{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:04:04Z","timestamp":1762671844409,"version":"build-2065373602"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.hoc.2015.11.001","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T23:34:10Z","timestamp":1459467250000},"page":"233-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Introduction: The Complexity and Challenge of Preventing, Treating, and Managing Blood Diseases in the\u00a0Developing Countries"],"prefix":"10.1016","volume":"30","author":[{"given":"David J.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hoc.2015.11.001_bib1","series-title":"Principles of medicine in Africa","first-page":"924","article-title":"Blood","author":"Fleming","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib2","series-title":"Oxford textbook of medicine","article-title":"Anaemia as a world health problem","author":"Roberts","year":"2015"},{"year":"2002","series-title":"World health report 2002","author":"World Health Organization","key":"10.1016\/j.hoc.2015.11.001_bib3"},{"issue":"5","key":"10.1016\/j.hoc.2015.11.001_bib4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A\u00a0systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2015.11.001_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/02724936.1993.11747637","article-title":"Seasonal variation of paediatric diseases in The Gambia, West Africa","volume":"13","author":"Brewster","year":"1993","journal-title":"Ann Trop Paediatr"},{"year":"1982","series-title":"The effects of cereals and legumes on iron availability","author":"Bothwell","key":"10.1016\/j.hoc.2015.11.001_bib6"},{"key":"10.1016\/j.hoc.2015.11.001_bib7","series-title":"World health report 2005","first-page":"45","author":"World Health Organization","year":"2005"},{"key":"10.1016\/j.hoc.2015.11.001_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0308-2261(21)00343-X","article-title":"Iron deficiency in the tropics","volume":"11","author":"Fleming","year":"1982","journal-title":"Clin Haematol"},{"key":"10.1016\/j.hoc.2015.11.001_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/00034983.1986.11812006","article-title":"The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria","volume":"80","author":"Fleming","year":"1986","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.hoc.2015.11.001_bib10","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0308-2261(21)00302-7","article-title":"Nutritional anaemias: part 2: tropical Asia","volume":"10","author":"Baker","year":"1981","journal-title":"Clin Haematol"},{"issue":"2","key":"10.1016\/j.hoc.2015.11.001_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3855\/jidc.1282","article-title":"A\u00a0perspective of the epidemiology of malaria and anaemia and their impact on maternal and perinatal outcomes in Sudan","volume":"5","author":"Adam","year":"2011","journal-title":"J\u00a0Infect Dev Ctries"},{"key":"10.1016\/j.hoc.2015.11.001_bib12","series-title":"Recent advances in haematology","first-page":"337","article-title":"Anaemia in the tropics","author":"Pitney","year":"1971"},{"issue":"1","key":"10.1016\/j.hoc.2015.11.001_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1182\/blood-2006-09-018069","article-title":"Malarial anemia: of mice and men","volume":"110","author":"Lamikanra","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.hoc.2015.11.001_bib14","series-title":"Tropical and geographic medicine","first-page":"296","article-title":"Leishmaniasis","author":"Neva","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib15","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(98)10178-2","article-title":"Leishmaniasis","volume":"354","author":"Herwaldt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.hoc.2015.11.001_bib16","series-title":"Tropical and geographic medicine","first-page":"458","article-title":"Schistosomiasis","author":"Mahmoud","year":"1989"},{"year":"1987","series-title":"Progress in assessment of morbidity due to schistosoma haematobium infection: a review of recent literature, WHO\/Schisto\/87.91","author":"World Health Organization","key":"10.1016\/j.hoc.2015.11.001_bib17"},{"key":"10.1016\/j.hoc.2015.11.001_bib18","series-title":"Tropical and geographic medicine","first-page":"245","article-title":"Malaria","author":"Miller","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","article-title":"The trypanosomiases","volume":"362","author":"Barrett","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.hoc.2015.11.001_bib20","series-title":"Tropical and geographic medicine","first-page":"379","article-title":"Hookworms","author":"Schad","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00043426-199024000-00008","article-title":"Hematologic manifestations in pediatric HIV infection: severe anemia as a prognostic factor","volume":"12","author":"Ellaurie","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.hoc.2015.11.001_bib22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1126\/science.2460922","article-title":"Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow","volume":"242","author":"Folks","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.hoc.2015.11.001_bib23","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1073\/pnas.86.14.5595","article-title":"Megakaryocytes of human immunodeficiency virus\u2013infected individuals express viral RNA","volume":"86","author":"Zucker-Franklin","year":"1989","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"10.1016\/j.hoc.2015.11.001_bib24","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0140-6736(92)91592-V","article-title":"Prognostic factors and survival in children with perinatal HIV-1 infection. The Italian register for HIV infection in children","volume":"339","author":"Tovo","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.hoc.2015.11.001_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ajh.2830290207","article-title":"Hematologic