{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:53:01Z","timestamp":1774410781481,"version":"3.50.1"},"reference-count":107,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.hoc.2015.08.003","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:26:54Z","timestamp":1445560014000},"page":"1045-1060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anticipation of the Impact of Human Papillomavirus on Clinical Decision Making for the Head and Neck Cancer Patient"],"prefix":"10.1016","volume":"29","author":[{"given":"Maura L.","family":"Gillison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Restighini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.hoc.2015.08.003_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.hoc.2015.08.003_bib3","first-page":"670","volume":"vol. 90","year":"2007"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/rmv.605","article-title":"Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins","volume":"19","author":"Yugawa","year":"2009","journal-title":"Rev Med Virol"},{"issue":"8","key":"10.1016\/j.hoc.2015.08.003_bib5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2886","article-title":"Human papillomavirus oncoproteins: pathways to transformation","volume":"10","author":"Moody","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"4951","key":"10.1016\/j.hoc.2015.08.003_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.2157286","article-title":"Association of human papillomavirus types 16 and 18 E6 proteins with p53","volume":"248","author":"Werness","year":"1990","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.hoc.2015.08.003_bib7","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1128\/JVI.75.9.4467-4472.2001","article-title":"Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein","volume":"75","author":"Veldman","year":"2001","journal-title":"J\u00a0Virol"},{"issue":"23","key":"10.1016\/j.hoc.2015.08.003_bib8","first-page":"7075","article-title":"The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability","volume":"62","author":"Duensing","year":"2002","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ng.3178","article-title":"Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism","volume":"47","author":"Hu","year":"2015","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib10","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1158\/0008-5472.CAN-04-0009","article-title":"Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract","volume":"64","author":"Wentzensen","year":"2004","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib11","doi-asserted-by":"crossref","first-page":"e88718","DOI":"10.1371\/journal.pone.0088718","article-title":"Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression","volume":"9","author":"Olthof","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.hoc.2015.08.003_bib12","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/hed.23034","article-title":"Viral load, physical status, and E6\/E7 mRNA expression of human papillomavirus in head and neck squamous cell carcinoma","volume":"35","author":"Deng","year":"2013","journal-title":"Head Neck"},{"issue":"3","key":"10.1016\/j.hoc.2015.08.003_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jcv.2013.12.006","article-title":"Mate pair sequencing of oropharyngeal squamous cell carcinomas reveals that HPV integration occurs much less frequently than in cervical cancer","volume":"59","author":"Gao","year":"2014","journal-title":"J\u00a0Clin Virol"},{"issue":"4","key":"10.1016\/j.hoc.2015.08.003_bib14","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1158\/0008-5472.CAN-03-3214","article-title":"Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes","volume":"64","author":"Pett","year":"2004","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/path.2206","article-title":"An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events","volume":"213","author":"Winder","year":"2007","journal-title":"J\u00a0Pathol"},{"issue":"20","key":"10.1016\/j.hoc.2015.08.003_bib16","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1158\/0008-5472.CAN-08-1741","article-title":"Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions","volume":"68","author":"Dall","year":"2008","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib17","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1073\/pnas.92.5.1654","article-title":"Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis","volume":"92","author":"Jeon","year":"1995","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"10","key":"10.1016\/j.hoc.2015.08.003_bib18","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1073\/pnas.0600078103","article-title":"Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response","volume":"103","author":"Pett","year":"2006","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib19","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1002\/j.1460-2075.1987.tb02662.x","article-title":"The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region","volume":"6","author":"Thierry","year":"1987","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1101\/gr.164806.113","article-title":"Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability","volume":"24","author":"Akagi","year":"2014","journal-title":"Genome Res"},{"issue":"7488","key":"10.1016\/j.hoc.2015.08.003_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12881","article-title":"Landscape of genomic alterations in cervical carcinomas","volume":"506","author":"Ojesina","year":"2014","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.hoc.2015.08.003_bib22","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1073\/pnas.1416074111","article-title":"Characterization of HPV and host genome interactions in primary head and neck cancers","volume":"111","author":"Parfenov","year":"2014","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"Suppl 5","key":"10.1016\/j.hoc.2015.08.003_bib23","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1016\/j.vaccine.2012.05.070","article-title":"Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis","volume":"30","author":"Gillison","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.hoc.2015.08.003_bib24","unstructured":"Gillison M, Chaturvedi A, Anderson W, et\u00a0al. The epidemiology of HPV-positive head and neck squamous cell carcinoma. J Clin Oncol, in press."