{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:30:23Z","timestamp":1760239823005,"version":"build-2065373602"},"reference-count":80,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.hoc.2011.09.002","type":"journal-article","created":{"date-parts":[[2011,10,22]],"date-time":"2011-10-22T06:07:11Z","timestamp":1319263631000},"page":"967-980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Biology of Chronic Myelogenous Leukemia Progression: Who, What, Where, and Why?"],"prefix":"10.1016","volume":"25","author":[{"given":"Jerald P.","family":"Radich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1182\/blood-2002-09-2896","article-title":"Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis","volume":"102","author":"Branford","year":"2003","journal-title":"Blood"},{"issue":"18","key":"10.1016\/j.hoc.2011.09.002_bib2","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1200\/JCO.2005.05.531","volume":"23","author":"Soverini","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"issue":"6","key":"10.1016\/j.hoc.2011.09.002_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","article-title":"Chronic myeloid leukaemia as a model of disease evolution in human cancer","volume":"7","author":"Melo","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.002_bib4","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.6004\/jnccn.2007.0043","article-title":"Chronic myelogenous leukemia","volume":"5","author":"O\u2019Brien","year":"2007","journal-title":"J\u00a0Natl Compr Canc Netw"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.002_bib6","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.0510423103","article-title":"Gene expression changes associated with progression and response in chronic myeloid leukemia","volume":"103","author":"Radich","year":"2006","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12185-008-0230-0","article-title":"Chronic myeloid leukemia in Asia","volume":"89","author":"Au","year":"2009","journal-title":"Int J Hematol"},{"issue":"9","key":"10.1016\/j.hoc.2011.09.002_bib8","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood.V99.9.3472","article-title":"High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR\/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance","volume":"99","author":"Branford","year":"2002","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.002_bib9","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/sj.leu.2403158","article-title":"Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase","volume":"17","author":"Branford","year":"2003","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1535-6108(02)00096-X","article-title":"Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia","volume":"2","author":"Shah","year":"2002","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood-2005-07-2815","article-title":"BCR\/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance","volume":"108","author":"Koptyra","year":"2006","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib12","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1182\/blood-2004-03-1114","article-title":"Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment","volume":"105","author":"Chu","year":"2005","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.hoc.2011.09.002_bib13","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/jnci\/djk150","article-title":"Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells","volume":"99","author":"Jiang","year":"2007","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood.V69.3.893.893","article-title":"Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis","volume":"69","author":"Collins","year":"1987","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.002_bib15","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1182\/blood.V99.12.4547","article-title":"Derivative chromosome 9 deletions in\u00a0chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability","volume":"99","author":"Huntly","year":"2002","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.hoc.2011.09.002_bib16","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1182\/blood-2002-09-2763","article-title":"Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions","volume":"102","author":"Huntly","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1084\/jem.181.1.307","article-title":"Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene","volume":"181","author":"Sawyers","year":"1995","journal-title":"J\u00a0Exp Med"},{"issue":"49","key":"10.1016\/j.hoc.2011.09.002_bib18","doi-asserted-by":"crossref","first-page":"31704","DOI":"10.1074\/jbc.271.49.31704","article-title":"P210 and P190(BCR\/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members","volume":"271","author":"Ilaria","year":"1996","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib19","first-page":"247","article-title":"Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia","volume":"13","author":"Shuai","year":"1996","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1182\/blood.V86.2.726.bloodjournal862726","article-title":"Phosphatidylinositol-3 kinase activity is regulated by BCR\/ABL and is required for the growth of Philadelphia chromosome-positive cells","volume":"86","author":"Skorski","year":"1995","journal-title":"Blood"},{"issue":"49","key":"10.1016\/j.hoc.2011.09.002_bib21","doi-asserted-by":"crossref","first-page":"29145","DOI":"10.1074\/jbc.270.49.29145","article-title":"CRKL links p210BCR\/ABL with paxillin in chronic myelogenous leukemia cells","volume":"270","author":"Salgia","year":"1995","journal-title":"J\u00a0Biol Chem"},{"issue":"19","key":"10.1016\/j.hoc.2011.09.002_bib22","doi-asserted-by":"crossref","first-page":"8912","DOI":"10.1158\/0008-5472.CAN-05-0076","article-title":"Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia","volume":"65","author":"Barnes","year":"2005","journal-title":"Cancer Res"},{"issue":"42","key":"10.1016\/j.hoc.2011.09.002_bib23","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1038\/sj.onc.1208796","article-title":"Dose-dependent effects of Bcr-Abl in cell line models of different stages of chronic myeloid leukemia","volume":"24","author":"Barnes","year":"2005","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.002_bib24","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1182\/blood-2006-06-032490","article-title":"Role of BCR\/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells","volume":"109","author":"Modi","year":"2007","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.hoc.2011.09.002_bib25","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1158\/1078-0432.CCR-06-2320","article-title":"From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way","volume":"13","author":"Perrotti","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1016\/j.hoc.2011.09.002_bib26","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1073\/pnas.0900189106","article-title":"Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation","volume":"106","author":"Abrahamsson","year":"2009","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.002_bib27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.onc.1209133","article-title":"BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells","volume":"25","author":"Klein","year":"2006","journal-title":"Oncogene"},{"issue":"5858","key":"10.1016\/j.hoc.2011.09.002_bib28","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.002_bib29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ng.392","article-title":"Lin28 