{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:24:25Z","timestamp":1787181865999,"version":"build-2736575974"},"reference-count":7,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA1309200"],"award-info":[{"award-number":["2025YFA1309200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2306204"],"award-info":[{"award-number":["2023YFC2306204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82595923"],"award-info":[{"award-number":["82595923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20654"],"award-info":[{"award-number":["U25A20654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92569301"],"award-info":[{"award-number":["92569301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000148","name":"Canadian Anesthesiologists' Society","doi-asserted-by":"publisher","award":["YSBR-010"],"award-info":[{"award-number":["YSBR-010"]}],"id":[{"id":"10.13039\/501100000148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["JQ24043"],"award-info":[{"award-number":["JQ24043"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["hLife"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.hlife.2026.05.005","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:25:14Z","timestamp":1779726314000},"page":"463-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["New design for universal respiratory vaccines: A new paradigm on integrated immunity"],"prefix":"10.1016","volume":"4","author":[{"given":"Zhen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-3386","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hlife.2026.05.005_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.chom.2022.11.016","article-title":"Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses","volume":"31","author":"Morens","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.hlife.2026.05.005_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.hlife.2026.05.005_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/science.aea1260","article-title":"Mucosal vaccination in mice provides protection from diverse respiratory threats","volume":"392","author":"Zhang","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.hlife.2026.05.005_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41577-024-00990-1","article-title":"Integrated organ immunity: A path to a universal vaccine","volume":"24","author":"Pulendran","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.hlife.2026.05.005_bib5","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1016\/j.cell.2024.07.021","article-title":"Transforming vaccinology","volume":"187","author":"Rappuoli","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.hlife.2026.05.005_bib6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41590-023-01739-z","article-title":"BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-\u03b3-mediated trained immunity","volume":"25","author":"Tran","year":"2024","journal-title":"Nat Immunol"},{"key":"10.1016\/j.hlife.2026.05.005_bib7","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1016\/j.cell.2021.05.039","article-title":"The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination","volume":"184","author":"Wimmers","year":"2021","journal-title":"Cell"}],"container-title":["hLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949928326000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949928326000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:42:36Z","timestamp":1787179356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949928326000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2949928326000337"],"URL":"https:\/\/doi.org\/10.1016\/j.hlife.2026.05.005","relation":{},"ISSN":["2949-9283"],"issn-type":[{"value":"2949-9283","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New design for universal respiratory vaccines: A new paradigm on integrated immunity","name":"articletitle","label":"Article Title"},{"value":"hLife","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hlife.2026.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Institute of Microbiology, Chinese Academy of Sciences.","name":"copyright","label":"Copyright"}]}}