},{"issue":"15","key":"10.1016\/j.hoc.2015.08.003_bib25","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1056\/NEJM200104123441503","article-title":"Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck","volume":"344","author":"Mork","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"21","key":"10.1016\/j.hoc.2015.08.003_bib26","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1200\/JCO.2012.47.2738","article-title":"Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer","volume":"31","author":"Kreimer","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"9","key":"10.1016\/j.hoc.2015.08.003_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","article-title":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers","volume":"92","author":"Gillison","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.hoc.2015.08.003_bib28","unstructured":"Castellsague X, Alemany L, Holzinger D, et\u00a0al. Estimation of the HPV etiological fraction in over 4,000 head and neck cancers worldwide. International Human Papillomavirus Conference. Seattle (WA), 2014. p. 224."},{"issue":"19","key":"10.1016\/j.hoc.2015.08.003_bib29","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1056\/NEJMoa065497","article-title":"Case-control study of human papillomavirus and oropharyngeal cancer","volume":"356","author":"D'Souza","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jama.2012.101","article-title":"Prevalence of oral HPV infection in the United States, 2009-2010","volume":"307","author":"Gillison","year":"2012","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/aje\/kwu247","article-title":"Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults","volume":"181","author":"Beachler","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib32","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/OLQ.0b013e318269d098","article-title":"Rates and determinants of oral human papillomavirus infection in young men","volume":"39","author":"Edelstein","year":"2012","journal-title":"Sex Transm Dis"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/OLQ.0b013e31824f1c65","article-title":"The prevalence and incidence of oral human papillomavirus infection among young men and women, age 18-30 years","volume":"39","author":"Pickard","year":"2012","journal-title":"Sex Transm Dis"},{"issue":"9895","key":"10.1016\/j.hoc.2015.08.003_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0140-6736(13)60809-0","article-title":"Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study","volume":"382","author":"Kreimer","year":"2013","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib35","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1158\/0008-5472.CAN-14-2843","article-title":"NHANES 2009-2012 Findings: Sexual behaviors and higher prevalence of oral oncogenic human papillomavirus infection among men in the U.S. population","volume":"75","author":"Chaturvedi","year":"2015","journal-title":"Cancer Res"},{"issue":"32","key":"10.1016\/j.hoc.2015.08.003_bib36","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Chaturvedi","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"36","key":"10.1016\/j.hoc.2015.08.003_bib37","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1200\/JCO.2013.50.3870","article-title":"Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers","volume":"31","author":"Chaturvedi","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib38","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1002\/ijc.29082","article-title":"EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection","volume":"136","author":"Giuliano","year":"2015","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"15S","key":"10.1016\/j.hoc.2015.08.003_bib40","first-page":"302","article-title":"Prognostic significance of HPV and p16 status in patients with oropharyngeal cancer treated on a large international phase III trial","volume":"27","author":"Rischin","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"issue":"27","key":"10.1016\/j.hoc.2015.08.003_bib41","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1200\/JCO.2013.53.5633","article-title":"Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522","volume":"32","author":"Ang","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"17","key":"10.1016\/j.hoc.2015.08.003_bib42","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1200\/JCO.2011.38.4099","article-title":"Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer","volume":"30","author":"Gillison","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib43","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/annonc\/mdr006","article-title":"Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial","volume":"22","author":"Posner","year":"2011","journal-title":"Ann Oncol"},{"issue":"15","key":"10.1016\/j.hoc.2015.08.003_bib44","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.ejca.2014.07.001","article-title":"De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials","volume":"50","author":"Masterson","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.hoc.2015.08.003_bib45","doi-asserted-by":"crossref","DOI":"10.1245\/s10434-015-4525-0","article-title":"Detailed analysis of clinicopathologic factors demonstrate distinct difference in outcome and prognostic factors between surgically treated hpv-positive and negative oropharyngeal