{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:19:43Z","timestamp":1790493583271,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.hoc.2009.04.009","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T05:35:30Z","timestamp":1246599330000},"page":"655-674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":169,"title":["Acute Lymphoblastic Leukemia"],"prefix":"10.1016","volume":"23","author":[{"given":"Mihaela","family":"Onciu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hoc.2009.04.009_bib1","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"157","year":"2008"},{"key":"10.1016\/j.hoc.2009.04.009_bib2","unstructured":"National Cancer Institute. SEER Cancer Statistics Review, 1975\u20132006. Available at: http:\/\/seer.cancer.gov\/csr\/1975_2006\/. Accessed January 23, 2009."},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib3","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-F","article-title":"Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type","volume":"75","author":"Gurney","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.hoc.2009.04.009_bib4","author":"American Cancer Society"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/annonc\/mdn182","article-title":"Biologic features and treatment outcome of secondary acute lymphoblastic leukemia\u2013a review of 101 cases","volume":"19","author":"Shivakumar","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.hoc.2009.04.009_bib6","series-title":"Childhood leukemias","first-page":"48","article-title":"Epidemiology and etiology","author":"Spector","year":"2006"},{"issue":"25","key":"10.1016\/j.hoc.2009.04.009_bib7","doi-asserted-by":"crossref","first-page":"13950","DOI":"10.1073\/pnas.94.25.13950","article-title":"Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots","volume":"94","author":"Gale","year":"1997","journal-title":"Proc Natl Acad Sci U\u00a0S A"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib8","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1182\/blood.V99.8.2992","article-title":"High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia","volume":"99","author":"Taub","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.04.009_bib9","series-title":"Childhood leukemias","first-page":"439","article-title":"Acute lymphoblastic leukemia","author":"Pui","year":"2006"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10024-001-0104-4","article-title":"Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor B-cell lineage","volume":"5","author":"Kahwash","year":"2002","journal-title":"Pediatr Dev Pathol"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","article-title":"Proposals for the classification of the acute leukaemias. French- American-British (FAB) co-operative group","volume":"33","author":"Bennett","year":"1976","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2141.1981.tb02684.x","article-title":"The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations","volume":"47","author":"Bennett","year":"1981","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib13","first-page":"1048","article-title":"Bone marrow reticulin fiber deposition in pediatric patients with acute lymphoblastic leukemia","volume":"15","author":"Lorsbach","year":"2002","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2141.1988.tb02461.x","article-title":"Blast cell vacuoles in childhood lymphoblastic leukaemia","volume":"70","author":"Lilleyman","year":"1988","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/jcp.40.3.251","article-title":"Granular acute lymphoblastic leukaemia of childhood: a morphological phenomenon","volume":"40","author":"Darbyshire","year":"1987","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib16","first-page":"207","article-title":"Anomalous azurophilic granules in acute lymphoblastic leukemia","volume":"4","author":"Dyment","year":"1982","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ajcp\/79.4.426","article-title":"Granular acute lymphoblastic leukemia","volume":"79","author":"Stein","year":"1983","journal-title":"Am J\u00a0Clin Pathol"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib18","first-page":"485","article-title":"Acute lymphoblastic leukaemia with giant intracytoplasmic inclusions\u2013a case report","volume":"43","author":"Sharma","year":"2000","journal-title":"Indian J Pathol Microbiol"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ajcp\/74.3.345","article-title":"Acute lymphoblastic leukemia with giant intracytoplasmic inclusions","volume":"74","author":"Yanagihara","year":"1980","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ajh.2830070103","article-title":"Acute lymphoblastic leukemia\u2013hand mirror variant. An analysis of a large group of patients","volume":"7","author":"Schumacher","year":"1979","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00380-004-0786-4","article-title":"Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia","volume":"20","author":"Horigome","year":"2005","journal-title":"Heart Vessels"},{"key":"10.1016\/j.hoc.2009.04.009_bib22","series-title":"Acute leukemias. Tumors of the bone marrow","author":"Brunning","year":"1994"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2141.1989.tb07745.x","article-title":"Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of eight cases","volume":"73","author":"Cantu-Rajnoldi","year":"1989","journal-title":"Br J Haematol"},{"issue":"10","key":"10.1016\/j.hoc.2009.04.009_bib24","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.5858\/2003-127-1340-IBALLW","article-title":"Is B-lineage acute lymphoblastic leukemia with a mature phenotype and l1 morphology a precursor B-lymphoblastic leukemia\/lymphoma or Burkitt leukemia\/lymphoma?","volume":"127","author":"Li","year":"2003","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"10.1016\/j.hoc.2009.04.009_bib25","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1080\/10428190500473238","article-title":"Surface immunoglobulin positive lymphoblastic leukemia in adults; a genetic spectrum","volume":"47","author":"Nelson","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"10.1016\/j.hoc.2009.04.009_bib26","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<140::AID-PATH149>3.0.CO;2-Y","article-title":"Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma","volume":"186","author":"Pilozzi","year":"1998","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5858\/2000-124-0092-TDTNAL","article-title":"Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia","volume":"124","author":"Faber","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.hoc.2009.04.009_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Coustan-Smith","year":"2009","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.hoc.2009.04.009_bib30","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/cncr.11664","article-title":"The biology and