{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:22:51Z","timestamp":1774002171304,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008810","name":"New South Wales Ministry of Health","doi-asserted-by":"publisher","award":["H22\/4011"],"award-info":[{"award-number":["H22\/4011"]}],"id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2007970"],"award-info":[{"award-number":["2007970"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["APP105721"],"award-info":[{"award-number":["APP105721"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartlungcirc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart, Lung and Circulation"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.hlc.2025.09.013","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:35:29Z","timestamp":1773347729000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Barriers and Facilitators to Implementing Guideline Recommendations for Key Aspects of Familial Hypercholesterolemia Management in Australia: Primary Care Integration, Paediatric Management, and Treatment Adherence"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-3598","authenticated-orcid":false,"given":"Mitchell","family":"Sarkies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo-Anne","family":"Manski-Nankervis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubha","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9474-258X","authenticated-orcid":false,"given":"Natalie","family":"Raffoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Mazariego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Carrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-9138","authenticated-orcid":false,"given":"Cameron","family":"Hemmert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-5627","authenticated-orcid":false,"given":"David","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-0488","authenticated-orcid":false,"given":"Jan","family":"Radford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-4343","authenticated-orcid":false,"given":"Ari","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-8976","authenticated-orcid":false,"given":"Stephanie","family":"Best","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna C.","family":"Moullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-6948","authenticated-orcid":false,"given":"Jing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Braithwaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-1524","authenticated-orcid":false,"given":"Gerald F.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hlc.2025.09.013_bib1","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.jacc.2020.03.057","article-title":"Worldwide prevalence of familial hypercholesterolemia: meta-analyses of 11 million subjects","volume":"75","author":"Beheshti","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib2","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1161\/ATVBAHA.121.316862","article-title":"What is the prevalence of familial hypercholesterolemia?","volume":"41","author":"Brunham","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.hlc.2025.09.013_bib3","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/CIRCULATIONAHA.119.044795","article-title":"Prevalence of familial hypercholesterolemia among the general population and patients with atherosclerotic cardiovascular disease: A systematic review and meta-analysis","volume":"141","author":"Hu","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2025.09.013_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCGEN.122.003842","article-title":"Enhancing the detection and care of heterozygous familial hypercholesterolemia in primary care: cost-effectiveness and return on investment","volume":"16","author":"Marquina","year":"2023","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.hlc.2025.09.013_bib5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.hlc.2019.12.002","article-title":"Familial hypercholesterolaemia in 2020: A leading Tier 1 genomic application","volume":"29","author":"Pang","year":"2020","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hlc.2025.09.013_bib6","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1093\/eurheartj\/eht273","article-title":"Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society","volume":"34","author":"Nordestgaard","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2025.09.013_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jacl.2021.01.008","article-title":"Closing the gap: identification and management of familial hypercholesterolemia in an integrated healthcare delivery system","volume":"15","author":"Birnbaum","year":"2021","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.hlc.2025.09.013_bib8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.hlc.2020.07.012","article-title":"Gaps in the care of familial hypercholesterolaemia in Australia: first report from the National registry","volume":"30","author":"Pang","year":"2021","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hlc.2025.09.013_bib9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.atherosclerosis.2018.08.051","article-title":"Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)","volume":"277","author":"Vallejo-Vaz","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hlc.2025.09.013_bib10","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0140-6736(21)01122-3","article-title":"Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)","volume":"398","author":"Vallejo-Vaz","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.hlc.2025.09.013_bib11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/jpm12040606","article-title":"Collaborative approach to reach everyone with familial hypercholesterolemia: CARE-FH protocol","volume":"12","author":"Jones","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.hlc.2025.09.013_bib12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.hlc.2020.09.943","article-title":"Integrated guidance for enhancing the care of familial hypercholesterolaemia in Australia","volume":"30","author":"Watts","year":"2021","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hlc.2025.09.013_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2021.100151","article-title":"Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective","volume":"6","author":"Watts","year":"2021","journal-title":"Am J Prev Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/imj.15327","article-title":"Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians","volume":"51","author":"Watts","year":"2021","journal-title":"Intern Med J"},{"key":"10.1016\/j.hlc.2025.09.013_bib15","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/jpc.16096","article-title":"Integrated guidance to enhance the care of children and adolescents with familial hypercholesterolaemia: practical advice for the community clinician","volume":"58","author":"Horton","year":"2022","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.hlc.2025.09.013_bib16","series-title":"National health genomics policy framework 2018\u20132021. Implementation Plan","year":"2019"},{"key":"10.1016\/j.hlc.2025.09.013_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41569-021-00645-x","article-title":"Improving clinical practice guidelines with implementation science","volume":"19","author":"Sarkies","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib18","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1108\/JHOM-02-2021-0056","article-title":"Understanding implementation science from the standpoint of health organisation and management: an interdisciplinary exploration of selected theories, models and frameworks","volume":"35","author":"Sarkies","year":"2021","journal-title":"JHOM"},{"key":"10.1016\/j.hlc.2025.09.013_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003833","article-title":"Effectiveness of knowledge brokering and recommendation dissemination for influencing healthcare resource allocation decisions: A cluster randomised controlled implementation trial","volume":"18","author":"Sarkies","year":"2021","journal-title":"PLOS