cancer","author":"Iyer","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.hoc.2015.08.003_bib46","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3109\/00016489.2014.886336","article-title":"The impact of HPV infection on survival in a geographically defined cohort of oropharynx squamous cell carcinoma (OPSCC) patients in whom surgical treatment has been one main treatment","volume":"134","author":"Ljokjel","year":"2014","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.hoc.2015.08.003_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.oraloncology.2014.01.001","article-title":"Adjuvant chemoradiation therapy with high-dose versus weekly cisplatin for resected, locally-advanced HPV\/p16-positive and negative head and neck squamous cell carcinoma","volume":"50","author":"Geiger","year":"2014","journal-title":"Oral Oncol"},{"issue":"10","key":"10.1016\/j.hoc.2015.08.003_bib48","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1158\/0008-5472.CAN-06-3619","article-title":"Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head\/neck and cervical cancers","volume":"67","author":"Pyeon","year":"2007","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.hoc.2015.08.003_bib49","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/path.2227","article-title":"Gene expression profiles in HPV-infected head and neck cancer","volume":"213","author":"Schlect","year":"2007","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.hoc.2015.08.003_bib50","doi-asserted-by":"crossref","first-page":"696028","DOI":"10.1155\/2014\/696028","article-title":"Biological basis for increased sensitivity to radiation therapy in HPV-positive head and neck cancers","volume":"2014","author":"Bol","year":"2014","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib51","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.radonc.2013.03.013","article-title":"HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity","volume":"107","author":"Rieckmann","year":"2013","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.hoc.2015.08.003_bib52","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00066-014-0605-5","article-title":"Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis","volume":"190","author":"Arenz","year":"2014","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"10.1016\/j.hoc.2015.08.003_bib53","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.radonc.2013.06.011","article-title":"Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells","volume":"108","author":"Sorensen","year":"2013","journal-title":"Radiother Oncol"},{"issue":"15","key":"10.1016\/j.hoc.2015.08.003_bib54","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1158\/0008-5472.CAN-13-0587","article-title":"Enhanced radiation sensitivity in HPV-positive head and neck cancer","volume":"73","author":"Kimple","year":"2013","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib55","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/archoto.2009.159","article-title":"Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer","volume":"135","author":"Spanos","year":"2009","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib56","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/hed.21040","article-title":"Preclinical models of HPV+ and HPV- HNSCC in mice: an immune clearance of HPV+ HNSCC","volume":"31","author":"Williams","year":"2009","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib57","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ijc.28015","article-title":"Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer","volume":"133","author":"Vermeer","year":"2013","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1517\/14728222.2013.733699","article-title":"Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47","volume":"17","author":"Soto-Pantoja","year":"2013","journal-title":"Expert Opin Ther Targets"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib59","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/bjc.2013.639","article-title":"Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer","volume":"110","author":"Ward","year":"2014","journal-title":"Br J Cancer"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib60","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1016\/j.ejca.2013.03.019","article-title":"CD8+ and CD4+ tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma","volume":"49","author":"Nordfors","year":"2013","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/lary.22133","article-title":"Infiltrating lymphocytes and human papillomavirus-16\u2013associated oropharyngeal cancer","volume":"122","author":"Wansom","year":"2012","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib62","first-page":"753","article-title":"Oropharyngeal cancer incidence trends: diminishing racial disparities","volume":"22","author":"Brown","year":"2011","journal-title":"Cancer Causes Control"},{"issue":"3","key":"10.1016\/j.hoc.2015.08.003_bib63","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jnci\/djs491","article-title":"Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels","volume":"105","author":"Jemal","year":"2013","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1158\/1940-6207.CAPR-14-0089-T","article-title":"Emergence of HPV16-positive oropharyngeal cancer in Black patients over time: University of Maryland 1992-2007","volume":"8","author":"Zandberg","year":"2015","journal-title":"Cancer Prev Res (Phila)"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib65","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/archoto.2010.246","article-title":"Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans","volume":"137","author":"Chernock","year":"2011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"8","key":"10.1016\/j.hoc.2015.08.003_bib66","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/lary.20984","article-title":"Human