{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:29:14Z","timestamp":1789122554315,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Failure Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.hfc.2024.06.001","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T18:25:25Z","timestamp":1729103125000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Normal Hemodynamic Response to Exercise"],"prefix":"10.1016","volume":"21","author":[{"given":"Francesco","family":"Ferrara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreina","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vincenza","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bossone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.hfc.2024.06.001_bib1","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/ehjci\/jead250","article-title":"The clinical use of stress echocardiography in chronic coronary syndromes and beyond coronary artery disease: a clinical consensus statement from the European Association of Cardiovascular Imaging of the ESC","volume":"25","author":"Picano","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hfc.2024.06.001_bib2","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hfc.2024.06.001_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.hfc.2012.04.007","article-title":"Exercise-induced pulmonary hypertension","volume":"8","author":"Bossone","year":"2012","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.hfc.2024.06.001_bib4","series-title":"Pulmonary vascular physiology and physiopathology","first-page":"107","article-title":"Pulmonary circulation during exercise","author":"Reeves","year":"1989"},{"key":"10.1016\/j.hfc.2024.06.001_bib5","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1378\/chest.12-0071","article-title":"Exercise stress echocardiography of the pulmonary circulation: limits of normal and sex differences","volume":"142","author":"Argiento","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.hfc.2024.06.001_bib6","doi-asserted-by":"crossref","first-page":"2103181","DOI":"10.1183\/13993003.03181-2021","article-title":"Diagnostic, prognostic and differential-diagnostic relevance of pulmonary haemodynamic parameters during exercise: a systematic review","volume":"60","author":"Zeder","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hfc.2024.06.001_bib7","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCULATIONAHA.112.000667","article-title":"Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases","volume":"128","author":"Lewis","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.hfc.2024.06.001_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chest.2018.01.022","article-title":"Exercise-Induced Pulmonary Hypertension: Translating Pathophysiological Concepts Into Clinical Practice","volume":"154","author":"Naeije","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.hfc.2024.06.001_bib9","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"Vonk-Noordegraaf","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.hfc.2024.06.001_bib10","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/S0735-1097(99)00055-8","article-title":"Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: implications for the diagnosis of pulmonary hypertension","volume":"33","author":"Bossone","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.hfc.2024.06.001_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00003677-200401000-00006","article-title":"Vulnerability of pulmonary capillaries during exercise","volume":"32","author":"West","year":"2004","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.hfc.2024.06.001_bib12","doi-asserted-by":"crossref","first-page":"1700578","DOI":"10.1183\/13993003.00578-2017","article-title":"An official European Respiratory Society statement: pulmonary haemodynamics during exercise","volume":"50","author":"Kovacs","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hfc.2024.06.001_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1152\/japplphysiol.00372.2016","article-title":"Effects of body position on exercise capacity and pulmonary vascular pressure-flow relationships","volume":"121","author":"Forton","year":"2016","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.hfc.2024.06.001_bib14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1086\/683815","article-title":"Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice","volume":"5","author":"Berry","year":"2015","journal-title":"Pulm Circ"},{"key":"10.1016\/j.hfc.2024.06.001_bib15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/heartjnl-2015-308592","article-title":"The pulmonary artery wedge pressure response to sustained exercise is time-variant in healthy adults","volume":"102","author":"Wright","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.hfc.2024.06.001_bib16","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1249\/MSS.0000000000001227","article-title":"Pulmonary artery wedge pressure relative to exercise work rate in older men and women","volume":"49","author":"Esfandiari","year":"2017","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.hfc.2024.06.001_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jchf.2016.10.012","article-title":"The influence of age on hemodynamic parameters during rest and exercise in healthy individuals","volume":"5","author":"Wolsk","year":"2017","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.hfc.2024.06.001_bib18","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cardfail.2019.06.004","article-title":"Hemodynamic response to rapid saline infusion compared with exercise in healthy participants aged 20\u201380 years","volume":"25","author":"Andersen","year":"2019","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.hfc.2024.06.001_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701","article-title":"Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction","volume":"3","author":"Borlaug","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.hfc.2024.06.001_bib20","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm:a consensus recommendation from the Heart Failure Association (HFA), of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hfc.2024.06.001_bib21","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/ehf2.13979","article-title":"Exercise haemodynamics in heart failure with preserved ejection fraction: a systematic review and meta-analysis","volume":"9","author":"Baratto","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.hfc.2024.06.001_bib22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/cs0650653","article-title":"Influence of age on pulmonary haemodynamics at rest and during supine exercise","volume":"65","author":"Ehrsam","year":"1983","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.hfc.2024.06.001_bib23","doi-asserted-by":"crossref","first-page":"e004750","DOI":"10.1161\/CIRCHEARTFAILURE.117.004750","article-title":"Pulmonary capillary wedge pressure patterns during exercise predict exercise capacity and incident heart failure","volume":"11","author":"Eisman","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.hfc.2024.06.001_bib24","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1093\/eurheartj\/ehac716","article-title":"Economic, ethical, and