{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:19:35Z","timestamp":1791883175297,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartlungcirc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart, Lung and Circulation"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.hlc.2024.09.012","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:27:16Z","timestamp":1748219236000},"page":"e89-e103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Functional Coronary Angiography for the Diagnosis of Coronary Vasomotor Disorders"],"prefix":"10.1016","volume":"34","author":[{"given":"Tom","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Zeitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2317-5213","authenticated-orcid":false,"given":"Jon","family":"Spiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-4300","authenticated-orcid":false,"given":"Andy","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Layland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Girolamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Marathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-2565","authenticated-orcid":false,"given":"Kazuaki","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Sidharta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-9923","authenticated-orcid":false,"given":"Kuljit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Tavella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-1451","authenticated-orcid":false,"given":"Omar","family":"Farouque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-780X","authenticated-orcid":false,"given":"Eng Lee","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarena","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrett K.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Montarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivabaskari","family":"Pasupathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Psaltis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmalar","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Rajwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Rehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-7890","authenticated-orcid":false,"given":"Abdul","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-4077","authenticated-orcid":false,"given":"Jithendra","family":"Somaratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Worthley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-6510","authenticated-orcid":false,"given":"John F.","family":"Beltrame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hlc.2024.09.012_bib1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.hlc.2024.09.012_bib2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.hlc.2024.09.012_bib3","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","article-title":"Low diagnostic yield of elective coronary angiography","volume":"362","author":"Patel","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hlc.2024.09.012_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008126","article-title":"Ischemia and no obstructive coronary artery disease: prevalence and correlates of coronary vasomotion disorders","volume":"12","author":"Ford","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade","volume":"135","author":"Bairey Merz","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2024.09.012_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-2796.2012.02591.x","article-title":"Assessing patients with myocardial infarction and non-obstructed coronary arteries (MINOCA)","volume":"273","author":"Beltrame","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.hlc.2024.09.012_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/heartjnl-2018-314661","article-title":"Angina: contemporary diagnosis and management","volume":"106","author":"Ford","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.hlc.2024.09.012_bib8","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jacc.2022.04.014","article-title":"Beyond Structural Angiography","volume":"79","author":"Beltrame","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib9","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.jacc.2018.09.006","article-title":"Stratified medical therapy using invasive coronary function testing in angina: the CorMicA Trial","volume":"72","author":"Ford","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijcard.2021.05.016","article-title":"Stratified medicine using invasive coronary function testing in angina: A cost-effectiveness analysis of the British Heart Foundation CorMicA trial","volume":"337","author":"Heggie","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib11","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib12","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Task Force","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib13","first-page":"284","article-title":"Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need","volume":"104","author":"Ford","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.hlc.2024.09.012_bib14","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.jacc.2017.09.016","article-title":"Sex-related differences in vasomotor function in patients with angina and unobstructed coronary arteries","volume":"70","author":"Aziz","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib15","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jcin.2015.06.017","article-title":"Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease","volume":"8","author":"Sara","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/cvr\/cvaa001","article-title":"Sex differences in non-obstructive coronary artery disease","volume":"116","author":"Waheed","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hlc.2024.09.012_bib17","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1093\/eurheartj\/ehab282","article-title":"Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group","volume":"42","author":"Shimokawa","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib18","first-page":"4788","article-title":"One-year outcomes of angina management guided by invasive coronary function testing (CorMicA)","author":"Ford","year":"2019","journal-title":"JACC: Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib19","first-page":"117","article-title":"Natural history of patients with insignificant coronary artery disease","volume":"2","author":"Tavella","year":"2016","journal-title":"Euro Heart J - QCCO"},{"key":"10.1016\/j.hlc.2024.09.012_bib20","first-page":"91","article-title":"Patients with acute myocardial infarction and non-obstructive coronary arteries: safety and prognostic relevance of invasive coronary provocative