papillomavirus-active head and neck cancer and ethnic health disparities","volume":"120","author":"Weinberger","year":"2010","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.amjoto.2013.09.004","article-title":"Racial disparities in human papillomavirus (HPV) associated head and neck cancer","volume":"35","author":"Jiron","year":"2014","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.hoc.2015.08.003_bib68","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.humpath.2013.09.006","article-title":"African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated carcinogenesis","volume":"45","author":"Isayeva","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.hoc.2015.08.003_bib69","article-title":"Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans","author":"Zevallos","year":"2014","journal-title":"Head Neck"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib70","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3201\/eid2005.131311","article-title":"Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States","volume":"20","author":"Steinau","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/hed.21398","article-title":"Case-matching analysis of head and neck squamous cell carcinoma in racial and ethnic minorities in the United States: possible role for human papillomavirus in survival disparities","volume":"33","author":"Schrank","year":"2011","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1022255800411","article-title":"Racial\/ethnic patterns of care for cancers of the oral cavity, pharynx, larynx, sinuses, and salivary glands","volume":"22","author":"Shavers","year":"2003","journal-title":"Cancer Metastasis Rev"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib73","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.oraloncology.2014.09.004","article-title":"Impact of African-American race on presentation, treatment, and survival of head and neck cancer","volume":"50","author":"Mahal","year":"2014","journal-title":"Oral Oncol"},{"issue":"10","key":"10.1016\/j.hoc.2015.08.003_bib74","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/cncr.23889","article-title":"African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients","volume":"113","author":"Molina","year":"2008","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib75","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.oraloncology.2013.09.012","article-title":"Race and competing mortality in advanced head and neck cancer","volume":"50","author":"Zakeri","year":"2014","journal-title":"Oral Oncol"},{"issue":"8","key":"10.1016\/j.hoc.2015.08.003_bib76","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/hed.21584","article-title":"Determinants of head and neck cancer survival by race","volume":"33","author":"Ragin","year":"2011","journal-title":"Head Neck"},{"key":"10.1016\/j.hoc.2015.08.003_bib77","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1158\/1940-6207.CAPR-09-0149","article-title":"Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients","volume":"2","author":"Settle","year":"2009","journal-title":"Cancer Prev Res"},{"issue":"9","key":"10.1016\/j.hoc.2015.08.003_bib78","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1158\/1078-0432.CCR-12-3003","article-title":"Improved survival with HPV among African Americans with oropharyngeal cancer","volume":"19","author":"Worsham","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.hoc.2015.08.003_bib79","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jnci\/85.6.465","article-title":"Racial differences in risk of oral and pharyngeal cancer: alcohol, tobacco, and other determinants","volume":"85","author":"Day","year":"1993","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib80","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/cncr.27989","article-title":"Incidence of potentially human papillomavirus-related neoplasms in the United States, 1978 to 2007","volume":"119","author":"Kurdgelashvili","year":"2013","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib81","doi-asserted-by":"crossref","first-page":"e86023","DOI":"10.1371\/journal.pone.0086023","article-title":"Differences in oral sexual behaviors by gender, age, and race explain observed differences in prevalence of oral human papillomavirus infection","volume":"9","author":"D'Souza","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cncr.27727","article-title":"An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair","volume":"119","author":"Dahlstrom","year":"2013","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.hoc.2015.08.003_bib83","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1200\/JCO.2014.58.6412","article-title":"Refining American Joint Committee on Cancer\/Union for International Cancer Control TNM Stage and Prognostic Groups for Human Papillomavirus-Related Oropharyngeal Carcinomas","volume":"33","author":"Huang","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib84","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F","article-title":"Precisely defining high-risk operable head and neck tumors based on RTOG #85-03 and #88-24: targets for postoperative radiochemotherapy?","volume":"20","author":"Cooper","year":"1998","journal-title":"Head Neck"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib85","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/cncr.21340","article-title":"Risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy","volume":"104","author":"Langendijk","year":"2005","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib86","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/1097-0142(20011215)92:12<3030::AID-CNCR10148>3.0.CO;2-P","article-title":"Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue","volume":"92","author":"Myers","year":"2001","journal-title":"Cancer"},{"issue":"19","key":"10.1016\/j.hoc.2015.08.003_bib87","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"10.1016\/j.hoc.2015.08.003_bib88","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib89","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ijrobp.2012.05.008","article-title":"Long-term