{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:20:53Z","timestamp":1784996453508,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hellenic Journal of Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.hjc.2017.12.010","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T22:10:38Z","timestamp":1515017438000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of oral paricalcitol therapy on arterial stiffness and osteopontin in hypertensive patients with chronic kidney disease and secondary hyperparathyroidism"],"prefix":"10.1016","volume":"60","author":[{"given":"Michalis","family":"Giakoumis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Tsioufis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makro","family":"Sonikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Kasiakogias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Andrikou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-0391","authenticated-orcid":false,"given":"Theodoros","family":"Kalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-6401","authenticated-orcid":false,"given":"Dimitrios","family":"Konstantinidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Filis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Petras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tousoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hjc.2017.12.010_bib1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.hjc.2017.12.010_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.hjc.2017.12.010_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.hjc.2017.12.010_bib4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1681\/ASN.2004070573","article-title":"Activated injectable vitamin D and hemodialysis survival: A historical cohort study","volume":"16","author":"Teng","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.hjc.2017.12.010_bib5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJMoa022536","article-title":"Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy","volume":"349","author":"Teng","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.hjc.2017.12.010_bib6","first-page":"149","article-title":"The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection","volume":"8","author":"Duplancic","year":"2013","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.hjc.2017.12.010_bib7","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1046\/j.1523-1755.2003.00878.x","article-title":"Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism","volume":"63","author":"Sprague","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.hjc.2017.12.010_bib8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.ki.5002406","article-title":"Differential effects of vitamin D receptor activators on vascular calcification in uremic rats","volume":"72","author":"Mizobuchi","year":"2007","journal-title":"Kidney Int"},{"issue":"9","key":"10.1016\/j.hjc.2017.12.010_bib9","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/2012.jama.10503","article-title":"Aortic stiffness, blood pressure progression, and incident hypertension","volume":"308","author":"Kaess","year":"2012","journal-title":"JAMA"},{"issue":"18","key":"10.1016\/j.hjc.2017.12.010_bib10","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.jacc.2009.05.070","article-title":"High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study","volume":"54","author":"Roman","year":"2009","journal-title":"JACC"},{"issue":"3","key":"10.1016\/j.hjc.2017.12.010_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.HYP.38.3.434","article-title":"Arterial wave reflections and survival in end-stage renal failure","volume":"38","author":"London","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.hjc.2017.12.010_bib12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1681\/ASN.2006060573","article-title":"Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency","volume":"18","author":"London","year":"2007","journal-title":"J\u00a0Am Soc Nephrol: JASN"},{"issue":"5","key":"10.1016\/j.hjc.2017.12.010_bib13","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/01.HYP.0000185463.27209.b0","article-title":"Arterial stiffness is related to systemic inflammation in essential hypertension","volume":"46","author":"Mahmud","year":"2005","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.hjc.2017.12.010_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/10454411000110030101","article-title":"Osteopontin","volume":"11","author":"Sodek","year":"2000","journal-title":"Crit Rev Oral Biol Med"},{"issue":"11","key":"10.1016\/j.hjc.2017.12.010_bib15","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","article-title":"Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease","volume":"27","author":"Scatena","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.hjc.2017.12.010_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0021-9150(03)00298-3","article-title":"Plasma osteopontin levels are associated with the presence and extent of coronary artery disease","volume":"170","author":"Ohmori","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hjc.2017.12.010_bib17","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.ijcard.2012.05.001","article-title":"Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease","volume":"167","author":"Tousoulis","year":"2013","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.hjc.2017.12.010_bib18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2362.2010.02271.x","article-title":"Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease","volume":"40","author":"Lorenzen","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"10.1016\/j.hjc.2017.12.010_bib19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 Evidence-based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.hjc.2017.12.010_bib20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.jhh.1001115","article-title":"Absence of any significant effects of circadian