{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:40Z","timestamp":1787841340914,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Acute Promyelocytic Leukemia (APML) is a malignancy of cells in myeloid lineage. It is a neoplasm described by proliferation and accumulation of immature neutrophils called promyelocytes in the bone marrow, inhibiting normal cell production, which results in lower numbers of blood cells circulating the body. A minor but significant proportion of patients with APML harbor complex and cryptic rearrangements. Presence of isoderivative 17 with t(15;17) is very rare. We report a case of adult APML with amplification of\n                      <jats:italic toggle=\"yes\">RAR\u03b1\/PML<\/jats:italic>\n                      fusion protein, a consequence of isoderivative 17 with duplication of normal chromosome 15 and 17 and\n                      <jats:italic toggle=\"yes\">Tp53<\/jats:italic>\n                      deletion on derivative 17. Immunophenotyping by flow cytometry, presence of pancytopenia and epistaxis helped classify the patient as APML. FISH was used for confirmation of the same and indicated involvement of additional abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2019.02.002","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T10:42:10Z","timestamp":1554547330000},"page":"248-250","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Isoderivative chromosome 17 with multiple copies of RAR\u03b1\u2013PML fusions and Tp53 deletion in a rare case of APML"],"prefix":"10.4103","volume":"13","author":[{"given":"Dhanlaxmi","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Talker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Sengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papagudi G.","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20241211","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.5858\/arpa.2013-0345-RS","article-title":"Acute promyelocytic leukemia: a review and discussion of variant translocations","volume":"139","author":"Adams","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"R2-11-20241211","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3324\/haematol.2010.030205","article-title":"Impact of additional chromosomal abnormalities in patients with acute promyelocytic leukemia: 10-year results of the Japan Adult Leukemia Study Group APL97 study","volume":"96","author":"Ono","year":"2011","journal-title":"Haematologica"},{"key":"R3-11-20241211","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cancergen.2015.08.001","article-title":"Acute promyelocytic leukemia with isochromosome 17q and cryptic PML-RAR\u03b1 successfully treated with all-trans retinoic acid and arsenic trioxide","volume":"208","author":"Shepshelovich","year":"2015","journal-title":"Cancer Genet"},{"key":"R4-11-20241211","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000294959","article-title":"Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RAR\u03b1-PML fusion gene: report of 4 cases and review of the literature","volume":"123","author":"Manola","year":"2010","journal-title":"Acta Haematol"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387619300251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387619300251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2019.02.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:50:24Z","timestamp":1787838624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2019.02.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2019.02.002","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}