follow-up of the RTOG 9501\/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck","volume":"84","author":"Cooper","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.hoc.2015.08.003_bib90","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head Neck"},{"issue":"18","key":"10.1016\/j.hoc.2015.08.003_bib91","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1002\/cncr.28169","article-title":"Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status","volume":"119","author":"Maxwell","year":"2013","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib92","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.oraloncology.2015.02.098","article-title":"High metastatic node number, not extracapsular spread or N-classification is a node-related prognosticator in transorally-resected, neck-dissected p16-positive oropharynx cancer","volume":"51","author":"Sinha","year":"2015","journal-title":"Oral Oncol"},{"issue":"14","key":"10.1016\/j.hoc.2015.08.003_bib93","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1002\/cncr.26671","article-title":"Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma","volume":"118","author":"Sinha","year":"2012","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.hoc.2015.08.003_bib94","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"4","key":"10.1016\/j.hoc.2015.08.003_bib95","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib96","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ijrobp.2013.08.049","article-title":"Temporal nodal regression and regional control after primary radiation therapy for N2-N3 head-and-neck cancer stratified by HPV status","volume":"87","author":"Huang","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib97","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/hed.23690","article-title":"Longer survival in patients with human papillomavirus-related head and neck cancer after positive postradiation planned neck dissection","volume":"37","author":"Huang","year":"2015","journal-title":"Head Neck"},{"issue":"30","key":"10.1016\/j.hoc.2015.08.003_bib98","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1200\/JCO.2014.55.1937","article-title":"Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma","volume":"32","author":"Fakhry","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2015.08.003_bib99","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/jamaoto.2015.136","article-title":"Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy","volume":"141","author":"Trosman","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.oraloncology.2012.07.015","article-title":"Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer","volume":"49","author":"Huang","year":"2013","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.hoc.2015.08.003_bib101","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijrobp.2010.08.031","article-title":"Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy","volume":"82","author":"Huang","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"10.1016\/j.hoc.2015.08.003_bib102","first-page":"4655","article-title":"Recent trends in epidemiology of brain metastases: an overview","volume":"32","author":"Tabouret","year":"2012","journal-title":"Anticancer Res"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib103","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/annonc\/mdu167","article-title":"Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: an analysis of Eastern Cooperative Oncology Group trials","volume":"25","author":"Argiris","year":"2014","journal-title":"Ann Oncol"},{"issue":"12","key":"10.1016\/j.hoc.2015.08.003_bib104","first-page":"812","article-title":"The role of HPV status in recurrent\/metastatic squamous cell carcinoma of the head and neck","volume":"12","author":"Misiukiewicz","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"issue":"4","key":"10.1016\/j.hoc.2015.08.003_bib105","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/annonc\/mdu095","article-title":"Demystifying the role of tumor HPV status in recurrent and\/or metastatic squamous cell carcinoma of the head and neck","volume":"25","author":"Spreafico","year":"2014","journal-title":"Ann Oncol"},{"issue":"7","key":"10.1016\/j.hoc.2015.08.003_bib106","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/ijc.28847","article-title":"Treatment de-escalation in HPV-positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives","volume":"136","author":"Mirghani","year":"2015","journal-title":"Int J Cancer"},{"issue":"5 Suppl","key":"10.1016\/j.hoc.2015.08.003_bib107","article-title":"E1308: reduced-dose IMRT in human papillomavirus (HPV)-associated resectable oropharyngeal squamous cell carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC)","volume":"32","author":"Cmelak","year":"2014","journal-title":"J\u00a0Clin Oncol"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858815001215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858815001215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:03:36Z","timestamp":1760184216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858815001215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":107,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0889858815001215"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2015.08.003","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticipation of the Impact of Human Papillomavirus on Clinical Decision Making for the Head and Neck Cancer Patient","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2015.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}