aspects of human immunodeficiency virus infection: laboratory and clinical considerations","volume":"29","author":"Perkocha","year":"1988","journal-title":"Am J Hematol"},{"key":"10.1016\/j.hoc.2015.11.001_bib26","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1651-2227.1989.tb11154.x","article-title":"Human immunodeficiency virus\u2013associated thrombocytopenia in infants","volume":"78","author":"Labrune","year":"1989","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.hoc.2015.11.001_bib27","series-title":"Tropical and geographic medicine","first-page":"65","article-title":"Eosinophilia","author":"Mahmoud","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib28","series-title":"Tropical and geographic medicine","first-page":"407","article-title":"The filariases and tropical eosinophilia","author":"Ottesen","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4269\/ajtmh.1966.15.183","article-title":"The etiology and pathology of eosinophilic lung (tropical eosinophilia)","volume":"15","author":"Danaraj","year":"1966","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.hoc.2015.11.001_bib30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.4269\/ajtmh.1962.11.646","article-title":"Occult filariasis: its relationship with tropical pulmonary eosinophilia","volume":"11","author":"Joe","year":"1962","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.hoc.2015.11.001_bib31","series-title":"Tropical and geographic medicine","first-page":"8","article-title":"Gastrointestinal manifestations","author":"Mathan","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib32","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/ajcn\/25.10.1047","article-title":"Tropical enteropathy and tropical sprue","volume":"25","author":"Baker","year":"1972","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.hoc.2015.11.001_bib33","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.26.7.710","article-title":"Rectal mucosal morphologic abnormalities in normal subjects in southern India. A tropical colonopathy","volume":"26","author":"Mathan","year":"1985","journal-title":"Gut"},{"key":"10.1016\/j.hoc.2015.11.001_bib34","series-title":"Oxford textbook of medicine","first-page":"14.112","article-title":"Malabsorption in the tropics","author":"Farthing","year":"1995"},{"key":"10.1016\/j.hoc.2015.11.001_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.7326\/0003-4819-74-2-218","article-title":"Recovery of small intestinal structure and function after residence in the tropics. I. Studies of peace corps Volunteers","volume":"74","author":"Lindenbaum","year":"1971","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hoc.2015.11.001_bib36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0016-5085(81)90025-1","article-title":"Tropical sprue in travelers and expatriates living abroad","volume":"80","author":"Klipstein","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hoc.2015.11.001_bib37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.7326\/0003-4819-64-3-575","article-title":"Tropical sprue in Haiti","volume":"64","author":"Klipstein","year":"1966","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hoc.2015.11.001_bib38","doi-asserted-by":"crossref","first-page":"632","DOI":"10.7326\/0003-4819-79-5-632","article-title":"Enterotoxigenic intestinal bacteria in tropical sprue","volume":"79","author":"Klipstein","year":"1973","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hoc.2015.11.001_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0016-5085(72)80003-9","article-title":"Bacterial flora of the gastrointestinal tract in southern Indian control subjects and patients with tropical sprue","volume":"62","author":"Bhat","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hoc.2015.11.001_bib40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(85)90122-9","article-title":"Slim disease: a new disease in Uganda and its association with HTLV-III infection","volume":"2","author":"Serwadda","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.hoc.2015.11.001_bib41","first-page":"9","article-title":"Enteropathic AIDS in Uganda: an endoscopic, histological and microbiological study","volume":"1","author":"Sewankambo","year":"1987","journal-title":"AIDS"},{"key":"10.1016\/j.hoc.2015.11.001_bib42","series-title":"Tropical and geographic medicine","first-page":"675","article-title":"Dengue","author":"Halstead","year":"1989"},{"year":"1986","series-title":"Dengue hemorrhagic fever: diagnosis, treatment and control","author":"World Health Organization","key":"10.1016\/j.hoc.2015.11.001_bib43"},{"key":"10.1016\/j.hoc.2015.11.001_bib44","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/00034983.1967.11686519","article-title":"Pathology of Thailand, haemorrhagic fever: a study of 100 autopsy cases","volume":"61","author":"Bhamarapravati","year":"1967","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.hoc.2015.11.001_bib45","first-page":"117","article-title":"Pathogenetic mechanisms in dengue haemorrhagic fever. Report of an internal collaborative study","volume":"48","year":"1973","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.hoc.2015.11.001_bib46","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI115457","article-title":"Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2 and interferon-gamma in sera of children with dengue","volume":"88","author":"Kurane","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.hoc.2015.11.001_bib47","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1086\/517807","article-title":"Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever","volume":"177","author":"Bethell","year":"1998","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib48","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/infdis\/170.5.1304","article-title":"Correlation