{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:57Z","timestamp":1787841297671,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T00:00:00Z","timestamp":1436054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Basophilia is commonly associated with chronic myelogenous leukemia, notably in the accelerated phase or during blast crisis. It is also associated with other myeloproliferative neoplasms. However, its association with acute leukemia is very rare and is described in association with acute basophilic leukemia and few acute myeloid leukemias (AMLs) with recurrent genetic abnormalities such as t(6;9)(p23;q34). Herein, we describe the morphological features and discuss the differential diagnosis of a case of AML with the blasts showing previously unreported unusual combination of megakaryoblastic and basophilic differentiation along with peripheral blood and bone marrow basophilia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2015.06.003","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:51:34Z","timestamp":1436403094000},"page":"30-33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Basophilia and megakaryoblastic differentiation in a case of acute myeloid leukemia"],"prefix":"10.4103","volume":"9","author":[{"given":"Sreejesh","family":"Sreedharanunni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narender","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hemonc.2015.06.003_b0005","series-title":"Blood cells. A practical guide","author":"Bain","year":"2006"},{"key":"10.1016\/j.hemonc.2015.06.003_b0010","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1309\/B4NVER1AJJ84CTUU","article-title":"Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis","volume":"127","author":"Soupir","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0015","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.hemonc.2015.06.003_b0020","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1034\/j.1600-0609.2001.t01-1-00487.x","article-title":"Acute basophilic leukemia","volume":"67","author":"Giagounidis","year":"2001","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cancergencyto.2010.08.012","article-title":"The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases","volume":"203","author":"Gupta","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.hemonc.2015.06.003_b0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/08880018.2014.883655","article-title":"A novel karyotype in acute myeloid leukemia with basophilia","volume":"31","author":"Servitzoglou","year":"2014","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0035","first-page":"299","article-title":"Acute myeloblastic leukemia with involvement of the basophilic cell line and anomalies of the short arm of chromosome 12 (12p)","volume":"301","author":"Daniel","year":"1985","journal-title":"C R Acad Sci III"},{"key":"10.1016\/j.hemonc.2015.06.003_b0040","first-page":"978","article-title":"CD7+ acute myeloid leukaemia with \u2018mature lymphoid\u2019 blast morphology, marrow basophilia and t(4;12)(q12;p13)","volume":"99","author":"Ma","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0045","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/sj.leu.2402263","article-title":"Marked bone marrow basophilia in a child with acute myeloid leukemia with a cryptic t(8;21)(q22;q22) chromosomal translocation","volume":"15","author":"Lorsbach","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.hemonc.2015.06.003_b0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/ajh.10446","article-title":"Acute basophilic leukemia: case report","volume":"76","author":"Gupta","year":"2004","journal-title":"Am J Hematol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0055","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/ajh.23789","article-title":"Acute myeloid leukemia with myelodysplasia-related changes showing basophilic differentiation","volume":"89","author":"Wells","year":"2014","journal-title":"Am J Hematol"},{"key":"10.1016\/j.hemonc.2015.06.003_b0060","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.5858\/2008-132-1021-CMAECM","article-title":"Concurrent megakaryocytic and erythroid chronic myelogenous leukemia blast crisis","volume":"132","author":"Westfall","year":"2008","journal-title":"Arch Pathol Lab Med"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387615000552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387615000552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201609010-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:56Z","timestamp":1787838536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201609010-00006"}},"subtitle":["An unusual morphological combination"],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2015.06.003","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}