Med"},{"key":"10.1016\/j.hlc.2025.09.013_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12874-022-01661-2","article-title":"Making implementation science more real","volume":"22","author":"Sarkies","year":"2022","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.hlc.2025.09.013_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1748-5908-9-54","article-title":"Applications of social constructivist learning theories in knowledge translation for healthcare professionals: a scoping review","volume":"9","author":"Thomas","year":"2014","journal-title":"Implement Sci"},{"key":"10.1016\/j.hlc.2025.09.013_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/bmj.311.7000.299","article-title":"Qualitative research: introducing focus groups","volume":"311","author":"Kitzinger","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.hlc.2025.09.013_bib23","series-title":"Focus Groups as Qualitative Research","author":"Morgan","year":"1997"},{"key":"10.1016\/j.hlc.2025.09.013_bib24","series-title":"Version","article-title":"NVivo qualitative data analysis.","volume":"12","year":"2018"},{"key":"10.1016\/j.hlc.2025.09.013_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/160940690600500107","article-title":"Demonstrating rigor using thematic analysis: A hybrid approach of inductive and deductive coding and theme development","volume":"5","author":"Fereday","year":"2006","journal-title":"Int J Qual Methods"},{"key":"10.1016\/j.hlc.2025.09.013_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244193","article-title":"Barriers, facilitators, and solutions to familial hypercholesterolemia treatment","volume":"15","author":"Jones","year":"2020","journal-title":"PLOS One"},{"key":"10.1016\/j.hlc.2025.09.013_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/VHRM.S192401","article-title":"Barriers to early diagnosis and treatment of familial hypercholesterolemia: current perspectives on improving patient care","volume":"16","author":"Alonso","year":"2020","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.hlc.2025.09.013_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jacl.2019.10.005","article-title":"Long-term effect of 2 intensive statin regimens on treatment and incidence of cardiovascular events in familial hypercholesterolemia: the SAFEHEART study","volume":"13","author":"P\u00e9rez de Isla","year":"2019","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.hlc.2025.09.013_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.atherosclerosis.2019.05.003","article-title":"Potential utility of the SAFEHEART risk equation for rationalising the use of PCSK9 monoclonal antibodies in adults with heterozygous familial hypercholesterolemia","volume":"286","author":"P\u00e9rez de Isla","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hlc.2025.09.013_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2022.100344","article-title":"Patient experiences align with the familial hypercholesterolemia global call to action","volume":"10","author":"Jones","year":"2022","journal-title":"Am J Prev Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib31","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/eurheartj\/ehx549","article-title":"2017 Update of ESC\/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin\/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia","volume":"39","author":"Landmesser","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2025.09.013_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MOL.0000000000000553","article-title":"Atherosclerotic cardiovascular disease risk assessment in familial hypercholesterolemia: does one size fit all?","volume":"29","author":"Mata","year":"2018","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.hlc.2025.09.013_bib33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.atherosclerosis.2018.08.020","article-title":"Familial hypercholesterolaemia patient support groups and advocacy: a multinational perspective","volume":"277","author":"Payne","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hlc.2025.09.013_bib34","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1161\/CIRCULATIONAHA.116.024541","article-title":"Predicting cardiovascular events in familial hypercholesterolemia: the SAFEHEART registry (Spanish Familial hypercholesterolemia Cohort Study)","volume":"135","author":"P\u00e9rez de Isla","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2025.09.013_bib35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s43058-024-00670-0","article-title":"A qualitative study of perceptions of the care pathway for familial hypercholesterolemia: screening, diagnosis, treatment, and family cascade screening","volume":"5","author":"Pettit","year":"2024","journal-title":"Implement Sci Commun"},{"key":"10.1016\/j.hlc.2025.09.013_bib36","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S2213-8587(16)30041-9","article-title":"Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel","volume":"4","author":"Santos","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.hlc.2025.09.013_bib37","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1161\/01.CIR.0000041253.61683.08","article-title":"Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population","volume":"106","author":"Umans-Eckenhausen","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2025.09.013_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jamacardio.2019.5173","article-title":"Reducing the clinical and public health burden of familial hypercholesterolemia: a global call to action","volume":"5","author":"Wilemon","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2019.06.900","article-title":"Economic evaluation of lipid lowering with PCSK9 inhibitors in patients with familial hypercholesterolemia: methodological aspects","volume":"287","author":"Wisl\u00f8ff","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.hlc.2025.09.013_bib40","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41569-023-00892-0","article-title":"International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia","volume":"20","author":"Watts","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hlc.2025.09.013_bib41","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jacl.2025.03.004","article-title":"Developing a national implementation strategy for enhancing the detection of familial hypercholesterolemia: an Australian experience","volume":"19","author":"Sarkies","year":"2025","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.hlc.2025.09.013_bib44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5694\/mja2.51454","article-title":"Population DNA screening for medically actionable disease risk in adults","volume":"216","author":"Lacaze","year":"2022","journal-title":"Med J Aust"},{"key":"10.1016\/j.hlc.2025.09.013_bib45","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/clinchem\/hvad066","article-title":"Feasibility of targeted next-generation DNA sequencing for expanding population newborn screening","volume":"69","author":"Shum","year":"2023","journal-title":"Clin Chem"}],"container-title":["Heart, Lung and Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950625016919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950625016919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:44:35Z","timestamp":1773992675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1443950625016919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":43,"alternative-id":["S1443950625016919"],"URL":"https:\/\/doi.org\/10.1016\/j.hlc.2025.09.013","relation":{},"ISSN":["1443-9506"],"issn-type":[{"value":"1443-9506","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Barriers and Facilitators to Implementing Guideline Recommendations for Key Aspects of Familial Hypercholesterolemia Management in Australia: Primary Care Integration, Paediatric Management, and Treatment Adherence","name":"articletitle","label":"Article Title"},{"value":"Heart, Lung and Circulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hlc.2025.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).","name":"copyright","label":"Copyright"}]}}