{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:30:45Z","timestamp":1787841045373,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T00:00:00Z","timestamp":1570233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Pseudo-Gaucher cells can be found in multiple hematologic malignancies, hemoglobinopathies, infections, and multiple storage disorders upon bone marrow aspirate and biopsy; however, Gaucher disease (GD) should be ruled out, particularly when the cytoplasmic inclusions cannot be adequately characterized. It is well known that GD may be associated with monoclonal gammopathies; however, although enzyme replacement therapy (ERT) may result in an improvement in polyclonal gammopathies, its effect on the progression of monoclonal gammopathy of undetermined significance to multiple myeloma (MM) remains uncertain. ERT may improve patient\u2019s cytopenias and facilitate administration of anti-myeloma therapy in patients with concurrent GD and MM; however, the current paucity of data makes it challenging to determine its effect on response to anti-myeloma therapy or the risk of relapse. Hematologists should be familiar with the clinical presentation and diagnosis of GD and its association with monoclonal gammopathies. Here we present a case of synchronous smoldering MM and GD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2019.07.001","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:33:00Z","timestamp":1570649580000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Synchronous multiple myeloma and Gaucher disease"],"prefix":"10.4103","volume":"13","author":[{"given":"Jorge","family":"Monge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Gergis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20241211","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.4081\/cp.2018.1061","article-title":"Bone marrow abnormalities detected by magnetic resonance imaging as initial sign of hematologic malignancies","volume":"8","author":"Gronningsaeter","year":"2018","journal-title":"Clin Pract"},{"key":"R2-7-20241211","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2214\/AJR.11.7420","article-title":"MRI of spinal bone marrow: Part 2. T1-weighted imaging-based differential diagnosis","volume":"197","author":"Hanrahan","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"R3-7-20241211","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4065\/78.1.21","article-title":"Review of 1027 patients with newly diagnosed multiple myeloma","volume":"78","author":"Kyle","year":"2003","journal-title":"Mayo Clin Proc"},{"key":"R4-7-20241211","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1200\/JCO.2006.08.5803","article-title":"Magnetic resonance imaging in multiple myeloma: diagnostic and clinical implications","volume":"25","author":"Walker","year":"2007","journal-title":"J Clin Oncol"},{"key":"R5-7-20241211","first-page":"351","article-title":"Crystal-storing histiocytosis and crystalline tissue deposition in multiple myeloma","volume":"115","author":"Yamamoto","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"R6-7-20241211","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0344-0338(96)80037-9","article-title":"Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudopseudo-Gaucher cells. 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Report of 16 cases","volume":"31","author":"Pratt","year":"1968","journal-title":"Blood"},{"key":"R12-7-20241211","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00277-008-0441-8","article-title":"Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature","volume":"87","author":"de Fost","year":"2008","journal-title":"Ann Hematol"},{"key":"R13-7-20241211","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bcmd.2005.08.004","article-title":"Increased incidence of cancer in adult Gaucher disease in Western Europe","volume":"36","author":"de Fost","year":"2006","journal-title":"Blood Cells Mol Dis"},{"key":"R14-7-20241211","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1182\/blood-2018-02-834689","article-title":"MGUS, lymphoplasmacytic malignancies, and Gaucher disease: the significance of the clinical association","volume":"131","author":"Weinreb","year":"2018","journal-title":"Blood"},{"key":"R15-7-20241211","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/bjh.12335","article-title":"Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature","volume":"161","author":"Arends","year":"2013","journal-title":"Br J Haematol"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387619300731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387619300731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2019.07.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:41:08Z","timestamp":1787838068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2019.07.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2019.07.001","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}