{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:06:40Z","timestamp":1781114800159,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.hoc.2009.09.003","type":"journal-article","created":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T06:51:15Z","timestamp":1258786275000},"page":"1155-1161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Immune Thrombocytopenia Syndrome: A Disorder of Diverse Pathogenesis and Clinical Presentation"],"prefix":"10.1016","volume":"23","author":[{"given":"Douglas B.","family":"Cines","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Liebman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hoc.2009.09.003_bib1","unstructured":"Werlhof PG. Disquisitio medica et philologica de variolis et anthracibus. Hannover, 1735 [in Latin]."},{"key":"10.1016\/j.hoc.2009.09.003_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-0028-1086134","article-title":"Idiopathic thrombocytopenic purpura (ITP): clinical and immunologic considerations","volume":"3","author":"Mueller-Eckhardt","year":"1977","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.hoc.2009.09.003_bib3","first-page":"454","article-title":"Die Essentielle Thrombopenia (Konstitutionelle purpura-Pseudohamophilie). I. Klinische Bild. H. Pathogenese","volume":"52","author":"Frank","year":"1915","journal-title":"Berl Klin Wochenschr"},{"key":"10.1016\/j.hoc.2009.09.003_bib4","first-page":"1451","article-title":"Verschwinden der hamorrhagischen diathese bei einem Falle von \u201cessentieller Thrombopenie\u201d (FRANK) nach Milzexstirpation. Splenogene thrombolytische Purpura","volume":"29","author":"Kaznelson","year":"1916","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.hoc.2009.09.003_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1182\/blood.V1.1.27.27","article-title":"The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism","volume":"1","author":"Dameshek","year":"1946","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archinte.1951.03810010058005","article-title":"Primary thrombocytopenic purpura and acquired hemolytic anemia: evidence for a common etiology","volume":"87","author":"Evans","year":"1951","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.hoc.2009.09.003_bib7","first-page":"1","article-title":"Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura","volume":"38","author":"Harrington","year":"1951","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.hoc.2009.09.003_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1749-6632.1965.tb18984.x","article-title":"Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic thrombocytopenic purpura. Physiologic, serologic and isotopic studies","volume":"124","author":"Shulman","year":"1965","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.hoc.2009.09.003_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-38-3-433","article-title":"Immunologic mechanism in idiopathic and neonatal thrombocytopenic purpura","volume":"38","author":"Harrington","year":"1953","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hoc.2009.09.003_bib10","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1182\/blood.V79.6.1441.1441","article-title":"Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura","volume":"79","author":"Fujisawa","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1182\/blood.V65.3.584.584","article-title":"Platelet kinetics with idiopathic thrombocytopenic purpura and moderate thrombocytopenia","volume":"65","author":"Stoll","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1172\/JCI113060","article-title":"Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance","volume":"80","author":"Ballem","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hoc.2009.09.003_bib13","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1056\/NEJM198904133201505","article-title":"Mechanisms of response to treatment in autoimmune thrombocytopenic purpura","volume":"320","author":"Gernsheimer","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hoc.2009.09.003_bib14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1182\/blood-2003-08-2672","article-title":"Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP","volume":"103","author":"McMillan","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1182\/blood-2002-05-1475","article-title":"Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro","volume":"102","author":"Chang","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI4238","article-title":"Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody","volume":"102","author":"Kuwana","year":"1998","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"10.1016\/j.hoc.2009.09.003_bib17","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/00043426-200312001-00003","article-title":"Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura","volume":"25","author":"Semple","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.hoc.2009.09.003_bib18","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2007-12-129262","article-title":"Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab","volume":"112","author":"Stasi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMra010501","article-title":"Immune thrombocytopenic purpura","volume":"346","author":"Cines","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hoc.2009.09.003_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/MOH.0b013e3282ab9904","article-title":"Secondary immune thrombocytopenic purpura","volume":"14","author":"Liebman","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.hoc.2009.09.003_bib21","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1182\/blood-2008-07-167155","article-title":"Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review","volume":"113","author":"Stasi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib22","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1182\/blood-2009-01-129155","article-title":"The ITP syndrome: a diverse set of disorders with different immune mechanisms","volume":"113","author":"Cines","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2009.09.003_bib23","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and decisional criteria in immune thrombocytopenic purpura (ITP) in adults and children. Report from an International Working Group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858809001774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858809001774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:52:10Z","timestamp":1760183530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858809001774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0889858809001774"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2009.09.003","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Immune Thrombocytopenia Syndrome: A Disorder of Diverse Pathogenesis and Clinical Presentation","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2009.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}