therapy of adult acute lymphoblastic leukemia","volume":"98","author":"Faderl","year":"2003","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib31","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1182\/blood-2004-07-2922","article-title":"A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol","volume":"105","author":"Mancini","year":"2005","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib32","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1182\/blood-2003-01-0338","article-title":"Classification of pediatric acute lymphoblastic leukemia by gene expression profiling","volume":"102","author":"Ross","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1535-6108(02)00032-6","article-title":"Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling","volume":"1","author":"Yeoh","year":"2002","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.hoc.2009.04.009_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1470-2045(01)00516-2","article-title":"Childhood acute lymphoblastic leukaemia\u2013current status and future perspectives","volume":"2","author":"Pui","year":"2001","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib35","first-page":"1094","article-title":"TEL\/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia","volume":"96","author":"Ramakers-van Woerden","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib36","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1182\/blood-2002-05-1600","article-title":"Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia","volume":"101","author":"Stam","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1172\/JCI22477","article-title":"Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics","volume":"115","author":"Kager","year":"2005","journal-title":"J Clin Invest"},{"issue":"7137","key":"10.1016\/j.hoc.2009.04.009_bib38","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ng765","article-title":"MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia","volume":"30","author":"Armstrong","year":"2002","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib40","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1182\/blood-2003-07-2441","article-title":"FLT3 mutations in childhood acute lymphoblastic leukemia","volume":"103","author":"Armstrong","year":"2004","journal-title":"Blood"},{"issue":"7191","key":"10.1016\/j.hoc.2009.04.009_bib41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature06866","article-title":"BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros","volume":"453","author":"Mullighan","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1182\/blood-2003-02-0418","article-title":"FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy","volume":"103","author":"Taketani","year":"2004","journal-title":"Blood"},{"issue":"5015","key":"10.1016\/j.hoc.2009.04.009_bib43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1676542","article-title":"Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia","volume":"253","author":"Hatano","year":"1991","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.hoc.2009.04.009_bib44","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1073\/pnas.88.20.8900","article-title":"HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24","volume":"88","author":"Kennedy","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib45","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1182\/blood-2001-11-0093","article-title":"HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis","volume":"100","author":"Ballerini","year":"2002","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.hoc.2009.04.009_bib46","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/sj.leu.2402249","article-title":"A new recurrent and specific cryptic translocation, t(5;14) (q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia","volume":"15","author":"Bernard","year":"2001","journal-title":"Leukemia"},{"issue":"24","key":"10.1016\/j.hoc.2009.04.009_bib47","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1038\/sj.onc.1202353","article-title":"The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14) (p15;q11)","volume":"17","author":"Valge-Archer","year":"1998","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.leu.2401629","article-title":"Identification and molecular characterization of CALM\/AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia","volume":"14","author":"Carlson","year":"2000","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib49","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1046\/j.1365-2141.1999.01433.x","article-title":"Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11) (p13;q14) and identification of novel transcripts","volume":"105","author":"Narita","year":"1999","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib50","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood-2002-09-2913","article-title":"CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage","volume":"102","author":"Asnafi","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib51","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/sj.leu.2405074","article-title":"The role of CALM-AF10 gene fusion in acute leukemia","volume":"22","author":"Caudell","year":"2008","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia","volume":"1","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib53","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/sj.leu.2404302","article-title":"Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast","volume":"20","author":"Graux","year":"2006","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.hoc.2009.04.009_bib54","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/sj.leu.2402892","article-title":"Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG)","volume":"17","author":"Kees","year":"2003","journal-title":"Leukemia"},{"issue":"5694","key":"10.1016\/j.hoc.2009.04.009_bib55","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.hoc.2009.04.009_bib56","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1182\/blood-2003-11-3944","article-title":"Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy","volume":"104","author":"Asnafi","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.leu.2401277","article-title":"Cross-lineage T\u00a0cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease","volume":"13","author":"Szczepanski","year":"1999","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.hoc.2009.04.009_bib58","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/sj.leu.2403505","article-title":"TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse","volume":"18","author":"van der Velden","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.hoc.2009.04.009_bib59","series-title":"Childhood leukemias","first-page":"210","article-title":"Immunoglobulin and T-cell receptor gene rearrangements","author":"van