{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:54:36Z","timestamp":1763348076553,"version":"3.40.5"},"reference-count":19,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["heartlungcirc.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart, Lung and Circulation"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.hlc.2016.12.011","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T11:45:39Z","timestamp":1486381539000},"page":"1113-1116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Early Experience of Macitentan for Pulmonary Arterial Hypertension in Adult Congenital Heart Disease"],"prefix":"10.1016","volume":"26","author":[{"given":"S.","family":"Herbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Gin-Sing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-6993","authenticated-orcid":false,"given":"R.M.R.","family":"Tulloh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hlc.2016.12.011_bib0005","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J Am Coll Cardiol"},{"year":"2015","series-title":"National Pulmonary Hypertension Audit\u20132014","author":"Health and Social Care Information Centre","key":"10.1016\/j.hlc.2016.12.011_bib0010"},{"key":"10.1016\/j.hlc.2016.12.011_bib0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.pathol.2.010506.092033","article-title":"Pathobiology of pulmonary hypertension","volume":"2","author":"Rabinovich","year":"2007","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.hlc.2016.12.011_bib0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1742-1241.2011.02823.x","article-title":"Management of Pulmonary Hypertension and Down\u2019s Syndrome","volume":"65","author":"King","year":"2011","journal-title":"Int J of Clin Pract"},{"key":"10.1016\/j.hlc.2016.12.011_bib0025","first-page":"1","article-title":"Treatment of pediatric pulmonary hypertension","volume":"5","author":"Hawkins","year":"2009","journal-title":"Vascular Health and Risk Management"},{"issue":"1","key":"10.1016\/j.hlc.2016.12.011_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"European Heart Journal"},{"issue":"6","key":"10.1016\/j.hlc.2016.12.011_bib0035","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1161\/01.CIR.84.6.2280","article-title":"Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation","volume":"84","author":"Yoshibayashi","year":"1991","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.hlc.2016.12.011_bib0040","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMra040291","article-title":"Treatment of pulmonary arterial hypertension","volume":"351","author":"Humbert","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hlc.2016.12.011_bib0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2004.08.025","article-title":"Safety and tolerability of bosentan in adults with Eisenmenger physiology","volume":"98","author":"Gatzoulis","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hlc.2016.12.011_bib0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","article-title":"Bosentan therapy in patients with Eisenmenger syndrome","volume":"114","author":"Gali\u00e8","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2016.12.011_bib0055","unstructured":"SmPC: Tracleer: http:\/\/www.medicines.org.uk\/emc\/. Accessed July 2016"},{"key":"10.1016\/j.hlc.2016.12.011_bib0060","unstructured":"SmPC: Opsumit: http:\/\/www.medicines.org.uk\/emc\/. Accessed July 2016"},{"issue":"10","key":"10.1016\/j.hlc.2016.12.011_bib0065","doi-asserted-by":"crossref","first-page":"e47662","DOI":"10.1371\/journal.pone.0047662","article-title":"Slow recpetor dissociation kinetics differentiate Macitentan from other endothelin receptor antagonists in Pulmonary arterial smooth muscle cells","volume":"7","author":"Gatfield","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.hlc.2016.12.011_bib0070","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1124\/jpet.108.142976","article-title":"Pharmacology of macitentan, an orally active tissue targeting dual endothelin receptor antagonist","volume":"327","author":"Iglarz","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.hlc.2016.12.011_bib0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1124\/jpet.114.214106","article-title":"Macitentan does not interfere with hepatic bile salt transport","volume":"350","author":"Treiber","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.hlc.2016.12.011_bib0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1517\/14740338.2014.859674","article-title":"Efficacy, safety and clinical pharmacology of Macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension","volume":"13","author":"Dingemanse","year":"2014","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.hlc.2016.12.011_bib0085","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1213917","article-title":"Macitentan and Morbidity and Mortality in Pulmonary arterial Hypertension","volume":"369","author":"Pulido","year":"2013","journal-title":"N Engl J Med"},{"issue":"10S","key":"10.1016\/j.hlc.2016.12.011_bib0090","doi-asserted-by":"crossref","first-page":"A564","DOI":"10.1016\/S0735-1097(15)60564-2","volume":"65","author":"Blok","year":"2015","journal-title":"JACC"},{"key":"10.1016\/j.hlc.2016.12.011_bib0095","unstructured":"ClinicalTrials.gov Identifier: NCT01743001"}],"container-title":["Heart, Lung and Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950617300318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950617300318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T06:34:46Z","timestamp":1529044486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1443950617300318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1443950617300318"],"URL":"https:\/\/doi.org\/10.1016\/j.hlc.2016.12.011","relation":{},"ISSN":["1443-9506"],"issn-type":[{"type":"print","value":"1443-9506"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Experience of Macitentan for Pulmonary Arterial Hypertension in Adult Congenital Heart Disease","name":"articletitle","label":"Article Title"},{"value":"Heart, Lung and Circulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hlc.2016.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}