promotes transformation and is associated with advanced human malignancies","volume":"41","author":"Viswanathan","year":"2009","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.hoc.2011.09.002_bib30","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1182\/blood-2003-12-4111","article-title":"The biology of CML blast crisis","volume":"103","author":"Calabretta","year":"2004","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.002_bib31","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/sj.leu.2402577","article-title":"Chronic myelogenous leukemia: mechanisms underlying disease progression","volume":"16","author":"Shet","year":"2002","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrc799","article-title":"Oncogenic tyrosine kinases and the DNA-damage response","volume":"2","author":"Skorski","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.hoc.2011.09.002_bib33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/cbir.2002.0865","article-title":"Does the BCR\/ABL-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells?","volume":"26","author":"Majsterek","year":"2002","journal-title":"Cell Biol Int"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.002_bib34","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1128\/MCB.22.12.4189-4201.2002","article-title":"Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)\/M phase, and protection from apoptosis","volume":"22","author":"Slupianek","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"32","key":"10.1016\/j.hoc.2011.09.002_bib35","doi-asserted-by":"crossref","first-page":"24273","DOI":"10.1074\/jbc.M002094200","article-title":"The BCR\/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells","volume":"275","author":"Sattler","year":"2000","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V94.1.225.413k24_225_232","article-title":"Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations","volume":"94","author":"Fioretos","year":"1999","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.hoc.2011.09.002_bib38","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0092-8674(92)90241-4","article-title":"Dominant negative MYC blocks transformation by ABL oncogenes","volume":"70","author":"Sawyers","year":"1992","journal-title":"Cell"},{"issue":"5875","key":"10.1016\/j.hoc.2011.09.002_bib39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/298679a0","article-title":"Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line","volume":"298","author":"Collins","year":"1982","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib40","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1073\/pnas.98.3.1124","article-title":"Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics","volume":"98","author":"Virtaneva","year":"2001","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"9","key":"10.1016\/j.hoc.2011.09.002_bib41","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/cncr.11729","article-title":"Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase","volume":"98","author":"Medina","year":"2003","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib42","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/j.1460-2075.1994.tb06288.x","article-title":"Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia","volume":"13","author":"Mitani","year":"1994","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib43","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng0296-154","article-title":"Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia","volume":"12","author":"Nakamura","year":"1996","journal-title":"Nat Genet"},{"issue":"57","key":"10.1016\/j.hoc.2011.09.002_bib44","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1038\/sj.onc.1205095","article-title":"Cooperation of BCR-ABL and AML1\/MDS1\/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia","volume":"20","author":"Cuenco","year":"2001","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.hoc.2011.09.002_bib45","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1073\/pnas.102583199","article-title":"A\u00a0murine model of CML blast crisis induced by cooperation between BCR\/ABL and NUP98\/HOXA9","volume":"99","author":"Dash","year":"2002","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"7307","key":"10.1016\/j.hoc.2011.09.002_bib46","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nature09171","article-title":"Regulation of myeloid leukaemia by the cell-fate determinant Musashi","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.hoc.2011.09.002_bib47","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1182\/blood.V73.4.1028.1028","article-title":"Rare occurrence of N-ras point mutations in Philadelphia chromosome positive chronic myeloid leukemia","volume":"73","author":"Collins","year":"1989","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.hoc.2011.09.002_bib48","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1073\/pnas.86.17.6783","article-title":"Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia","volume":"86","author":"Ahuja","year":"1989","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.002_bib49","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood.V85.8.2013.bloodjournal8582013","article-title":"Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia","volume":"85","author":"Sill","year":"1995","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccr.2005.10.015","article-title":"The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR\/ABL-regulated SET protein","volume":"8","author":"Neviani","year":"2005","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib51","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1182\/blood-2007-03-078303","article-title":"High levels of the BCR\/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C\/EBPalpha-driven myeloid differentiation","volume":"110","author":"Chang","year":"2007","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ng791","article-title":"BCR-ABL suppresses C\/EBPalpha expression through inhibitory action of hnRNP E2","volume":"30","author":"Perrotti","year":"2002","journal-title":"Nat Genet"},{"issue":"16","key":"10.1016\/j.hoc.2011.09.002_bib53","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1073\/pnas.0508143103","article-title":"Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr\/abl-induced malignancy","volume":"103","author":"Wagner","year":"2006","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"5307","key":"10.1016\/j.hoc.2011.09.002_bib54","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.002_bib55","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/sj.bjc.6601265","article-title":"Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta","volume":"89","author":"Rask","year":"2003","journal-title":"Br J