{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:56Z","timestamp":1787841356693,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral T-cell lymphomas. It is characterised by extranodal infiltration and proliferation of malignant T-cells within the sinusoids of the liver, sinuses and red pulp of the spleen, and the bone marrow. The tumour cells express CD2 and CD3, but are CD4, CD5 and CD8 negative and express a clonally restricted gamma-delta (or less commonly alpha-beta) T-cell receptor. The disease has an aggressive clinical course associated with a poor prognosis. We highlight and report three patients from South Africa with HSTCL, all of whom had hepatosplenomegaly and cytopaenias, and despite being HIV seronegative and immunocompetent, had a poor outcome, with a mean survival of 7.5 months in the two evaluable patients. This rare entity has not previously been reported from South Africa and as yet needs to be adequately characterised in a population where lymphoma is the most common haematological malignancy in adults, and where approximately two thirds of the adult lymphoma population are HIV seropositive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2014.09.006","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T17:33:40Z","timestamp":1413221620000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Hepatosplenic T-cell lymphoma"],"prefix":"10.4103","volume":"8","author":[{"given":"Philippa","family":"Ashmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moosa","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Wiggill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Willem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinitha","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Lakha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"25","key":"10.1016\/j.hemonc.2014.09.006_b0005","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","article-title":"International T-Cell Lymphoma project. International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes","volume":"26","author":"Vose","year":"2008","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.hemonc.2014.09.006_b0010","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.hemonc.2014.09.006_b0015","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V75.11.2213.2213","article-title":"Hepatosplenic T-cell lymphoma: sinusal\/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta","volume":"75","author":"Farcet","year":"1990","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.hemonc.2014.09.006_b0020","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/annonc\/mdn751","article-title":"Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment","volume":"20","author":"Falchook","year":"2009","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.hemonc.2014.09.006_b0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clml.2012.09.002","article-title":"Intensive induction chemotherapy followed by early high-dose therapy and hematopoietic stem cell transplantation results in improved outcome for patients with hepatosplenic T-cell lymphoma: a single institution experience","volume":"13","author":"Voss","year":"2013","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"2","key":"10.1016\/j.hemonc.2014.09.006_b0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MPG.0b013e31802f6424","article-title":"Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease","volume":"44","author":"Mackey","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.hemonc.2014.09.006_b0035","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.leu.2401784","article-title":"Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990","volume":"14","author":"Weidmann","year":"2000","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.hemonc.2014.09.006_b0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cyto.b.20063","article-title":"Flow cytometric immunophenotypic profiles of mature gamma delta T-cell malignancies involving peripheral blood and bone marrow","volume":"67","author":"Ahmad","year":"2005","journal-title":"Cytometry B Clin Cytom"},{"issue":"9","key":"10.1016\/j.hemonc.2014.09.006_b0045","first-page":"1453","article-title":"Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma\/delta lymphoma","volume":"10","author":"Jonveaux","year":"1996","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.hemonc.2014.09.006_b0050","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1080\/10428190601126941","article-title":"Allogeneic stem cell transplantation for hepatosplenic gamma delta T-cell lymphoma","volume":"48","author":"Konuma","year":"2007","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"10.1016\/j.hemonc.2014.09.006_b0055","first-page":"E25","article-title":"Successful allogeneic bone marrow transplantation for hepatosplenic gammadelta T cell lymphoma","volume":"86","author":"Ooi","year":"2001","journal-title":"Haematologica"},{"issue":"S1","key":"10.1016\/j.hemonc.2014.09.006_b0060","first-page":"273","article-title":"The impact of HIV on Non-Hodgkin\u2019s Lymphoma at Chris Hani Baragwanath Hospital","volume":"92","author":"Patel","year":"2007","journal-title":"Haematologica"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387614000831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387614000831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201508020-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:50:21Z","timestamp":1787838621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201508020-00005"}},"subtitle":["A case series"],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2014.09.006","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}