{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:35:21Z","timestamp":1790055321978,"version":"4.0.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4292,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>TH1 cytokines have been suggested to contribute to the pathogenesis of T\u2013cell\u2013mediated liver injury and inflammation. However, the molecular signaling pathways involved in such injury are still poorly understood. In the present study, we investigated the role of the STAT1\/T\u2013bet signaling pathway in a murine model of T\u2013cell\u2013mediated liver inflammation induced by the application of concanavalin A (Con A) using newly created STAT1 transgenic mice as well as STAT1\u2013 and T\u2013bet\u2013deficient mice. Liver injury induced by Con A was associated with an increase of both pSTAT1 and T\u2013bet levels in the liver. Furthermore, functional studies suggested a pathogenic role for STAT1 in Con A\u2013induced liver injury, because transgenic mice overexpressing STAT1 under the control of the CD2 promoter\/enhancer construct showed elevated interferon gamma (IFN\u2013\u03b3) and IRF\u20131 levels as well as significantly augmented liver injury following administration of Con A. Consistently, we observed that both STAT1\u2013deficient and T\u2013bet\u2013deficient mice were protected from such T\u2013cell\u2013dependent liver injury. In conclusion, these findings suggest a key pathogenic role for the STAT1\/T\u2013bet signaling pathway for T\u2013cell activation in the Con A model of T\u2013cell\u2013mediated liver pathology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1016\/j.hep.2003.09.020","type":"journal-article","created":{"date-parts":[[2003,11,25]],"date-time":"2003-11-25T20:29:01Z","timestamp":1069792141000},"page":"1573-1580","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["A Key Pathogenic Role for the Stat1\/T\u2013Bet Signaling Pathway in T\u2013Cell-Mediated Liver Inflammation"],"prefix":"10.1097","volume":"38","author":[{"given":"J\u00fcrgen","family":"Siebler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Protschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Blessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Galle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.hep.2003.09.020-BIB1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","volume":"90","author":"Tiegs","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hep.2003.09.020-BIB2","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4105::AID-IMMU4105>3.0.CO;2-8","volume":"28","author":"Tagawa","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB3","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hep.2003.09.020-BIB4","first-page":"209","volume-title":"Lymphokines","volume":"13","author":"Gough","year":"1987","unstructured":"Expression of hemopoietic growth factor genes in murine T lymphocytes. In: ed. Lymphokines. Volume 13. London: Academic, 1987:209-238."},{"key":"10.1016\/j.hep.2003.09.020-BIB5","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/hep.510240413","volume":"24","author":"Knolle","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.hep.2003.09.020-BIB6","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0002-9440(10)64804-3","volume":"157","author":"Schumann","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hep.2003.09.020-BIB7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jlb.62.6.702","volume":"62","author":"van Rooijen","year":"1997","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.hep.2003.09.020-BIB8","first-page":"190","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.hep.2003.09.020-BIB9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","volume":"111","author":"Kusters","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hep.2003.09.020-BIB10","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","volume":"159","author":"Tagawa","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB11","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.179.5.1529","volume":"179","author":"Mizuhara","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.hep.2003.09.020-BIB12","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.510300616","volume":"30","author":"Bozza","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.hep.2003.09.020-BIB13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)81289-1","volume":"84","author":"Durbin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.hep.2003.09.020-BIB14","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.163.12.6820","volume":"163","author":"Senaldi","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","volume":"84","author":"Meraz","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.hep.2003.09.020-BIB16","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.hep.2003.09.020-BIB17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/ni794","volume":"3","author":"Afkarian","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0602-567","volume":"8","author":"Neurath","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.hep.2003.09.020-BIB19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20011956","volume":"195","author":"Neurath","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.hep.2003.09.020-BIB20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0022-1759(95)00124-S","volume":"185","author":"Zhumabekov","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.hep.2003.09.020-BIB21","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1074\/jbc.271.10.5790","volume":"271","author":"Li","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hep.2003.09.020-BIB22","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.261570598","volume":"98","author":"Lighvani","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hep.2003.09.020-BIB23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4049\/jimmunol.167.1.514","volume":"167","author":"Streetz","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB24","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.4049\/jimmunol.166.2.1300","volume":"166","author":"Wolf","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.hep.2003.09.020-BIB25","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1281555","volume":"258","author":"Shuai","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.hep.2003.09.020-BIB26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0092-8674(94)90357-3","volume":"76","author":"Shuai","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.hep.2003.09.020-BIB27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0092-8674(89)90107-4","volume":"58","author":"Harada","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.hep.2003.09.020-BIB28","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1084\/jem.184.5.2043","volume":"184","author":"Duncan","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.hep.2003.09.020-BIB29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1074-7613(01)00103-0","volume":"14","author":"Grogan","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.hep.2003.09.020-BIB30","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1172\/JCI0215841","volume":"110","author":"Hong","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hep.2003.09.020-BIB31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1065544","volume":"295","author":"Finotto","year":"2002","journal-title":"Science"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.hep.2003.09.020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200312000-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:29:34Z","timestamp":1733052574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200312000-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003]]}},"URL":"https:\/\/doi.org\/10.1016\/j.hep.2003.09.020","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}