tests","volume":"39","author":"Montone","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib21","first-page":"e368","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"144","author":"Gulati","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2024.09.012_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/heartjnl-2022-321268","article-title":"Management of vasospastic angina","volume":"109","author":"Beltrame","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.hlc.2024.09.012_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.007889","article-title":"Prognostic value of coronary microvascular function measured immediately after percutaneous coronary intervention in stable coronary artery disease: an international multicenter study","volume":"12","author":"Nishi","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib24","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.jacc.2022.03.385","article-title":"Safety of provocative testing with intracoronary acetylcholine and implications for standard protocols","volume":"79","author":"Takahashi","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/HCV.0000000000000035","article-title":"An update on radial artery access and best practices for transradial coronary angiography and intervention in acute coronary syndrome: a scientific statement from the American Heart Association","volume":"11","author":"Mason","year":"2018","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib26","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.jcin.2020.05.052","article-title":"Assessment of vascular dysfunction in patients without obstructive coronary artery disease: why, how, and when","volume":"13","author":"Ford","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib27","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jcin.2024.03.007","article-title":"Multivessel coronary function testing increases diagnostic yield in patients with angina and nonobstructive coronary arteries","volume":"17","author":"Rehan","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jcin.2022.03.015","article-title":"Comparison of Doppler flow velocity and thermodilution derived indexes of coronary physiology","volume":"15","author":"Demir","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0735-1097(88)90449-4","article-title":"Sensitivity and specificity of intracoronary injection of acetylcholine for the induction of coronary artery spasm","volume":"12","author":"Okumura","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib30","first-page":"2565","article-title":"International standardization of diagnostic criteria for vasospastic angina","volume":"38","author":"Beltrame","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","article-title":"International standardization of diagnostic criteria for microvascular angina","volume":"250","author":"Ong","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2169\/internalmedicine.1483-18","article-title":"Catheter-induced spasm in the proximal right coronary artery","volume":"58","author":"Sueda","year":"2019","journal-title":"Intern Med"},{"key":"10.1016\/j.hlc.2024.09.012_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/1744-1609.12002","article-title":"Chest pain in patients with 'normal angiography': could it be cardiac?","volume":"11","author":"Di Fiore","year":"2013","journal-title":"Int J Evid Based Healthc"},{"key":"10.1016\/j.hlc.2024.09.012_bib34","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1093\/eurheartj\/ehu427","article-title":"2014 William Harvey Lecture: importance of coronary vasomotion abnormalities-from bench to bedside","volume":"35","author":"Shimokawa","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2024.09.012_bib35","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1253\/circj.CJ-66-0098","article-title":"Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina) (JCS 2013)","volume":"78","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.hlc.2024.09.012_bib36","article-title":"Management of ischaemia with non-obstructive coronary arteries (INOCA)","volume":"375","author":"Beltrame","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.hlc.2024.09.012_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.78.1.1","article-title":"Long-term prognosis for patients with variant angina and influential factors","volume":"78","author":"Yasue","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2024.09.012_bib38","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0002-9149(99)00450-6","article-title":"Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X","volume":"84","author":"Lanza","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib39","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1016\/j.jcin.2023.09.027","article-title":"Continuous vs bolus thermodilution to assess microvascular resistance reserve","volume":"16","author":"Gallinoro","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hlc.2024.09.012_bib40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030480","article-title":"Continuous versus bolus thermodilution-derived coronary flow reserve and microvascular resistance reserve and their association with angina and quality of life in patients with angina and nonobstructive coronaries: a head-to-head comparison","volume":"12","author":"Jansen","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hlc.2024.09.012_bib44","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amjcard.2017.09.012","article-title":"Doppler versus thermodilution-derived coronary microvascular resistance to predict coronary microvascular dysfunction in patients with acute myocardial infarction or stable angina pectoris","volume":"121","author":"Williams","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hlc.2024.09.012_bib43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/jcm11010228","article-title":"Invasive assessment of coronary microvascular function","volume":"11","author":"Mangiacapra","year":"2021","journal-title":"J Clin Med"}],"container-title":["Heart, Lung and Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950625004068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950625004068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:53:42Z","timestamp":1757120022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1443950625004068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1443950625004068"],"URL":"https:\/\/doi.org\/10.1016\/j.hlc.2024.09.012","relation":{},"ISSN":["1443-9506"],"issn-type":[{"value":"1443-9506","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Coronary Angiography for the Diagnosis of Coronary Vasomotor Disorders","name":"articletitle","label":"Article Title"},{"value":"Heart, Lung and Circulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hlc.2024.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).","name":"copyright","label":"Copyright"}]}}