{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:17:14Z","timestamp":1788304634129,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartlungcirc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart, Lung and Circulation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hlc.2026.03.070","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:38:17Z","timestamp":1782992297000},"page":"1259-1270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meta-Analysis of Randomised Controlled Trials on the Efficacy of Direct Oral Anticoagulants in Left Ventricular Thrombosis: An Updated Perspective"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2792-7076","authenticated-orcid":false,"given":"Bernardo","family":"Resende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-1057","authenticated-orcid":false,"given":"Mariana","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-3690","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Ferraz-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-3491","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hlc.2026.03.070_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/heartjnl-2024-324605","article-title":"Advancing clinical management of left ventricular thrombosis: prevention, detection and treatment modalities in the modern era","volume":"111","author":"Zhang","year":"2025","journal-title":"Heart"},{"key":"10.1016\/j.hlc.2026.03.070_bib2","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2026.03.070_bib3","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.jacc.2019.01.031","article-title":"Left ventricular thrombus: contemporary etiologies, treatment strategies, and outcomes","volume":"73","author":"McCarthy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib4","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jacc.2022.01.011","article-title":"Left ventricular thrombus following acute myocardial infarction: JACC state-of-the-art review","volume":"79","author":"Camaj","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ijcard.2016.07.069","article-title":"Left ventricular thrombi after STEMI in the primary PCI era: A systematic review and meta-analysis","volume":"221","author":"Robinson","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12968-018-0494-3","article-title":"Incidence and predictors of left ventricular thrombus by cardiovascular magnetic resonance in acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: a meta-analysis","volume":"20","author":"Bulluck","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.hlc.2026.03.070_bib7","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hlc.2026.03.070_bib8","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.hlc.2026.03.070_bib9","article-title":"Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation","volume":"3","author":"Bruins Slot","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hlc.2026.03.070_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017559","article-title":"Direct oral anticoagulant use: a practical guide to common clinical challenges","volume":"9","author":"Chen","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hlc.2026.03.070_bib11","doi-asserted-by":"crossref","DOI":"10.15420\/cfr.2022.28","article-title":"Treatment of persistent left atrial appendage thrombus in patients with atrial fibrillation on adequate oral anticoagulation: pathways of care for all-comers and heart failure patients","volume":"9","author":"Katic","year":"2023","journal-title":"Card Fail Rev"},{"key":"10.1016\/j.hlc.2026.03.070_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1074248420977567","article-title":"Left ventricular thrombus therapy with direct oral anticoagulants versus vitamin K antagonists: a systematic review and meta-analysis","volume":"26","author":"Saleiro","year":"2021","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.hlc.2026.03.070_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.amjcard.2024.09.008","article-title":"Direct oral anticoagulants versus vitamin K antagonists for the management of left ventricular thrombus after myocardial infarction: a meta-analysis","volume":"232","author":"Gogos","year":"2024","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib14","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/FJC.0000000000001270","article-title":"Direct oral anticoagulants versus vitamin K antagonists for the treatment of left ventricular thrombus: an updated meta-analysis of cohort studies and randomized controlled trials","volume":"79","author":"Chen","year":"2022","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hlc.2026.03.070_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.carrev.2021.03.001","article-title":"Meta-analysis of direct oral anticoagulants compared with vitamin K antagonist for left ventricle thrombus","volume":"35","author":"Mir","year":"2021","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.hlc.2026.03.070_bib16","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1111\/jce.15016","article-title":"Direct oral anticoagulants to treat left ventricular thrombus-A systematic review and meta-analysis: ELECTRAM investigators","volume":"32","author":"Shah","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12959-021-00259-w","article-title":"Warfarin versus direct oral anticoagulants for treating left ventricular thrombus: a systematic review and meta-analysis","volume":"19","author":"Dalia","year":"2021","journal-title":"Thromb J"},{"key":"10.1016\/j.hlc.2026.03.070_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/MCA.0000000000001230","article-title":"An evidence-based evaluation of left ventricular thrombus treatment, outcomes, and resolution: a systematic review, pooled analysis and meta-analysis","volume":"34","author":"Kwok","year":"2023","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.hlc.2026.03.070_bib19","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jacc.2021.01.049","article-title":"Comparative study of oral anticoagulation in left ventricular thrombi (No-LVT trial)","volume":"77","author":"Abdelnabi","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.101978","article-title":"Rivaroxaban vs warfarin in acute left ventricular thrombus following myocardial infarction: RIVAWAR, an open-label RCT","volume":"4","author":"Shah","year":"2025","journal-title":"JACC Adv"},{"key":"10.1016\/j.hlc.2026.03.070_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/JCPC.JCPC_41_20","article-title":"Apixaban versus warfarin in patients with left ventricular thrombus: a pilot prospective randomized outcome blinded study investigating size reduction or resolution of left ventricular thrombus","volume":"9","author":"Isa","year":"2020","journal-title":"J Clin Prev Cardiol"},{"key":"10.1016\/j.hlc.2026.03.070_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cjco.2022.12.003","article-title":"Apixaban in patients with post-myocardial infarction left ventricular thrombus: a randomized clinical trial","volume":"5","author":"Youssef","year":"2023","journal-title":"CJC Open"},{"key":"10.1016\/j.hlc.2026.03.070_bib23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/ehjcvp\/pvab057","article-title":"Apixaban vs. warfarin in patients with left ventricular thrombus: a prospective multicentre randomized clinical trial\u2021","volume":"8","author":"Alcalai","year":"2022","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.hlc.2026.03.070_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4244\/EIJ-D-24-00527","article-title":"Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials","volume":"21","author":"Jenab","year":"2025","journal-title":"EuroIntervention"},{"key":"10.1016\/j.hlc.2026.03.070_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12959-024-00632-5","article-title":"Evaluation of the efficacy and safety of Rivaroxaban compared to warfarin in patients with left ventricular apical thrombus: a randomized clinical trial","volume":"22","author":"Mansouri","year":"2024","journal-title":"Thromb J"},{"key":"10.1016\/j.hlc.2026.03.070_bib26","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hlc.2026.03.070_bib27","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in Patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hlc.2026.03.070_bib28","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in Patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hlc.2026.03.070_bib29","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1161\/CIRCULATIONAHA.121.054990","article-title":"Apixaban for patients with atrial fibrillation on hemodialysis: a multicenter randomized controlled trial","volume":"146","author":"Pokorney","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2026.03.070_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.122.062779","article-title":"A randomized controlled trial comparing apixaban with the vitamin K antagonist phenprocoumon in patients on chronic hemodialysis: the AXADIA-AFNET 8 study","volume":"147","author":"Reinecke","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.hlc.2026.03.070_bib31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.21037\/atm.2020.02.117","article-title":"Rationale and design of a prospective multi-center randomized trial of EARLY treatment by Rivaroxaban versus warfarin in ST-segment elevation myocardial infarction with Left ventricular Thrombus (EARLY-MYO-LVT trial)","volume":"8","author":"He","year":"2020","journal-title":"Ann Transl Med"}],"container-title":["Heart, Lung and Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950626002222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1443950626002222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:55:21Z","timestamp":1788303321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1443950626002222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1443950626002222"],"URL":"https:\/\/doi.org\/10.1016\/j.hlc.2026.03.070","relation":{},"ISSN":["1443-9506"],"issn-type":[{"value":"1443-9506","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-Analysis of Randomised Controlled Trials on the Efficacy of Direct Oral Anticoagulants in Left Ventricular Thrombosis: An Updated Perspective","name":"articletitle","label":"Article Title"},{"value":"Heart, Lung and Circulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hlc.2026.03.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}