between detection of plasminogen cross-reactive antibodies and hemorrhage in dengue virus infection","volume":"170","author":"Chungue","year":"1994","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib49","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/infdis\/164.2.294","article-title":"Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection","volume":"164","author":"Markoff","year":"1991","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib50","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/341410","article-title":"Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with dengue shock syndrome","volume":"35","author":"Wills","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib51","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa044057","article-title":"Comparison of three fluid solutions for resuscitation in dengue shock syndrome","volume":"353","author":"Wills","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.hoc.2015.11.001_bib52","series-title":"Tropical and geographic medicine","first-page":"700","article-title":"Viral hemorrhagic fevers","author":"McCormick","year":"1989"},{"key":"10.1016\/j.hoc.2015.11.001_bib53","doi-asserted-by":"crossref","first-page":"S672","DOI":"10.1093\/clinids\/11.Supplement_4.S672","article-title":"Viruses and hemostasis","volume":"11","author":"Cosgriff","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib54","series-title":"The geography of non-infectious disease","first-page":"98","author":"Hutt","year":"1986"},{"key":"10.1016\/j.hoc.2015.11.001_bib55","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/312449a0","article-title":"T-cell control of Epstein-Barr virus\u2013infected B cells is lost during P. falciparum malaria","volume":"312","author":"Whittle","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.hoc.2015.11.001_bib56","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/infdis\/147.3.406","article-title":"Epidemiology of human T-cell leukaemia\/lymphoma virus","volume":"147","author":"Blattner","year":"1983","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.hoc.2015.11.001_bib57","first-page":"343","article-title":"Primary intestinal lymphoma and its relation to alpha chain disease","volume":"11","author":"Ramot","year":"1975","journal-title":"Br J Cancer"},{"key":"10.1016\/j.hoc.2015.11.001_bib58","unstructured":"Dutz W, Borochovitz D. The two basic forms of primary intestinal lymphoma. In Proceedings of the Symposium on Prevention and Detection of Cancer. New\u00a0York, Marcel Dekker, 1980."},{"key":"10.1016\/j.hoc.2015.11.001_bib59","first-page":"37","article-title":"Hodgkin\u2019s disease in English and African children","volume":"46","author":"Burn","year":"1971","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.hoc.2015.11.001_bib60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/bjc.1982.169","article-title":"Childhood acute leukaemia in a tropical population","volume":"46","author":"Williams","year":"1982","journal-title":"Br J Cancer"},{"key":"10.1016\/j.hoc.2015.11.001_bib61","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0308-2261(21)00299-X","article-title":"Glucose-6-phosphate dehydrogenase deficiency. Part I: tropical Africa","volume":"10","author":"Bienzle","year":"1981","journal-title":"Clin Haematol"},{"key":"10.1016\/j.hoc.2015.11.001_bib62","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0308-2261(21)00300-3","article-title":"Glucose-6-phosphate dehydrogenase deficiency. Part 2: tropical Asia","volume":"10","author":"Panich","year":"1981","journal-title":"Clin Haematol"},{"key":"10.1016\/j.hoc.2015.11.001_bib63","series-title":"Paediatrics in the tropics","first-page":"13","article-title":"Neonatal jaundice","author":"Chan","year":"1981"},{"key":"10.1016\/j.hoc.2015.11.001_bib64","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4269\/ajtmh.1999.60.1056","article-title":"Prevention of cerebral malaria in children in Papua New Guinea by Southeast Asian ovalocytosis band 3","volume":"60","author":"Allen","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.hoc.2015.11.001_bib65","series-title":"Oxford textbook of medicine","first-page":"19.266","article-title":"Geographical variation in blood disease: Southeast Asia","author":"Wasi","year":"1987"},{"key":"10.1016\/j.hoc.2015.11.001_bib66","first-page":"350","article-title":"The pathogenesis of acquired prothrombin complex deficiency syndrome (APCD syndrome) in infants","volume":"10","author":"Bhanchet-Isarangkura","year":"1979","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.hoc.2015.11.001_bib67","first-page":"358","article-title":"Acquired platelet dysfunction with eosinophilia: study of platelet function in 62 cases","volume":"10","author":"Suvatte","year":"1979","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.hoc.2015.11.001_bib68","series-title":"Oxford textbook of medicine","first-page":"19.270","article-title":"Geographical variation in blood disease: India","author":"Mehta","year":"1987"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858815001884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858815001884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:02:54Z","timestamp":1760184174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858815001884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0889858815001884"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2015.11.001","relation":{},"ISSN":["0889-8588"],"issn-type":[{"type":"print","value":"0889-8588"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Introduction: The Complexity and Challenge of Preventing, Treating, and Managing Blood Diseases in the\u00a0Developing Countries","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2015.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}