{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:08:44Z","timestamp":1772140124205,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Failure Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.hfc.2025.09.001","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:48:40Z","timestamp":1763624920000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetics of Thoracic and Thoracoabdominal Aortic Dissections and Aneurysms"],"prefix":"10.1016","volume":"22","author":[{"given":"Jennifer L.","family":"Rios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Magee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hfc.2025.09.001_bib1","unstructured":"Milewicz D.M. and Cecchi A.C., Heritable thoracic aortic disease overview, In: Adam M.P., Feldman J., Mirzaa G.M., et al., GeneReviews\u00ae [Internet], 2003, University of Washington, Seattle; Seattle (WA), 1993\u20132024, Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1120\/ (Accessed 27 November 2024)."},{"issue":"5","key":"10.1016\/j.hfc.2025.09.001_bib2","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.athoracsur.2015.04.106","article-title":"Routine genetic testing for thoracic aortic aneurysm and dissection in a clinical setting","volume":"100","author":"Ziganshin","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.hfc.2025.09.001_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11606-012-1988-6","article-title":"The genetic information nondiscrimination act (GINA): public policy and medical practice in the age of personalized medicine","volume":"27","author":"Feldman","year":"2012","journal-title":"J Gen Intern Med"},{"issue":"3","key":"10.1016\/j.hfc.2025.09.001_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.23736\/S0021-9509.21.11816-6","article-title":"Update on the genetic risk for thoracic aortic aneurysms and acute aortic dissections: implications for clinical care","volume":"62","author":"Milewicz","year":"2021","journal-title":"J Cardiovasc Surg"},{"key":"10.1016\/j.hfc.2025.09.001_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J Med Genet"},{"key":"10.1016\/j.hfc.2025.09.001_bib6","unstructured":"Dietz H., FBN1-related marfan syndrome, In: Adam M.P., Feldman J., Mirzaa G.M., et al., GeneReviews\u00ae [Internet], 2001, University of Washington, Seattle; Seattle (WA), 1993\u20132024, Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1335\/ (Accessed 27 November 2024)."},{"issue":"6 Suppl","key":"10.1016\/j.hfc.2025.09.001_bib7","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jtcvs.2010.07.027","article-title":"Treatment guidelines for thoracic aortic aneurysms and dissections based on the underlying causative gene","volume":"140","author":"Milewicz","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.hfc.2025.09.001_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jacc.2018.04.089","article-title":"Clinical validity of genes for heritable thoracic aortic aneurysm and dissection","volume":"72","author":"Renard","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.hfc.2025.09.001_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/gim.2014.11","article-title":"Loeys-Dietz syndrome: a primer for diagnosis and management","volume":"16","author":"MacCarrick","year":"2014","journal-title":"Genet Med"},{"key":"10.1016\/j.hfc.2025.09.001_bib10","unstructured":"Loeys B.L. and Dietz H.C., Loeys-Dietz syndrome, In: Adam M.P., Feldman J., Mirzaa G.M., et al., GeneReviews\u00ae [Internet], 2008, University of Washington, Seattle; Seattle (WA), 1993\u20132024, Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1133\/ (Accessed 27 November 2024)."},{"issue":"8","key":"10.1016\/j.hfc.2025.09.001_bib11","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hfc.2025.09.001_bib12","unstructured":"Malfait F., Symoens S. and Syx D., Classic Ehlers-Danlos syndrome, In: Adam M.P., Feldman J., Mirzaa G.M., et al., GeneReviews\u00ae [Internet], 2007, University of Washington, Seattle; Seattle (WA), 1993\u20132024, Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1244\/ (Accessed 27 November 2024)."},{"key":"10.1016\/j.hfc.2025.09.001_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/ajmg.c.31548","article-title":"Ehlers-Danlos syndrome, classical type","volume":"175","author":"Bowen","year":"2017","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.hfc.2025.09.001_bib14","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"Vascular Ehlers-Danlos syndrome","author":"Byers","year":"1999"},{"issue":"8","key":"10.1016\/j.hfc.2025.09.001_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/GIM.0b013e3182180c89","article-title":"COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy","volume":"13","author":"Leistritz","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.hfc.2025.09.001_bib16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/gim.2014.72","article-title":"Survival is affected by mutation type and molecular mechanism in vascular Ehlers\u2013Danlos syndrome (EDS type IV)","volume":"16","author":"Pepin","year":"2014","journal-title":"Genet Med"},{"issue":"12","key":"10.1016\/j.hfc.2025.09.001_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/ejhg.2015.32","article-title":"The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome","volume":"23","author":"Frank","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"10","key":"10.1016\/j.hfc.2025.09.001_bib18","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"International registry of acute aortic dissection (IRAD) investigators. aortic diameter >or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the international registry of acute aortic dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.hfc.2025.09.001_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.semvascsurg.2022.02.005","article-title":"Aortic dissection collaborative. the mental health impact of aortic dissection","volume":"35","author":"Ilonzo","year":"2022","journal-title":"Semin Vasc Surg"}],"container-title":["Heart Failure Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551713625000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551713625000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:30:33Z","timestamp":1772137833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551713625000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1551713625000868"],"URL":"https:\/\/doi.org\/10.1016\/j.hfc.2025.09.001","relation":{},"ISSN":["1551-7136"],"issn-type":[{"value":"1551-7136","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetics of Thoracic and Thoracoabdominal Aortic Dissections and Aneurysms","name":"articletitle","label":"Article Title"},{"value":"Heart Failure Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hfc.2025.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}