{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:25Z","timestamp":1787841325077,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Background:<\/jats:title>\n                    <jats:p>Lymphoma is a common human cancer that shows a variable geographic incidence worldwide. It is the fourth most common cancer in Jordan. Systemic reports of descriptive epidemiology on lymphoma from the Middle East are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A nationwide multi-institutional retrospective study was conducted covering all major hospitals and laboratories that provide diagnostic services. We collected data on all cases diagnosed with lymphoma between 2014 and 2019. The included variables were patients\u2019 age, gender, anatomic site, and the histologic type according to the World Health Organization classification system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 4189 cases were diagnosed with lymphoma. There was a statistically significant gender difference (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .05), as 57.5% of patients were males. The peak incidence occurred at age 25-55 years. There were 1,652 (39%) cases of Hodgkin lymphoma (HL) and 2,537 (61%) of non-Hodgkin lymphoma (NHL), where nodular sclerosis (67%) and diffuse large B-cell lymphoma (53%) were the most common subtypes, respectively. The average age-adjusted incidence rates per 100,000 population were 8.01 for all lymphomas, 4.33 for NHL, and 3.16 for HL and all remained stable over the 6 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HL is the most common lymphoma in Jordan, with a percentage higher than most of reported studies in Asian and Western countries. It also shows a unimodal distribution of age-specific incidence rates, with a single peak in young adults. The incidence rate of HL is higher than Eastern countries but comparable to the West. In contrast, NHL demonstrates a lower incidence rate than Western countries but a similar distribution of subtypes, as mature T\/natural killer-cell lymphomas were rare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.hemonc.2020.10.002","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T21:51:10Z","timestamp":1605045070000},"page":"336-342","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["The epidemiology of lymphoma in Jordan"],"prefix":"10.4103","volume":"14","author":[{"given":"Tariq N.","family":"Aladily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiam","family":"Khreisat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ashukhaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohaib M.","family":"Alkhatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Annab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musleh S.","family":"Tarawneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaher S.","family":"Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam Abu","family":"Farsakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Mahgoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadwa","family":"Bustami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad T.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif Aldeen","family":"AlRyalat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalla S.","family":"Abbadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Al-Fararjeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Sughayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-8-20241211","first-page":"68","article-title":"On some morbid appearances of the absorbent glands and spleen","volume":"17","author":"Hodgkin","year":"1932","journal-title":"Med Chir Trans"},{"key":"R5-8-20241211","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B","article-title":"Follicular lymphoma; a reevaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases","volume":"9","author":"Rappaport","year":"1965","journal-title":"Cancer"},{"key":"R6-8-20241211","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/1097-0142(197410)34:8+<1488::AID-CNCR2820340822>3.0.CO;2-C","article-title":"Immunologic characterization of human malignant lymphomas","volume":"34","author":"Lukes","year":"1974","journal-title":"Cancer"},{"key":"R7-8-20241211","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0140-6736(74)91786-3","article-title":"Classification of non-Hodgkin\u2019s lymphoma\u2019s","volume":"304","author":"Garard-Marchant","year":"1974","journal-title":"Lancet"},{"key":"R8-8-20241211","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"R10-8-20241211","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5045\/kjh.2012.47.2.92","article-title":"Epidemiologic overview of malignant lymphoma","volume":"47","author":"Huh","year":"2012","journal-title":"Korean J Hematol"},{"key":"R11-8-20241211","first-page":"368","article-title":"Comparison of the incidence and trends of hematologic malignancies between Japan and the United States","volume":"56","author":"Chihara","year":"2015","journal-title":"Rinsho Ketsueki"},{"key":"R12-8-20241211","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"R15-8-20241211","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12185-018-2403-9","article-title":"CISL. Lymphoma epidemiology in Korea and the real clinical field including the Consortium of Improving Survival of Lymphoma (CISL) trial","volume":"107","author":"Yoo","year":"2018","journal-title":"Int J Hematol"},{"key":"R16-8-20241211","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/hon.2392","article-title":"Non-Hodgkin lymphoma in South East Asia: an analysis of the histopathology, clinical features, and survival from Thailand","volume":"36","author":"Intragumtornchai","year":"2018","journal-title":"Hematol Oncol"},{"key":"R17-8-20241211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21147\/j.issn.1000-9604.2018.01.01","article-title":"Cancer incidence and mortality in China, 2014","volume":"30","author":"Chen","year":"2018","journal-title":"Chin J Cancer Res"},{"key":"R18-8-20241211","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/bjc.2015.94","article-title":"Lymphoma incidence, survival and prevalence 2004\u20132014: sub-type analysis from the UK\u2019s Haematological Malignancy Research Network","volume":"112","author":"Smith","year":"2015","journal-title":"Br J Cancer"},{"key":"R20-8-20241211","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s12185-018-2430-6","article-title":"Epidemiology of malignant lymphoma and recent progress in research on adult T-cell leukemia\/lymphoma in Japan","volume":"107","author":"Miyoshi","year":"2016","journal-title":"Int J Hematol"},{"key":"R21-8-20241211","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3322\/caac.21357","article-title":"2016 US lymphoid malignancy statistics by World Health Organization subtypes","volume":"66","author":"Teras","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"R22-8-20241211","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur J Cancer"},{"key":"R24-8-20241211","first-page":"1917","article-title":"Hodgkins lymphoma in North Jordan, Does it have a different pattern","volume":"25","author":"Almasri","year":"2004","journal-title":"Saudi Med J"},{"key":"R25-8-20241211","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.hemonc.2013.12.002","article-title":"Epstein-Barr virus and Hodgkin lymphoma in Jordan","volume":"7","author":"Sughayer","year":"2014","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"R26-8-20241211","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000447577","article-title":"Epidemiology of Non-Hodgkin\u2019s lymphoma in India","volume":"91","author":"Nair","year":"2016","journal-title":"Oncology"},{"key":"R27-8-20241211","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cll.2017.10.007","article-title":"Lymphoma and pathology in Sub-Saharan Africa: current approaches and future directions","volume":"38","author":"Tomoka","year":"2018","journal-title":"Clin Lab Med"},{"key":"R28-8-20241211","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"key":"R29-8-20241211","doi-asserted-by":"crossref","first-page":"2937067","DOI":"10.1155\/2018\/2937067","article-title":"The epidemiology and trend of cancer in Jordan, 2000\u20132013","volume":"2018","author":"Khader","year":"2018","journal-title":"J Cancer Epidemiol"},{"key":"R30-8-20241211","doi-asserted-by":"crossref","first-page":"151406","DOI":"10.1016\/j.anndiagpath.2019.151406","article-title":"Epstein \u2013 Barr virus infection in de novo diffuse large B-cell lymphoma in Jordan and Turkey","volume":"43","author":"Aladily","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"R31-8-20241211","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.critrevonc.2017.01.009","article-title":"Primary mediastinal large B-cell lymphoma","volume":"113","author":"Martelli","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"R32-8-20241211","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.anndiagpath.2019.04.009","article-title":"The utility of CD83, fascin and CD23 in the differential diagnosis of primary mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma","volume":"40","author":"Aladily","year":"2019","journal-title":"Ann Diagn Pathol"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387620301710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387620301710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2020.10.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:55Z","timestamp":1787838595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.hemonc.2020.10.002"}},"subtitle":["A nationwide population study of 4189 cases according to World Health Organization classification system"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hemonc.2020.10.002","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}