{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:37Z","timestamp":1787841277812,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005703","name":"Akdeniz University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005703","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]\/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]\/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2015.04.003","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T08:20:30Z","timestamp":1430554830000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["inv (4)(p13q13) in patient with essential thrombocythemia"],"prefix":"10.4103","volume":"8","author":[{"given":"Cigdem","family":"Aydin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan Kemal","family":"Yucel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Undar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel Berker","family":"Karauzum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hemonc.2015.04.003_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1172-2-3","article-title":"Essential thrombocythemia","volume":"2","author":"Bri\u00e8re","year":"2007","journal-title":"Orphanet J Rare Dis"},{"issue":"5","key":"10.1016\/j.hemonc.2015.04.003_b0010","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2010-08-270033","article-title":"How I treat essential thrombocythemia","volume":"117","author":"Beer","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.hemonc.2015.04.003_b0015","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1182\/asheducation-2009.1.621","article-title":"Pathogenesis and management of essential thrombocythemia","author":"Beer","year":"2009","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"3","key":"10.1016\/j.hemonc.2015.04.003_b0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-2006-939430","article-title":"Epidemiology of the myeloproliferative disorders polycythemia vera and essential thrombocythemia","volume":"32","author":"Johansson","year":"2006","journal-title":"Semin Thromb Hemost"},{"issue":"10","key":"10.1016\/j.hemonc.2015.04.003_b0025","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1038\/sj.leu.2402638","article-title":"Acute myeloid leukemia (AML) having evolved from essential thrombocythemia (ET): distinctive chromosome abnormalities in patients treated with pipobroman or hydroxyurea","volume":"16","author":"Bernasconi","year":"2002","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.hemonc.2015.04.003_b0030","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1182\/blood.V91.2.616","article-title":"Acute myeloid leukemia and myelodysplastic syndrome following essential thrombocythemia treated with hydroxyurea: high proportion of cases with 17p deletion","volume":"91","author":"Sterkers","year":"1998","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.hemonc.2015.04.003_b0035","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1182\/blood-2006-12-064287","article-title":"Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia","volume":"110","author":"Vannucchi","year":"2007","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.hemonc.2015.04.003_b0040","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/sj.leu.2403902","article-title":"Clinical implications of the JAK2 V617F mutation in essential thrombocythemia","volume":"19","author":"Antonioli","year":"2005","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.hemonc.2015.04.003_b0045","first-page":"96","article-title":"The third international workshop on chromosomes in leukemia. Lund, Sweden, July 21\u201325, 1980. Introduction","volume":"4","author":"Mittelman","year":"1981","journal-title":"Cancer Genet Cytogenet"},{"issue":"2","key":"10.1016\/j.hemonc.2015.04.003_b0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02982575","article-title":"Clinical and pathological criteria for the diagnosis of essential thrombocythemia, polycythemia vera, and idiopathic myelofibrosis (agnogenic myeloid metaplasia)","volume":"76","author":"Michiels","year":"2002","journal-title":"Int J Hematol"},{"issue":"1","key":"10.1016\/j.hemonc.2015.04.003_b0055","first-page":"110","article-title":"Incidence of trisomy 8 and 9, deletion of D13S319 and D20S108 loci and BCR\/ABL translocation in non-treated essential thrombocythemia patients: an analysis of bone marrow cells using interphase fluorescence in situ hybridization","volume":"88","author":"Zamora","year":"2003","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.hemonc.2015.04.003_b0060","first-page":"381","article-title":"Cytogenetic findings in untreated patients with essential thrombocythemia","volume":"20","author":"Panani","year":"2006","journal-title":"In Vivo"},{"issue":"2","key":"10.1016\/j.hemonc.2015.04.003_b0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-4608(88)90136-7","article-title":"Inversion (4)(p13q28) in two cases of acute nonlymphocytic leukemia","volume":"36","author":"Iurlo","year":"1988","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"10.1016\/j.hemonc.2015.04.003_b0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajh.2830180110","article-title":"Lymphoma of host origin in a marrow transplant recipient in remission of acute myeloid leukemia and receiving cyclosporin A","volume":"18","author":"Bloom","year":"1985","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.hemonc.2015.04.003_b0075","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0165-4608(89)90237-9","article-title":"Acute nonlymphocytic leukemia in a patient with a constitutional inv(4)","volume":"39","author":"Sreekantaiah","year":"1989","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"10.1016\/j.hemonc.2015.04.003_b0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000063058","article-title":"Inv(4)(p14q27) in a case with de novo acute nonlymphocytic leukemia","volume":"108","author":"Benasayag","year":"2002","journal-title":"Acta Haematol"},{"issue":"4","key":"10.1016\/j.hemonc.2015.04.003_b0085","first-page":"243","article-title":"Incidence of breakpoints in pericentric inversions of chromosome 4","volume":"39","author":"Verma","year":"1996","journal-title":"Ann Genet"},{"issue":"1","key":"10.1016\/j.hemonc.2015.04.003_b0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/geno.1997.4788","article-title":"Genomic structure and assignment of the RhoH\/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization","volume":"43","author":"Dallery-Prudhomme","year":"1997","journal-title":"Genomics"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387615000308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387615000308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201508040-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:24Z","timestamp":1787838504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201508040-00006"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2015.04.003","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}