{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:32Z","timestamp":1787841332111,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/background:<\/jats:title>\n                    <jats:p>Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10\u2013 1028 days) after allo-HSCT. Causative pathogens were human herpesvirus-6 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6), enterococcus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), staphylococcus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), streptococcus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), varicella zoster virus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), cytomegalovirus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), John Cunningham virus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), adenovirus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), and\n                      <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1). The cumulative incidence of CNS infection was 4.1% at 1 year and 5.5% at 5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis revealed that high-risk disease status was a risk factor for developing CNS infection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .02), and that overall survival at 3 years after allo-HSCT was 33% in patients with CNS infection and 53% in those without CNS infection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .04).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2016.08.008","type":"journal-article","created":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T16:32:00Z","timestamp":1474216320000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Central nervous system infection following allogeneic hematopoietic stem cell 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