{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:43Z","timestamp":1787841343670,"version":"build-2784847793"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                    <jats:p>This study aims to examine the possible association of Epstein-Barr virus (EBV) in Classical Hodgkin lymphoma (cHL) and to shed light on the epidemiology of Hodgkin lymphoma (HL) in Jordan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS:<\/jats:title>\n                    <jats:p>We examined 100 consecutive cases of HL for the presence of EBV in tumor cells by immunohistochemistry for latent membrane protein-1 (LMP-1). We collected patient data on age, sex and histologic subtype. We reviewed the pathological findings in each case and confirmed diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Nodular lymphocyte predominant HL was diagnosed in 6% of the cases and these were negative for EBV LMP-1. Of the 94 cases of cHL, 65% were males, the most common subtype was nodular sclerosis (NS), representing 70% of the cases, and 45.7% of cHL (43% of all HL) cases were positive for EBV LMP-1. The positive cases were significantly related to age: \u226415 years and &gt;51 years (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      : 0.009 and 0.014 respectively), male gender (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      : 0.03) and mixed cellularity (MC) subtype (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      : &lt;0.0001). In line with other developing countries, there also appears to be a trend towards a decreasing association of EBV with cHL and a subtype switch from MC to NS in Jordan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The epidemiology of HL in Jordan and some developing countries is approaching that of developed countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2013.12.002","type":"journal-article","created":{"date-parts":[[2014,1,25]],"date-time":"2014-01-25T22:15:14Z","timestamp":1390688114000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Epstein-Barr virus and Hodgkin lymphoma in Jordan"],"prefix":"10.4103","volume":"7","author":[{"given":"Maher A","family":"Sughayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam A","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana M","family":"Al-Yousef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"El-Khateeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanoods","family":"Abu-Rass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"4","key":"10.1016\/j.hemonc.2013.12.002_b0005","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T","article-title":"Epstein\u2013Barr virus-associated Hodgkin\u2019s disease: epidemiologic characteristics in international data","volume":"70","author":"Glaser","year":"1997","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.hemonc.2013.12.002_b0010","first-page":"e2009013","article-title":"EBV in Hodgkin Lymphoma","volume":"1","author":"Massini","year":"2009","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"5","key":"10.1016\/j.hemonc.2013.12.002_b0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/mp.53.5.262","article-title":"Hodgkin\u2019s disease and the Epstein\u2013Barr virus","volume":"53","author":"Flavell","year":"2000","journal-title":"Mol Pathol"},{"issue":"Suppl 5","key":"10.1016\/j.hemonc.2013.12.002_b0020","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1093\/annonc\/9.suppl_5.S45","article-title":"The many faces of Hodgkin\u2019s disease around the world: what have we learned from its pathology?","volume":"9","author":"Harris","year":"1998","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.hemonc.2013.12.002_b0025","first-page":"108","article-title":"Epstein\u2013Barr virus-associated diseases in humans","volume":"71","author":"Kawa","year":"2000","journal-title":"Int J Hematol"},{"issue":"3","key":"10.1016\/j.hemonc.2013.12.002_b0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2613.2001.iep190.x","article-title":"Epstein\u2013Barr virus infection and human malignancies","volume":"82","author":"Niedobitek","year":"2001","journal-title":"Int J Exp Pathol"},{"issue":"1","key":"10.1016\/j.hemonc.2013.12.002_b0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1651-2227.1998.tb01377.x","article-title":"Epstein\u2013Barr virus infection and its role in the expanding spectrum of human diseases","volume":"87","author":"Okano","year":"1998","journal-title":"Acta Paediatr"},{"issue":"10","key":"10.1016\/j.hemonc.2013.12.002_b0040","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1002\/1097-0142(19930515)71:10<3124::AID-CNCR2820711038>3.0.CO;2-J","article-title":"Epstein\u2013Barr virus in Hodgkin disease. 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