":"Wang","year":"2020","journal-title":"BioRxiv"},{"issue":"6235","key":"10.1016\/j.heliyon.2024.e35342_bib29","first-page":"648","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"Consortium","year":"2015","journal-title":"Science (1979)"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-93742-3","article-title":"A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex","volume":"11","author":"Jones","year":"2021","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e35342_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab236","article-title":"SCFD1 expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed","volume":"3","author":"Iacoangeli","year":"2021","journal-title":"Brain Commun"},{"issue":"3","key":"10.1016\/j.heliyon.2024.e35342_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ajhg.2022.01.005","article-title":"Leveraging gene co-regulation to identify gene sets enriched for disease heritability","volume":"109","author":"Siewert-Rocks","year":"2022","journal-title":"The American Journal of Human Genetics"},{"issue":"4","key":"10.1016\/j.heliyon.2024.e35342_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biopsych.2019.04.034","article-title":"Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics","volume":"86","author":"Pain","year":"2019","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.heliyon.2024.e35342_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198874","article-title":"Whole blood transcriptome analysis in amyotrophic lateral sclerosis: a biomarker study","volume":"13","author":"Van Rheenen","year":"2018","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.heliyon.2024.e35342_bib35","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.heliyon.2024.e35342_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddab053","article-title":"Imputed gene expression risk scores: a functionally informed component of polygenic risk","author":"Pain","year":"2021","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib37","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1038\/s41467-023-41033-y","article-title":"Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113636","article-title":"TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis","volume":"43","author":"Guise","year":"2024","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/physiolgenomics.00087.2001","article-title":"Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter","volume":"16","author":"Dangond","year":"2004","journal-title":"Physiol Genomics"},{"issue":"9","key":"10.1016\/j.heliyon.2024.e35342_bib40","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1073\/pnas.1616332114","article-title":"TMEM175 deficiency impairs lysosomal and mitochondrial function and increases \u03b1-synuclein aggregation","volume":"114","author":"Jinn","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib41","article-title":"The effectiveness of nonsteroidal anti-inflammatory drugs and acetaminophen in reduce the risk of amyotrophic lateral sclerosis? A meta-analysis","volume":"10","author":"Chang","year":"2020","journal-title":"Sci Rep"},{"issue":"13","key":"10.1016\/j.heliyon.2024.e35342_bib42","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1517\/14656566.7.13.1825","article-title":"Sertindole: efficacy and safety in schizophrenia","volume":"7","author":"Lindstr\u00f6m","year":"2006","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.phrs.2011.12.001","article-title":"The anabolic\/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis","volume":"65","author":"Galbiati","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.heliyon.2024.e35342_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.brainres.2016.12.029","article-title":"Effect of physical exercise and anabolic steroid treatment on spinal motoneurons and surrounding glia of wild-type and ALS mice","volume":"1657","author":"Kassa","year":"2017","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12916-024-03314-1","article-title":"TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro","volume":"22","author":"Duan","year":"2024","journal-title":"BMC Med"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-022-02212-0","article-title":"Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study","volume":"17","author":"Xia","year":"2022","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"10.1016\/j.heliyon.2024.e35342_bib47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/jamaneurol.2020.4300","article-title":"Effect of ezogabine on cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis: a randomized clinical trial","volume":"78","author":"Wainger","year":"2021","journal-title":"JAMA Neurol"},{"issue":"10","key":"10.1016\/j.heliyon.2024.e35342_bib48","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1194\/jlr.RA119000119","article-title":"SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation [S]","volume":"60","author":"San\u00e9","year":"2019","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s12035-023-03587-2","article-title":"Abnormal brain protein abundance and cross-tissue mRNA expression in amyotrophic lateral sclerosis","volume":"61","author":"Ma","year":"2024","journal-title":"Mol Neurobiol"},{"issue":"8","key":"10.1016\/j.heliyon.2024.e35342_bib50","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1007\/s00415-023-11757-4","article-title":"Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data","volume":"270","author":"Gu","year":"2023","journal-title":"J Neurol"},{"key":"10.1016\/j.heliyon.2024.e35342_bib51","first-page":"1","article-title":"Quantifying genetic effects on disease mediated by assayed gene expression levels","author":"Yao","year":"2020","journal-title":"Nat Genet"},{"issue":"7571","key":"10.1016\/j.heliyon.2024.e35342_bib52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.heliyon.2024.e35342_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet."},{"issue":"5","key":"10.1016\/j.heliyon.2024.e35342_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.heliyon.2024.e35342_bib55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12859-018-2057-x","article-title":"lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals","volume":"19","author":"Ziyatdinov","year":"2018","journal-title":"BMC Bioinformatics"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024113734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844024113734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:02:56Z","timestamp":1784066576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844024113734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":55,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2405844024113734"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e35342","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.01.18.23284589","asserted-by":"object"}]},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2024.e35342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e35342"}}