{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:22Z","timestamp":1790230402978,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Background:<\/jats:title>\n                    <jats:p>Improvements in curative treatments for many types of cancer have emerged over the past several decades, resulting in a growing population of long-term cancer survivors \u2013 of both adult and childhood cancers. Despite this incredible medical achievement, long-term survivors of cancer face a unique fear: the fear of relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a review of the literature for data on fear of relapse among cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The fear of cancer recurrence is present in survivors of childhood and adult cancers as well as family members and often leads to psychological sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Literature on the fear of cancer recurrence has begun to emerge. However, herein we provide a unique approach through the use of a metaphor: Cicero\u2019s story of Damocles\u2019 sword. We aim to outline the many fear-related and emotional challenges faced by cancer survivors with an extensive review of studies demonstrating such challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2018.01.005","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T12:35:15Z","timestamp":1519043715000},"page":"129-134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Damocles\u2019 syndrome revisited"],"prefix":"10.4103","volume":"11","author":[{"given":"Margaret","family":"Cupit-Link","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Syrjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrukh K.","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hemonc.2018.01.005_b0005","series-title":"The Damocles syndrome: psychosocial consequences of surviving childhood cancer","author":"Koocher","year":"1981"},{"key":"10.1016\/j.hemonc.2018.01.005_b0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1586\/14737140.1.2.163","article-title":"Living beyond the sword of Damocles: surviving childhood cancer","volume":"1","author":"Zebrack","year":"2001","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.hemonc.2018.01.005_b0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.hemonc.2018.01.005_b0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<821::AID-CNCR29>3.0.CO;2-T","article-title":"Survivorship in childhood cancer: a case statement for enhancement of the role of the American Cancer Society. Task Force on Children and Cancer of the American Cancer Society","volume":"83","author":"Haase","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.hemonc.2018.01.005_b0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/bmt.2015.228","article-title":"Childhood to adult transition and long-term follow-up after blood and marrow transplantation","volume":"51","author":"Cupit","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.hemonc.2018.01.005_b0030","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11764-016-0589-5","article-title":"Emotional distress impacts quality of life evaluation: a report from the childhood cancer survivor study","volume":"11","author":"Huang","year":"2017","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.hemonc.2018.01.005_b0035","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw046","article-title":"Chronic conditions and utility-based health-related quality of life in adult childhood cancer survivors","volume":"108","author":"Yeh","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.hemonc.2018.01.005_b0040","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1158\/1055-9965.EPI-14-1418","article-title":"Survivors of childhood cancer in the United States: prevalence and burden of morbidity","volume":"24","author":"Phillips","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.hemonc.2018.01.005_b0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1017\/S1478951514000297","article-title":"Anxiety among adolescent survivors of pediatric cancer: a missing link in the survivorship literature","volume":"13","author":"McDonnell","year":"2015","journal-title":"Palliat Support Care"},{"key":"10.1016\/j.hemonc.2018.01.005_b0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cpr.2005.10.002","article-title":"A systematic and conceptual review of posttraumatic stress in childhood cancer survivors and their parents","volume":"26","author":"Bruce","year":"2006","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.hemonc.2018.01.005_b0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1651-2227.2000.tb01221.x","article-title":"Self-esteem, depression and anxiety among Swedish children and adolescents on and off cancer treatment","volume":"89","author":"von Essen","year":"2000","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.hemonc.2018.01.005_b0060","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.ejca.2010.03.001","article-title":"Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence","volume":"46","author":"Seitz","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.hemonc.2018.01.005_b0065","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1542\/peds.110.1.42","article-title":"Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin\u2019s disease, and non-Hodgkin\u2019s lymphoma: a report from the Childhood Cancer Survivor Study","volume":"110","author":"Zebrack","year":"2002","journal-title":"Pediatric"},{"key":"10.1016\/j.hemonc.2018.01.005_b0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/pbc.25773","article-title":"Psychosocial late effects in pediatric cancer survivors: a report from the Children\u2019s Oncology Group","volume":"63","author":"Bitsko","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.hemonc.2018.01.005_b0075","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1200\/JCO.2008.21.1433","article-title":"Psychological status in childhood cancer survivors: a report from the Childhood Cancer Survivor Study","volume":"27","author":"Zeltzer","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/pbc.20942","article-title":"Posttraumatic stress disorder (PTSD) in young adult survivors of childhood cancer","volume":"49","author":"Rourke","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.hemonc.2018.01.005_b0085","first-page":"389","article-title":"Psychosocial aspects of survivors of childhood cancer or leukemia","volume":"57","author":"Massimo","year":"2005","journal-title":"Minerva Pediatr"},{"key":"10.1016\/j.hemonc.2018.01.005_b0090","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/jpepsy\/25.6.449","article-title":"Examining the psychological consequences of surviving childhood cancer: systematic review as a research method in pediatric psychology","volume":"25","author":"Eiser","year":"2000","journal-title":"J Pediatr Psychol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0095","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1200\/JCO.2009.25.9564","article-title":"Psychological outcomes and health beliefs in adolescent and young adult survivors of childhood cancer