{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:36:09Z","timestamp":1792064169106,"version":"4.4.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"\n Objective\/Background:<\/jats:title>\n The purpose of this study was to evaluate serum cardiac troponin I and serum N-terminal (NT) pro-brain natriuretic peptide (pro-BNP) levels and the utility of tissue Doppler imaging in assessing cardiovascular changes following left ventricular (LV) dysfunction in children with beta-thalassemia major (\u03b2-TM). In children with \u03b2-TM who depend on regular blood transfusion, cardiac iron toxicity is a common serious complication. The most common cause of death among these patients is congestive heart failure.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This is a cross-sectional study which included 50 patients with \u03b2-TM and 50 healthy controls. Tissue Doppler imaging was performed and levels of serum ferritin, cardiac troponin I, and NT pro-BNP were estimated for all included patients.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Serum NT pro-BNP and cardiac troponin (cTnI) showed a significant increase in patients with \u03b2-TM (\n p<\/jats:italic>\n < .001). In patients with \u03b2-TM, LV dimensions (LV end systolic diameter) and (LV end diastolic diameter) were large (\n p<\/jats:italic>\n < .01); LVmass (\n p<\/jats:italic>\n < .01), Ewave, and E\/A ratio (\n p<\/jats:italic>\n < .01) were high (\n p<\/jats:italic>\n < .05); and deceleration time was short (\n p<\/jats:italic>\n < .05). Besides, transmitral ratio (E\/E\n m<\/jats:sub>\n ) (\n p<\/jats:italic>\n < .05) and tricuspid valve velocity were higher (\n p<\/jats:italic>\n < .05), and early diastolic velocity (E\n m<\/jats:sub>\n )(\n p<\/jats:italic>\n < .05) and systolic wave velocity (S\n m<\/jats:sub>\n ) were lower in patients with \u03b2-TM(\n p<\/jats:italic>\n < .05). Asignificant positive correlation was detected between the pro-BNP and Ewave (\n r<\/jats:italic>\n = 0.558,\n p<\/jats:italic>\n < .001), E\/A ratio (\n r<\/jats:italic>\n = 0.403,\n p<\/jats:italic>\n < .001), E\/E\n m<\/jats:sub>\n ratio (\n r<\/jats:italic>\n = 0.576,\n p<\/jats:italic>\n < .001), and ferritin (\n r<\/jats:italic>\n = 0.545,\n p<\/jats:italic>\n < .001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Pulsed wave tissue Doppler imaging and NT pro-BNP had a significant role in the estimation of ventricular dysfunction in children with \u03b2-TM.<\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.hemonc.2020.07.003","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T22:15:31Z","timestamp":1596060931000},"page":"206-213","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of ventricular dysfunction in Egyptian children with Beta-thalassemia major"],"prefix":"10.4103","volume":"14","author":[{"given":"Salem E.","family":"Deraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh A. 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