blood pressure variations on carotid artery elastic properties in essential hypertensive subjects","volume":"14","author":"Tsioufis","year":"2000","journal-title":"J\u00a0Hum Hypertens"},{"key":"10.1016\/j.hjc.2017.12.010_bib21","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.hjc.2017.12.010_bib22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","article-title":"The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"25","author":"2007 Guidelines for the Management of Arterial Hypertension","year":"2007","journal-title":"J\u00a0Hypertens"},{"issue":"9","key":"10.1016\/j.hjc.2017.12.010_bib23","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1097\/01.hjh.0000174394.57644.69","article-title":"Left ventricular diastolic dysfunction is accompanied by increased aortic stiffness in the early stages of essential hypertension: a TDI approach","volume":"23","author":"Tsioufis","year":"2005","journal-title":"J\u00a0Hypertens"},{"issue":"5","key":"10.1016\/j.hjc.2017.12.010_bib24","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/HYPERTENSIONAHA.114.03748","article-title":"Paricalcitol and endothelial function in chronic kidney disease trial","volume":"64","author":"Zoccali","year":"2014","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.hjc.2017.12.010_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.hjc.2017.12.010_bib26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2362.2010.02257.x","article-title":"Osteopontin as a novel prognostic marker in stable ischaemic heart disease: a 3-year follow-up study","volume":"40","author":"Georgiadou","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"10.1016\/j.hjc.2017.12.010_bib27","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1159\/000321520","article-title":"Prognostic implication of plasma osteopontin levels in patients with chronic kidney disease","volume":"117","author":"Barreto","year":"2011","journal-title":"Nephron Clin Pract"},{"issue":"3","key":"10.1016\/j.hjc.2017.12.010_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jdiacomp.2015.01.004","article-title":"Effect of paricalcitol on endothelial function and inflammation in type 2 diabetes and chronic kidney disease","volume":"29","author":"Thethi","year":"2015","journal-title":"J\u00a0Diabet Complicat"},{"key":"10.1016\/j.hjc.2017.12.010_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jcph.19","article-title":"Anti-inflammatory profile of paricalcitol in hemodialysis patients: a prospective, open-label, pilot study","volume":"53","author":"Navarro-Gonz\u00e1lez","year":"2013","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.hjc.2017.12.010_bib30","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.hjc.2017.12.010_bib31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/jc.2014-3519","article-title":"Vitamin D and physical activity status: associations with five-year changes in body composition and muscle function in community-dwelling older adults","volume":"100","author":"Scott","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9752","key":"10.1016\/j.hjc.2017.12.010_bib32","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(10)61032-X","article-title":"Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial","volume":"376","author":"deZeeuw","year":"2011","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.hjc.2017.12.010_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000441364","article-title":"Paricalcitol, Microvascular and endothelial function in non-diabetic chronic kidney disease: a randomized trial","volume":"42","author":"Lundwall","year":"2015","journal-title":"Am J Nephrol"},{"issue":"4","key":"10.1016\/j.hjc.2017.12.010_bib34","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/ki.1994.380","article-title":"Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy","volume":"46","author":"Goodman","year":"1994","journal-title":"Kidney Int"},{"key":"10.1016\/j.hjc.2017.12.010_bib35","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1053\/ajkd.2001.29254","article-title":"Importance of low serum intact parathyroid hormone as a predictor of mortality in hemodialysis and peritoneal dialysis patients: 14 years of prospective observation","volume":"38","author":"Avram","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.hjc.2017.12.010_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.hjc.2016.04.002","article-title":"The impact of renal dysfunction on the outcome of patients with myocardial infarction: does gender really matter?","volume":"57","author":"Lazaros","year":"2016","journal-title":"Hellenic J Cardiol"},{"key":"10.1016\/j.hjc.2017.12.010_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.hjc.2015.11.001","article-title":"Gender differences in the prognostic impact of chronic kidney disease in patients with left ventricular systolic dysfunction following ST elevation myocardial infarction treated with primary percutaneous coronary intervention","volume":"57","author":"Savic","year":"2016","journal-title":"Hellenic J Cardiol"}],"container-title":["Hellenic Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1109966617305043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1109966617305043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:12:35Z","timestamp":1761099155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1109966617305043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1109966617305043"],"URL":"https:\/\/doi.org\/10.1016\/j.hjc.2017.12.010","relation":{},"ISSN":["1109-9666"],"issn-type":[{"value":"1109-9666","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of oral paricalcitol therapy on arterial stiffness and osteopontin in hypertensive patients with chronic kidney disease and secondary hyperparathyroidism","name":"articletitle","label":"Article Title"},{"value":"Hellenic Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hjc.2017.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}