Cancer"},{"issue":"46","key":"10.1016\/j.hoc.2011.09.002_bib56","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1038\/sj.onc.1206817","article-title":"Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression","volume":"22","author":"Uematsu","year":"2003","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.002_bib57","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1182\/blood-2006-11-059071","article-title":"{beta}-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation","volume":"109","author":"Guo","year":"2007","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.002_bib58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib59","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.10.010","article-title":"JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells","volume":"119","author":"Passegue","year":"2004","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.hoc.2011.09.002_bib60","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.leukres.2009.03.044","article-title":"Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia","volume":"33","author":"Hoshino","year":"2009","journal-title":"Leuk Res"},{"issue":"22","key":"10.1016\/j.hoc.2011.09.002_bib61","doi-asserted-by":"crossref","first-page":"14183","DOI":"10.1016\/S0021-9258(18)98664-3","article-title":"A\u00a0retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells","volume":"266","author":"Hromas","year":"1991","journal-title":"J\u00a0Biol Chem"},{"issue":"13","key":"10.1016\/j.hoc.2011.09.002_bib62","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1101\/gad.902301","article-title":"Mzf1 controls cell proliferation and tumorigenesis","volume":"15","author":"Gaboli","year":"2001","journal-title":"Genes Dev"},{"issue":"11","key":"10.1016\/j.hoc.2011.09.002_bib63","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1128\/MCB.15.11.6075","article-title":"Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity","volume":"15","author":"Perrotti","year":"1995","journal-title":"Mol Cell Biol"},{"issue":"42","key":"10.1016\/j.hoc.2011.09.002_bib64","doi-asserted-by":"crossref","first-page":"39209","DOI":"10.1074\/jbc.M206400200","article-title":"Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression","volume":"277","author":"Guaita","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.002_bib65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yexcr.2004.08.028","article-title":"Sp1\/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts","volume":"302","author":"Le Mee","year":"2005","journal-title":"Exp Cell Res"},{"issue":"6","key":"10.1016\/j.hoc.2011.09.002_bib66","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.bjc.6601685","article-title":"Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells","volume":"90","author":"Miyoshi","year":"2004","journal-title":"Br J Cancer"},{"issue":"18","key":"10.1016\/j.hoc.2011.09.002_bib67","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1128\/MCB.22.18.6393-6405.2002","article-title":"I-Mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways","volume":"22","author":"Kusano","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"5663","key":"10.1016\/j.hoc.2011.09.002_bib68","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"issue":"7191","key":"10.1016\/j.hoc.2011.09.002_bib69","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature06866","article-title":"BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros","volume":"453","author":"Mullighan","year":"2008","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.hoc.2011.09.002_bib70","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1002\/cncr.24531","article-title":"Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis","volume":"115","author":"Gratwohl","year":"2009","journal-title":"Cancer"},{"issue":"7239","key":"10.1016\/j.hoc.2011.09.002_bib71","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature07737","article-title":"Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia","volume":"458","author":"Zhao","year":"2009","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib72","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10555-008-9119-x","article-title":"Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias","volume":"27","author":"Perrotti","year":"2008","journal-title":"Cancer Metastasis Rev"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib73","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1182\/blood-2007-09-112573","article-title":"BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors","volume":"111","author":"Copland","year":"2008","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2011.09.002_bib74","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/03093640701859089","article-title":"BCR\/ABL, DNA damage and DNA repair: implications for new treatment concepts","volume":"49","author":"Skorski","year":"2008","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.002_bib75","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1182\/blood-2002-07-2053","article-title":"Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority","volume":"101","author":"Bumm","year":"2003","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.002_bib76","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.leu.2402848","article-title":"Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate","volume":"17","author":"O\u2019Dwyer","year":"2003","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.002_bib77","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood.V86.8.3118.3118","article-title":"Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals","volume":"86","author":"Biernaux","year":"1995","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.hoc.2011.09.002_bib78","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1182\/blood.V92.9.3362","article-title":"The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease","volume":"92","author":"Bose","year":"1998","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.hoc.2011.09.002_bib79","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1182\/blood-2009-03-212969","article-title":"The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data","volume":"114","author":"Oehler","year":"2009","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.002_bib80","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/leu.2008.183","article-title":"Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR","volume":"23","author":"Oehler","year":"2009","journal-title":"Leukemia"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858811000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858811000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:55:14Z","timestamp":1760183714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858811000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0889858811000992"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2011.09.002","relation":{},"ISSN":["0889-8588"],"issn-type":[{"type":"print","value":"0889-8588"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Biology of Chronic Myelogenous Leukemia Progression: Who, What, Where, and Why?","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2011.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}