Dongen","year":"2006"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib60","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.4049\/jimmunol.159.9.4341","article-title":"Human T cell leukemias with continuous V(D)J recombinase activity for TCR-delta gene deletion","volume":"159","author":"Breit","year":"1997","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib61","first-page":"657","article-title":"Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin","volume":"5","author":"Beishuizen","year":"1991","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.hoc.2009.04.009_bib62","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood.V99.7.2315","article-title":"Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease","volume":"99","author":"Szczepanski","year":"2002","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib63","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1365-2141.1999.01775.x","article-title":"Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates","volume":"107","author":"Brady","year":"1999","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib64","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood.V58.2.214.214","article-title":"Terminal deoxynucleotidyl transferase-containing cells in peripheral blood: implications for the surveillance of patients with lymphoblastic leukemia or lymphoma in remission","volume":"58","author":"Froehlich","year":"1981","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib65","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1182\/blood.V99.2.531","article-title":"Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils","volume":"99","author":"Meru","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib66","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1309\/L3UW-3AE7-L4LB-3QX3","article-title":"Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients","volume":"118","author":"Onciu","year":"2002","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib67","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1182\/blood.V98.8.2498","article-title":"Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry","volume":"98","author":"McKenna","year":"2001","journal-title":"Blood"},{"issue":"Suppl","key":"10.1016\/j.hoc.2009.04.009_bib68","first-page":"S19","article-title":"Role of flow cytometry in pediatric hematopathology","volume":"122","author":"Kroft","year":"2004","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib69","first-page":"1","article-title":"Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: reference patterns for age-related changes and disease-induced shifts","volume":"60","author":"van Lochem","year":"2004","journal-title":"Cytometry B\u00a0Clin Cytom"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib70","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/sj.leu.2400732","article-title":"Multiparameter phenotype mapping of normal and post-chemotherapy B lymphopoiesis in pediatric bone marrow","volume":"11","author":"Dworzak","year":"1997","journal-title":"Leukemia"},{"issue":"20","key":"10.1016\/j.hoc.2009.04.009_bib71","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1158\/0008-5472.CAN-04-1865","article-title":"PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia","volume":"64","author":"Tiacci","year":"2004","journal-title":"Cancer Res"},{"issue":"3-4","key":"10.1016\/j.hoc.2009.04.009_bib72","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/10428190009089432","article-title":"Terminal deoxynucleotidyl transferase expression in acute myelogenous leukemia and myelodysplasia as determined by flow cytometry","volume":"37","author":"Huh","year":"2000","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib73","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1080\/10428190500353216","article-title":"Acute leukemia of dendritic cell lineage in childhood: incidence, biological characteristics and outcome","volume":"47","author":"Rossi","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"10.1016\/j.hoc.2009.04.009_bib74","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1182\/blood.V99.5.1556","article-title":"Clinical and biologic features of CD4(+)CD56(+) malignancies","volume":"99","author":"Feuillard","year":"2002","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0145-2126(02)00129-7","article-title":"The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype","volume":"27","author":"Chan","year":"2003","journal-title":"Leuk Res"},{"issue":"6","key":"10.1016\/j.hoc.2009.04.009_bib76","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0145-2126(02)00271-0","article-title":"Burkitt's leukemia with precursor B-cell immunophenotype and atypical morphology (atypical Burkitt's leukemia\/lymphoma): case report and review of literature","volume":"27","author":"Komrokji","year":"2003","journal-title":"Leuk Res"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib77","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.leu.2401244","article-title":"Acute lymphoblastic leukemia with the (8;14) (q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience","volume":"13","author":"Navid","year":"1999","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib78","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1309\/WH8PNU9PK4RRV852","article-title":"ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature","volume":"120","author":"Onciu","year":"2003","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib79","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1309\/HEFL7KC435KFWEX8","article-title":"Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry","volume":"119","author":"Juco","year":"2003","journal-title":"Am J Clin Pathol"},{"issue":"11","key":"10.1016\/j.hoc.2009.04.009_bib80","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/modpathol.3880455","article-title":"Differentiating lymphoblastic lymphoma and Ewing's sarcoma: lymphocyte markers and gene rearrangement","volume":"14","author":"Ozdemirli","year":"2001","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1016\/j.hoc.2009.04.009_bib81","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1309\/R494HQ9VRDJWDY30","article-title":"Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall","volume":"129","author":"Buresh","year":"2008","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"10.1016\/j.hoc.2009.04.009_bib82","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/01.pas.0000155162.33044.4f","article-title":"B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in merkel cell carcinoma and small cell carcinomas","volume":"29","author":"Dong","year":"2005","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.hoc.2009.04.009_bib83","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/00313020802197871","article-title":"Pax-5 protein expression in bladder cancer: a preliminary study that shows no correlation to