{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:34:21Z","timestamp":1791232461993,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.hoc.2011.09.012","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T07:50:22Z","timestamp":1320306622000},"page":"1067-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Systemic Mastocytosis"],"prefix":"10.1016","volume":"25","author":[{"given":"Tracy I.","family":"George","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Horny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.hoc.2011.09.012_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1309\/AJCPPXHMN5CJOXHZ","article-title":"Mastocytosis: an unusual clonal disorder of bone marrow-derived hematopoietic progenitor cells","volume":"132","author":"Horny","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.hoc.2011.09.012_bib2","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon (France)","first-page":"53","article-title":"Mastocytosis","author":"Horny","year":"2008"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.012_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2004.02.045","article-title":"Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms","volume":"114","author":"Valent","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.012_bib4","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0046-8177(85)80252-5","article-title":"Bone marrow findings in systemic mastocytosis","volume":"16","author":"Horny","year":"1985","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.012_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000101711","article-title":"Mastocytosis: state of the art","volume":"74","author":"Horny","year":"2007","journal-title":"Pathobiology"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.012_bib6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.thj.6200164","article-title":"Myelomastocytic leukemia: myeloid neoplasm characterized by partial differentiation of mast cell-lineage cells","volume":"3","author":"Valent","year":"2002","journal-title":"Hematol J"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.012_bib7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"issue":"4","key":"10.1016\/j.hoc.2011.09.012_bib8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1309\/CX45R79PCU9HCV6V","article-title":"Delineation of patterns of bone marrow mast cell infiltration in systemic\u00a0mastocytosis: value of CD25, correlation with subvariations of the disease and separation from mast cell\u00a0hyperplasia","volume":"124","author":"Krokowski","year":"2005","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.012_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/jcp.2005.028738","article-title":"The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers","volume":"59","author":"Horny","year":"2006","journal-title":"J\u00a0Clin Pathol"},{"issue":"5\u20136","key":"10.1016\/j.hoc.2011.09.012_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/10428190009058500","article-title":"Clinical and biological diversity of leukemias occurring in patients with mastocytosis","volume":"37","author":"Sperr","year":"2000","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"10.1016\/j.hoc.2011.09.012_bib11","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/01.pas.0000138181.89743.7b","article-title":"CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis in routinely processed bone marrow biopsy specimens","volume":"28","author":"Sotlar","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.012_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.10072","article-title":"Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposals of the Spanish network on mastocytosis (REMA)","volume":"58","author":"Escribano","year":"2004","journal-title":"Cytometry B Clin Cytom"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.012_bib13","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1182\/blood-2006-04-015545","article-title":"KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish network on mastocytosis (REMA) in a series of 113 patients","volume":"108","author":"Garcia-Montero","year":"2006","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.hoc.2011.09.012_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000048179","article-title":"Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts","volume":"127","author":"Feger","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.012_bib15","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/jid.2009.281","article-title":"Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations","volume":"130","author":"Bodemer","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.012_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2559.2008.02977.x","article-title":"Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours","volume":"53","author":"Lasota","year":"2008","journal-title":"Histopathology"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.012_bib17","first-page":"920","article-title":"KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication","volume":"89","author":"Beghini","year":"2004","journal-title":"Haematologica"},{"issue":"13","key":"10.1016\/j.hoc.2011.09.012_bib18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A\u00a0tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N\u00a0Engl J\u00a0Med"},{"issue":"3","key":"10.1016\/j.hoc.2011.09.012_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.iac.2007.06.001","article-title":"Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome","volume":"27","author":"Bain","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"issue":"7","key":"10.1016\/j.hoc.2011.09.012_bib20","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1182\/blood.V98.7.2200","article-title":"Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia","volume":"98","author":"Sperr","year":"2001","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.012_bib21","first-page":"600","article-title":"Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge","volume":"85","author":"Arredondo","year":"2010","journal-title":"Am J\u00a0Hematol"},{"issue":"9","key":"10.1016\/j.hoc.2011.09.012_bib22","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1182\/blood-2003-05-1627","article-title":"CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy","volume":"102","author":"Pardanani","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.hoc.2011.09.012_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1182\/blood.V40.4.464.464","article-title":"Eosinophilic fibrohistiocytic lesion of bone marrow: a distinctive new morphologic finding, probably related to drug hypersensitivity","volume":"40","author":"Rywlin","year":"1972","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.012_bib24","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1182\/blood-2003-11-3816","article-title":"A\u00a0novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib","volume":"103","author":"Akin","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.hoc.2011.09.012_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0091-6749(05)80132-0","article-title":"Lymphadenopathic mastocytosis with eosinophilia and biclonal gammopathy","volume":"86","author":"Frieri","year":"1990","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.hoc.2011.09.012_bib26","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1080\/10428190412331272695","article-title":"A\u00a0leukemic mast cell leukemia with abnormal immunophenotype and c-kit mutation D816V","volume":"45","author":"Noack","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"16","key":"10.1016\/j.hoc.2011.09.012_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00277-007-0430-3","article-title":"Mast cell leukemia: a report of ten cases","volume":"87","author":"Valentini","year":"2008","journal-title":"Ann Hematol"},{"issue":"19 Pt 1","key":"10.1016\/j.hoc.2011.09.012_bib28","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.1158\/1078-0432.CCR-05-1064","article-title":"Myelomastocytic leukemia: evidence for the origin of mast cells from the leukemic clone and eradication by allogeneic stem cell transplantation","volume":"11","author":"Sperr","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.012_bib29","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1182\/blood.V99.5.1741","article-title":"The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations","volume":"99","author":"Ma","year":"2002","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.hoc.2011.09.012_bib30","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1182\/blood-2005-04-1568","article-title":"Activity of tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation","volume":"106","author":"Gotlib","year":"2005","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.hoc.2011.09.012_bib31","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1158\/1078-0432.CCR-08-0366","article-title":"Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis","volume":"14","author":"Verstovsek","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.hoc.2011.09.012_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.leukres.2008.09.027","article-title":"Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V","volume":"33","author":"Ustun","year":"2009","journal-title":"Leuk Res"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858811001092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858811001092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:56:13Z","timestamp":1760183773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858811001092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0889858811001092"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2011.09.012","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Mastocytosis","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2011.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}