{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:02:20Z","timestamp":1790035340692,"version":"4.0.1"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Several studies showed conflicting results about prognosis and predictors of outcome of critically ill patients with hematological malignancies (HM). The aim of this study is to determine the hospital outcome of critically ill patients with HM and the factors predicting the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials:<\/jats:title>\n                    <jats:p>All patients with HM admitted to MICU at a tertiary academic medical center were enrolled. Clinical data upon admission and during ICU stay were collected. Hospital, ICU, and 6 months outcomes were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 130 HM patients during the study period. Acute Leukemia was the most common malignancy (31.5%) followed by Non-Hodgkin\u2019s Lymphoma (28.5%). About 12.5% patients had autologous HSCT and 51.5% had allogeneic HSCT. Sepsis was the most common ICU diagnosis (25.9%). ICU mortality and hospital mortality were 24.8% and 45.3%, respectively. Six months mortality (available on 80% of patients) was 56.7%. Hospital mortality was higher among mechanically ventilated patients (75%). Using multivariate analysis, only mechanical ventilation (OR of 19.0, CI: 3.1\u2013117.4,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.001) and allogeneic HSCT (OR of 10.9, CI: 1.8\u201366.9,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.01) predicted hospital mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Overall hospital outcome of critically ill patients with HM is improving. However those who require mechanical ventilation or underwent allogeneic HSCT continue to have poor outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2018.03.003","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T21:43:09Z","timestamp":1523914989000},"page":"206-218","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Predictors of outcome in patients with hematologic malignancies admitted to the intensive care unit"],"prefix":"10.4103","volume":"11","author":[{"given":"Nassar","family":"Al-Zubaidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Shehada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Alshabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane","family":"ZazaDitYafawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Kingah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman O.","family":"Soubani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"13","key":"10.1016\/j.hemonc.2018.03.003_b0005","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/cncr.30003","article-title":"Changes in the survival of older patients with hematologic malignancies in the early 21st century","volume":"122","author":"Pulte","year":"2016","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.hemonc.2018.03.003_b0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1200\/JCO.2010.33.8897","article-title":"Hematologic malignancies: where do we stand in 2011?","volume":"29","author":"Kantarjian","year":"2011","journal-title":"J Clin Oncol"},{"issue":"15","key":"10.1016\/j.hemonc.2018.03.003_b0015","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2013-10-492223","article-title":"Advances in the treatment of hematologic malignancies using immunoconjugates","volume":"123","author":"Palanca-Wessels","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.hemonc.2018.03.003_b0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.blre.2015.04.002","article-title":"Managing critically Ill hematology patients: time to think differently","volume":"29","author":"Azoulay","year":"2015","journal-title":"Blood Rev"},{"key":"10.1016\/j.hemonc.2018.03.003_b0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0002-9343(83)90340-6","article-title":"Precedents for a meaningful recovery during treatment in a medical intensive care unit","volume":"75","author":"Schuster","year":"1983","journal-title":"Am J Med"},{"key":"10.1016\/j.hemonc.2018.03.003_b0030","doi-asserted-by":"crossref","unstructured":"Lloyed-Thomas AR, Wright I, Lister TA, Hinds CJ. 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