{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:37:18Z","timestamp":1793878638173,"version":"4.7.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Malaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with\n                      <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                      infection. It is less frequently associated with\n                      <jats:italic toggle=\"yes\">Plasmodium vivax<\/jats:italic>\n                      . Here we report an unusual case of a 23-year-old healthy Nigerian man who presented with fever, microangiopathic hemolytic anemia, acute renal failure, and confusion, and was diagnosed as having cerebral malaria-related hemophagocytic lymphohistiocytosis caused by P. vivax infection. He was successfully treated with intravenous artesunate and doxycycline with dramatic clinical improvement.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,8,7]],"date-time":"2016-08-07T07:39:42Z","timestamp":1470555582000},"page":"34-37","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline"],"prefix":"10.4103","volume":"11","author":[{"given":"Sawsan","family":"Amireh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunwant","family":"Guron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hemonc.2016.06.001_b0005","series-title":"World malaria report","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.hemonc.2016.06.001_b0010","series-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.hemonc.2016.06.001_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/asheducation-2009.1.127","article-title":"Hemophagocytic lymphohistiocytosis (HLH) and related disorders","author":"Filipovich","year":"2009","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.hemonc.2016.06.001_b0020","doi-asserted-by":"crossref","first-page":"ofu034","DOI":"10.1093\/ofid\/ofu034","article-title":"Severe morbidity and mortality risk from malaria in the United States, 1985\u20132011","volume":"1","author":"Hwang","year":"2014","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.hemonc.2016.06.001_b0025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/1475-2875-13-304","article-title":"Severity in Plasmodium vivax malaria claiming global vigilance and exploration\u2014A tertiary care center-based cohort study","volume":"13","author":"Saravu","year":"2014","journal-title":"Malar J"},{"key":"10.1016\/j.hemonc.2016.06.001_b0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.hemonc.2016.06.001_b0035","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.hoc.2015.06.007","article-title":"Pathogenesis of hemophagocytic lymphohistiocytosis","volume":"29","author":"Filipovich","year":"2015","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.hemonc.2016.06.001_b0040","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1473-3099(07)70290-6","article-title":"Infections associated with hemophagocytic syndrome","volume":"7","author":"Rouphael","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.hemonc.2016.06.001_b0045","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s12098-014-1520-6","article-title":"Cerebral malaria due to Plasmodium vivax in a young infant","volume":"81","author":"Kumar","year":"2014","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.hemonc.2016.06.001_b0050","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/0972-5229.45084","article-title":"Cerebral malaria caused by Plasmodium vivax in adult subjects","volume":"12","author":"Sarkar","year":"2008","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.hemonc.2016.06.001_b0055","first-page":"2014","article-title":"Intracerebral bleed, right hemiparesis and seizures: an atypical presentation of vivax malaria","volume":"11","author":"Karanth","year":"2014","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.hemonc.2016.06.001_b0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4068\/cmj.2011.47.3.173","article-title":"Hemophagocytic lymphohistiocytosis (HLH) associated with Plasmodium vivax Infection: Case report and review of the literature","volume":"47","author":"Sung","year":"2011","journal-title":"Chonnam Med J"},{"key":"10.1016\/j.hemonc.2016.06.001_b0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/ajh.10390","article-title":"Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman","volume":"74","author":"Park","year":"2003","journal-title":"Am J Hematol"},{"key":"10.1016\/j.hemonc.2016.06.001_b0070","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00277-010-1042-x","article-title":"Plasmodium vivax malaria-associated hemophagocytic lymphohistiocytosis in a young man with pancytopenia and fever","volume":"90","author":"Bae","year":"2011","journal-title":"Ann Hematol"},{"key":"10.1016\/j.hemonc.2016.06.001_b0075","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4103\/0972-9062.126425","article-title":"Hemophagocytic syndrome associated with severe Plasmodium vivax malaria in a child in Bikaner (northwestern India)","volume":"50","author":"Tanwar","year":"2013","journal-title":"J Vector Borne 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