{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:57Z","timestamp":1787841297975,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR\u2013TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed\n                      <jats:italic toggle=\"yes\">FGFR3\u2013TACC3<\/jats:italic>\n                      gene fusion, so screening for this mutation at diagnosis is not recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2020.02.005","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T03:12:20Z","timestamp":1584328340000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Absence of FGFR3\u2013TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration"],"prefix":"10.4103","volume":"14","author":[{"given":"C.","family":"Banella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ginevrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Falconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Divona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Curzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Panetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Voso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.I.","family":"Noguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-14-20241211","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.1220834","article-title":"Transforming fusions of FGFR and TACC genes in human glioblastoma","volume":"337","author":"Singh","year":"2012","journal-title":"Science"},{"key":"R3-14-20241211","first-page":"475","article-title":"FGFR\u2013TACC gene fusions in human glioma","volume":"19","author":"Lasorella","year":"2017","journal-title":"Neuro Oncol"},{"key":"R4-14-20241211","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1158\/1541-7786.MCR-15-0497","article-title":"Oncogenic gene fusion FGFR3\u2013TACC3 is regulated by tyrosine phosphorylation","volume":"14","author":"Nelson","year":"2016","journal-title":"Mol Cancer Res"},{"key":"R5-14-20241211","doi-asserted-by":"crossref","first-page":"84587","DOI":"10.18632\/oncotarget.13139","article-title":"FGFR3, as a receptor tyrosine kinase, is associated with differentiated biological functions and improved survival of glioma patients","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"R6-14-20241211","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41389-017-0018-2","article-title":"Novel therapeutic strategy for cervical cancer harboring FGFR3\u2013TACC3 fusions","volume":"7","author":"Tamura","year":"2018","journal-title":"Oncogenesis"},{"key":"R7-14-20241211","doi-asserted-by":"crossref","first-page":"26374","DOI":"10.18632\/oncotarget.8380","article-title":"Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"R8-14-20241211","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1158\/1541-7786.MCR-10-0168","article-title":"Roles of fibroblast growth factor receptors in carcinogenesis","volume":"8","author":"Haugsten","year":"2010","journal-title":"Mol Cancer Res"},{"key":"R9-14-20241211","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1158\/1078-0432.CCR-14-3212","article-title":"The FGFR landscape in cancer: analysis of 4,853 tumors by next-generation sequencing","volume":"22","author":"Helsten","year":"2016","journal-title":"Clin Cancer Res"},{"key":"R10-14-20241211","doi-asserted-by":"crossref","first-page":"55929","DOI":"10.18632\/oncotarget.10482","article-title":"FGFR3-TACC3 fusion in solid tumors: mini review","volume":"7","author":"Costa","year":"2016","journal-title":"Oncotarget"},{"key":"R11-14-20241211","doi-asserted-by":"crossref","first-page":"66386","DOI":"10.18632\/oncotarget.11964","article-title":"PML\/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity","volume":"7","author":"Noguera","year":"2016","journal-title":"Oncotarget"},{"key":"R13-14-20241211","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0609.2008.01155.x","article-title":"Detection of the nucleophosmin gene mutations in acute myelogenous leukemia through RT\u2013PCR and polyacrylamide gel electrophoresis","volume":"82","author":"Calvo","year":"2009","journal-title":"Eur J Haematol"},{"key":"R14-14-20241211","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1158\/1078-0432.CCR-14-2199","article-title":"Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma","volume":"21","author":"Di Stefano","year":"2015","journal-title":"Clin Cancer Res"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387620300376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387620300376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2020.02.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:59Z","timestamp":1787838539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2020.02.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2020.02.005","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}