environmental sustainability of cardiac imaging","volume":"44","author":"Picano","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hfc.2024.06.001_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.echo.2016.10.016","article-title":"The Clinical Use of Stress Echocardiography in Non-Ischaemic Heart Disease: Recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Lancellotti","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.hfc.2024.06.001_bib26","first-page":"527","article-title":"Stressing the cardiopulmonary vascular system: the role of echocardiography","volume":"31","author":"Rudski","year":"2018","journal-title":"JASE"},{"key":"10.1016\/j.hfc.2024.06.001_bib27","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.jacc.2023.09.807","article-title":"RIGHT Heart International NETwork (RIGHT-NET) Investigators. Exercise Stress Echocardiography of the Right Ventricle and Pulmonary Circulation","volume":"82","author":"Gargani","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.hfc.2024.06.001_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1378\/chest.09-2099","article-title":"Assessment of pulmonary arterial pressure during exercise in collagen vascular disease: echocardiography vs right-sided heart catheterization","volume":"138","author":"Kovacs","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.hfc.2024.06.001_bib29","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcmg.2015.06.018","article-title":"Accuracy of echocardiography to evaluate pulmonary vascular and RV function during exercise","volume":"9","author":"Claessen","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.hfc.2024.06.001_bib30","doi-asserted-by":"crossref","first-page":"e005711","DOI":"10.1161\/CIRCIMAGING.116.005711","article-title":"Accuracy of echocardiography to estimate pulmonary artery pressures with exercise: a simultaneous invasive-noninvasive comparison","volume":"10","author":"van Riel","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.hfc.2024.06.001_bib31","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1161\/CIRCULATIONAHA.108.800938","article-title":"Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia","volume":"119","author":"Gr\u00fcnig","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hfc.2024.06.001_bib32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/ejechocard\/jep024","article-title":"Effects of age on pulmonary artery systolic pressure at rest and during exercise in normal adults","volume":"10","author":"Mahjoub","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.hfc.2024.06.001_bib33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/hrt.2010.203471","article-title":"Inappropriate exercise-induced increase in pulmonary artery pressure in patients with systemic sclerosis","volume":"97","author":"D'Alto","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.hfc.2024.06.001_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2015.11.186","article-title":"Exercise testing can unmask right ventricular dysfunction in systemic sclerosis patients with normal resting pulmonary artery pressure","volume":"204","author":"Chia","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hfc.2024.06.001_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/echo.13396","article-title":"Echocardiographic assessment of right ventricular contractile reserve in healthy subjects","volume":"34","author":"D'Alto","year":"2017","journal-title":"Echocardiography"},{"key":"10.1016\/j.hfc.2024.06.001_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chest.2018.11.015","article-title":"Right ventricular functional reserve in early-stage idiopathic pulmonary fibrosis: an exercise two-dimensional speckle tracking doppler echocardiography study","volume":"155","author":"D'Andrea","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.hfc.2024.06.001_bib37","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s10554-020-01897-3","article-title":"Reduced pulmonary vascular reserve during stress echocardiography in confirmed pulmonary hypertension and patients at risk of overt pulmonary hypertension","volume":"36","author":"Wierzbowska-Drabik","year":"2020","journal-title":"Int J Cardiovasc Imag"},{"key":"10.1016\/j.hfc.2024.06.001_bib38","first-page":"451","article-title":"Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)","volume":"11","author":"Vriz","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.hfc.2024.06.001_bib39","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1093\/eurheartj\/ehy268","article-title":"Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction","volume":"39","author":"Obokata","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hfc.2024.06.001_bib40","article-title":"Utility of E\/e' ratio during low-level exercise to diagnose heart failure with preserved ejection fraction","author":"Harada","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.hfc.2024.06.001_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.hfc.2018.03.010","article-title":"The Right Heart International Network (RIGHT-NET): Rationale, Objectives, Methodology, and Clinical Implications","volume":"14","author":"Ferrara","year":"2018","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.hfc.2024.06.001_bib42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.hfc.2024.06.001_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.hfc.2024.06.001_bib44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the american society of echocardiography and the european association of cardiovascular imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.hfc.2024.06.001_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12947-021-00238-1","article-title":"A\u00a0multicentric quality-control study of exercise Doppler echocardiography of the right heart and the pulmonary circulation. The RIGHT Heart International NETwork (RIGHT-NET)","volume":"19","author":"Ferrara","year":"2021","journal-title":"Cardiovasc Ultrasound"},{"issue":"7","key":"10.1016\/j.hfc.2024.06.001_bib46","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s10554-021-02243-x","article-title":"Feasibility of semi-recumbent bicycle exercise Doppler echocardiography for the evaluation of the right heart and pulmonary circulation unit in different clinical conditions: the RIGHT heart international NETwork (RIGHT-NET)","volume":"37","author":"Ferrara","year":"2021","journal-title":"Int J Cardiovasc Imag"}],"container-title":["Heart Failure Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551713624000436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551713624000436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:11:29Z","timestamp":1756192289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551713624000436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1551713624000436"],"URL":"https:\/\/doi.org\/10.1016\/j.hfc.2024.06.001","relation":{},"ISSN":["1551-7136"],"issn-type":[{"value":"1551-7136","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Normal Hemodynamic Response to Exercise","name":"articletitle","label":"Article Title"},{"value":"Heart Failure Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hfc.2024.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}