{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:19Z","timestamp":1787841319221,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Thrombocytopenia with absent radii (TAR) syndrome is a rare congenital disorder characterized by low platelet counts of various severity, bilateral absent radii but thumbs are usually present. TAR syndrome is not generally associated with bone marrow failure or malignancy. Janus kinase-2, myeloproliferative leukemia protein, and calreticulin are not mutated in TAR patients. Only four cases of leukemia were reported in TAR patients in the literature: three acute myeloid leukemia (AML) and one acute lymphoblastic leukemia. Of the three cases of AML found in TAR patient, only one was reported in an adult. We report a case of myelodysplastic syndrome progressing to AML with calreticulin driver mutation in an adult male with TAR syndrome who was successfully treated with hematopoietic allogeneic stem cell transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2017.02.001","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T03:01:39Z","timestamp":1487905299000},"page":"245-247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Acute myeloid leukemia in a patient with thrombocytopenia with absent radii"],"prefix":"10.4103","volume":"11","author":[{"given":"Maximilian","family":"Jameson-Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsiporah","family":"Shore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Al-Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Gergis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hemonc.2017.02.001_b0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00005792-196948060-00001","article-title":"Thrombocytopenia with absent radius (TAR)","volume":"48","author":"Hall","year":"1969","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.hemonc.2017.02.001_b0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.blre.2010.03.002","article-title":"Pathophysiology and management of inherited bone marrow failure syndromes","volume":"24","author":"Shimamura","year":"2010","journal-title":"Blood Rev"},{"key":"10.1016\/j.hemonc.2017.02.001_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/asheducation-2007.1.29","article-title":"Diagnosis, genetics, and management of inherited bone marrow failure syndromes","author":"Alter","year":"2007","journal-title":"Hematol Am Soc Hematol Educ Prog"},{"key":"10.1016\/j.hemonc.2017.02.001_b0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00043426-198821000-00010","article-title":"Thrombocytopenia with absent radii. 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