and controls","volume":"28","author":"Kazak","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0100","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1200\/JCO.2009.22.8635","article-title":"Suicide ideation in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study","volume":"28","author":"Recklitis","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0105","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11912-008-0072-1","article-title":"Psychosocial support of the pediatric cancer patient: lessons learned over the past 50 years","volume":"10","author":"Askins","year":"2008","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.hemonc.2018.01.005_b0110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1545-5300.1992.00383.x","article-title":"Lives in a balance: perceived family functioning and the psychosocial adjustment of adolescent cancer survivors","volume":"31","author":"Rait","year":"1992","journal-title":"Fam Process"},{"key":"10.1016\/j.hemonc.2018.01.005_b0115","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0031-3955(02)00036-6","article-title":"The psychological effect of childhood cancer on families","volume":"49","author":"Giammona","year":"2002","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.hemonc.2018.01.005_b0120","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1037\/0893-3200.21.3.407","article-title":"A meta-analytic review of the influence of pediatric cancer on parent and family functioning","volume":"21","author":"Pai","year":"2007","journal-title":"J Fam Psychol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0033-3182(96)71577-3","article-title":"Posttraumatic stress disorder in mothers of pediatric cancer survivors","volume":"37","author":"Pelcovitz","year":"1996","journal-title":"Psychosomatics"},{"key":"10.1016\/j.hemonc.2018.01.005_b0130","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1542\/peds.63.4.616","article-title":"Psychologic adjustment of siblings of children with chronic illness","volume":"63","author":"Lavigne","year":"1979","journal-title":"Pediatrics"},{"key":"10.1016\/j.hemonc.2018.01.005_b0135","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/adc.2002.012088","article-title":"The siblings of childhood cancer patients need early support: a follow up study over the first year","volume":"89","author":"Lahteenmaki","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.hemonc.2018.01.005_b0140","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/pon.759","article-title":"Quality of life and psychological adaptation in siblings of paediatric cancer patients, 2 years after diagnosis","volume":"13","author":"Houtzager","year":"2004","journal-title":"Psychooncology"},{"key":"10.1016\/j.hemonc.2018.01.005_b0145","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jpsychores.2014.03.103","article-title":"Prevalence of posttraumatic stress disorder (PTSD) in women with breast cancer","volume":"76","author":"Kwakkenbos","year":"2014","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.hemonc.2018.01.005_b0150","first-page":"473","article-title":"A systematic literature review exploring the prevalence of post-traumatic stress disorder and the role played by stress and traumatic stress in breast cancer diagnosis and trajectory","volume":"9","author":"Arnaboldi","year":"2017","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"10.1016\/j.hemonc.2018.01.005_b0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/pon.3452","article-title":"Fear of recurrence in long-term breast cancer survivors\u2014still an issue. Results on prevalence, determinants, and the association with quality of life and depression from the cancer survivorship\u2014a multi-regional population-based study","volume":"23","author":"Koch","year":"2014","journal-title":"Psychooncology"},{"key":"10.1016\/j.hemonc.2018.01.005_b0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11764-013-0272-z","article-title":"Fear of cancer recurrence in adult cancer survivors: a systematic review of quantitative studies","volume":"7","author":"Simard","year":"2013","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.hemonc.2018.01.005_b0165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3949\/ccjm.84a.15159","article-title":"Living with hematologic cancer: recommendations, solutions","volume":"84","author":"Faiman","year":"2017","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.hemonc.2018.01.005_b0170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/asheducation-2011.1.128","article-title":"Educational session: managing chronic myeloid leukemia as a chronic disease","volume":"2011","author":"Hochhaus","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.hemonc.2018.01.005_b0175","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/pon.894","article-title":"Fear of recurrence, sense of coherence and posttraumatic stress disorder in haematological cancer survivors","volume":"14","author":"Black","year":"2005","journal-title":"Psychooncology"},{"key":"10.1016\/j.hemonc.2018.01.005_b0180","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1037\/a0022566","article-title":"Cancer patients with major depressive disorder: testing a biobehavioral\/cognitive behavior intervention","volume":"79","author":"Brothers","year":"2011","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0185","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1200\/JCO.2016.70.5301","article-title":"Efficacy of blended cognitive behavior therapy for high fear of recurrence in breast, prostate, and colorectal cancer survivors: the SWORD study, a randomized controlled trial","volume":"35","author":"van de Wal","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0190","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jpepsy\/jsi013","article-title":"Evidence-based interventions for survivors of childhood cancer and their families","volume":"30","author":"Kazak","year":"2005","journal-title":"J Pediatr Psychol"},{"key":"10.1016\/j.hemonc.2018.01.005_b0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10865-005-9036-1","article-title":"Cognitive behavioral therapy techniques for distress and pain in breast cancer patients: a meta-analysis","volume":"29","author":"Tatrow","year":"2006","journal-title":"J Behav Med"},{"key":"10.1016\/j.hemonc.2018.01.005_b0200","first-page":"30","article-title":"Current diagnosis and treatment of anxiety disorders","volume":"38","author":"Bystritsky","year":"2013","journal-title":"P T"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387618300244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387618300244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201811030-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:54Z","timestamp":1787838594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201811030-00002"}},"subtitle":["Update on the fear of cancer recurrence in the complex world of today\u2019s treatments and survivorship"],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2018.01.005","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}