grade, stage or clinical outcome","volume":"40","author":"Denzinger","year":"2008","journal-title":"Pathology"},{"issue":"6","key":"10.1016\/j.hoc.2009.04.009_bib84","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/jcp.2006.039917","article-title":"Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis","volume":"60","author":"Mhawech-Fauceglia","year":"2007","journal-title":"J Clin Pathol"},{"issue":"5","key":"10.1016\/j.hoc.2009.04.009_bib85","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1309\/XEC7-JMW9-YRM7-4RNO","article-title":"Pax-5 expression in nonhematopoietic tissues","volume":"126","author":"Torlakovic","year":"2006","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib86","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/j.seminhematol.2008.09.003","article-title":"Treatment of adult acute lymphoblastic leukemia","volume":"46","author":"Gokbuget","year":"2009","journal-title":"Semin Hematol"},{"issue":"12","key":"10.1016\/j.hoc.2009.04.009_bib87","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/cncr.20668","article-title":"Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia","volume":"101","author":"Kantarjian","year":"2004","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib88","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1053\/beha.2002.0225","article-title":"Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia","volume":"15","author":"Pui","year":"2002","journal-title":"Best Pract Res Clin Haematol"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib89","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/jama.2009.7","article-title":"Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia","volume":"301","author":"Yang","year":"2009","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.hoc.2009.04.009_bib90","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ng1612","article-title":"Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes","volume":"37","author":"Cheng","year":"2005","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib91","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.leu.2404603","article-title":"Why and how to quantify minimal residual disease in acute lymphoblastic leukemia?","volume":"21","author":"Szczepanski","year":"2007","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.hoc.2009.04.009_bib92","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1182\/blood-2005-07-2708","article-title":"Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia","volume":"107","author":"Bruggemann","year":"2006","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.hoc.2009.04.009_bib93","first-page":"1523","article-title":"Immunophenotypic changes between diagnosis and relapse in childhood acute lymphoblastic leukemia","volume":"9","author":"van Wering","year":"1995","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.hoc.2009.04.009_bib94","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1365-2141.2003.04393.x","article-title":"Determination of minimal residual disease in leukaemia patients","volume":"121","author":"Campana","year":"2003","journal-title":"Br\u00a0J Haematol"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib95","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.seminhematol.2008.09.001","article-title":"Minimal residual disease in acute lymphoblastic leukemia","volume":"46","author":"Campana","year":"2009","journal-title":"Semin Hematol"},{"issue":"1\u20132","key":"10.1016\/j.hoc.2009.04.009_bib96","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000077554","article-title":"Minimal residual disease studies by flow cytometry in acute leukemia","volume":"112","author":"Campana","year":"2004","journal-title":"Acta Haematol"},{"issue":"7","key":"10.1016\/j.hoc.2009.04.009_bib97","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1182\/blood-2002-04-1130","article-title":"Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia","volume":"100","author":"Coustan-Smith","year":"2002","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2009.04.009_bib98","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.leu.2403263","article-title":"Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia","volume":"18","author":"Bruggemann","year":"2004","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.hoc.2009.04.009_bib99","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1038\/sj.leu.2403081","article-title":"Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurrence of second T-ALL","volume":"17","author":"Szczepanski","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.hoc.2009.04.009_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2008.11.031","article-title":"Monitoring minimal residual disease with flow cytometry, antigen-receptor gene rearrangements and fusion transcript quantification in Philadelphia-positive childhood acute lymphoblastic leukemia","author":"Thorn","year":"2009","journal-title":"Leuk Res"},{"key":"10.1016\/j.hoc.2009.04.009_bib101","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia","author":"Mullighan","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.hoc.2009.04.009_bib102","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/sj.leu.2401269","article-title":"Clonal stability in children with acute lymphoblastic leukemia (ALL) who relapsed five or more years after diagnosis","volume":"13","author":"Lo","year":"1999","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.hoc.2009.04.009_bib103","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1309\/7R6MU7R9YWJBY5V4","article-title":"Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia\/lymphoma: a single institution experience","volume":"127","author":"Chen","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"7","key":"10.1016\/j.hoc.2009.04.009_bib104","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/sj.leu.2404718","article-title":"Childhood secondary ALL after ALL treatment","volume":"21","author":"Zuna","year":"2007","journal-title":"Leukemia"},{"issue":"5906","key":"10.1016\/j.hoc.2009.04.009_bib105","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.1164266","article-title":"Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia","volume":"322","author":"Mullighan","year":"2008","journal-title":"Science"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858809000859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858809000859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:52:07Z","timestamp":1760183527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858809000859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0889858809000859"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2009.04.009","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Lymphoblastic Leukemia","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2009.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}