{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:46:42Z","timestamp":1767912402208,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.hoc.2018.01.004","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T10:39:46Z","timestamp":1521715186000},"page":"405-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Methadone"],"prefix":"10.1016","volume":"32","author":[{"given":"Mary Lynn","family":"McPherson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C.","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra L.","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hoc.2018.01.004_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/15360288.2014.938883","article-title":"Therapeutic challenges in cancer pain management: a systematic review of methadone","volume":"28","author":"Good","year":"2014","journal-title":"J\u00a0Pain Palliat Care Pharmacother"},{"key":"10.1016\/j.hoc.2018.01.004_bib2","first-page":"493","article-title":"Vital signs: risk for overdose from methadone used for pain relief \u2013 United States, 1999-2010","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"10.1016\/j.hoc.2018.01.004_bib3","first-page":"60","article-title":"Revisiting methadone: pharmacokinetics, pharmacodynamics and clinical indication","volume":"16","author":"Neto","year":"2015","journal-title":"Rev Dor. S\u00e3o Paulo"},{"issue":"11","key":"10.1016\/j.hoc.2018.01.004_bib4","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1089\/jpm.2013.0222","article-title":"Methadone rotation for cancer patients with refractory pain in a palliative care unit: an observational study","volume":"16","author":"Rhondali","year":"2013","journal-title":"J\u00a0Palliat Med"},{"issue":"16","key":"10.1016\/j.hoc.2018.01.004_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/chir.10303","article-title":"Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19","volume":"16","author":"Gerber","year":"2004","journal-title":"Chirality"},{"key":"10.1016\/j.hoc.2018.01.004_bib6","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ejpain.2008.01.013","article-title":"Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management","volume":"12","author":"Mercadante","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.hoc.2018.01.004_bib7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1634\/theoncologist.2015-0503","article-title":"Efficacy and safety of methadone as a second-line opioid for cancer pain in an outpatient clinic: a prospective open-label study","volume":"21","author":"Porta-Sales","year":"2016","journal-title":"Oncologist"},{"key":"10.1016\/j.hoc.2018.01.004_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1089\/jpm.2016.0316","article-title":"Overall survival among cancer patients undergoing opioid rotation to methadone compared to other opioids","volume":"20","author":"Reddy","year":"2017","journal-title":"J\u00a0Palliat Med"},{"key":"10.1016\/j.hoc.2018.01.004_bib9","first-page":"321","article-title":"Methadone safety: a clinical practice guideline from the American Pain Society and College of Problems on Drug Dependence, in collaboration with the Heart Rhythm Society","volume":"15","author":"Chou","year":"2014","journal-title":"J\u00a0Pain"},{"issue":"6","key":"10.1016\/j.hoc.2018.01.004_bib10","first-page":"489","article-title":"Methadone and the QTc interval: paucity of clinically significant factors in a retrospective cohort","volume":"11","author":"Bart","year":"2017","journal-title":"J\u00a0Addict Med"},{"issue":"12","key":"10.1016\/j.hoc.2018.01.004_bib11","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1185\/03007995.2013.840568","article-title":"QT interval prolongation and the risk of torsades de pointes: essentials for clinicians","volume":"29","author":"Trinkley","year":"2013","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"10.1016\/j.hoc.2018.01.004_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/jpm.2009.0184","article-title":"The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study","volume":"13","author":"Reddy","year":"2010","journal-title":"J\u00a0Palliat Med"},{"issue":"2","key":"10.1016\/j.hoc.2018.01.004_bib13","first-page":"8","article-title":"Methadone safety guidelines for hospice and palliative care","volume":"17","author":"McPherson","year":"2016","journal-title":"AAHPM Quarterly"},{"issue":"2","key":"10.1016\/j.hoc.2018.01.004_bib14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jpainsymman.2015.02.029","article-title":"Methods of rotation from another strong opioid to methadone for the management of cancer pain: a systematic review of the available evidence","volume":"50","author":"McLean","year":"2015","journal-title":"J\u00a0Pain Symptom Manage"},{"issue":"5","key":"10.1016\/j.hoc.2018.01.004_bib15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1526-4637.2008.00461.x","article-title":"A\u00a0systematic review of opioid conversion ratios used with methadone for the treatment of pain","volume":"9","author":"Weschules","year":"2008","journal-title":"Pain Med"},{"issue":"3","key":"10.1016\/j.hoc.2018.01.004_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/jpm.2012.0335","article-title":"Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series","volume":"16","author":"Wallace","year":"2013","journal-title":"J\u00a0Palliat Med"},{"issue":"6","key":"10.1016\/j.hoc.2018.01.004_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jpm.2012.0612","article-title":"The use of very-low-dose methadone for palliative pain control and the prevention of opioid hyperalgesia","volume":"16","author":"Salpeter","year":"2013","journal-title":"J\u00a0Palliat Med"},{"issue":"2","key":"10.1016\/j.hoc.2018.01.004_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/jpm.2014.0266","article-title":"The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report","volume":"18","author":"Salpeter","year":"2015","journal-title":"J\u00a0Palliat Med"},{"issue":"9","key":"10.1016\/j.hoc.2018.01.004_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jpm.2015.0525","article-title":"Methadone as a coanalgesic for palliative care cancer patients","volume":"19","author":"Courtemanche","year":"2016","journal-title":"J\u00a0Palliat Med"},{"key":"10.1016\/j.hoc.2018.01.004_bib20","unstructured":"U.S. Food & Drug Administration. FDA Drug Safety Communication: FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning. 2016. Available at: https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm518473.htm. Accessed October 15, 2017."},{"key":"10.1016\/j.hoc.2018.01.004_bib21","unstructured":"Credible Meds. Available at: https:\/\/crediblemeds.org\/. Accessed October 15, 2017."},{"key":"10.1016\/j.hoc.2018.01.004_bib22","unstructured":"Methadone. Micromedex solutions. Ann Arbor (MI): Truven Health Analytics, Inc. Available at: http:\/\/www.micromedexsolutions.com. Accessed October 10, 2017."},{"key":"10.1016\/j.hoc.2018.01.004_bib23","unstructured":"Nova Scotia Health Authority. Using methadone for chronic pain: patient & family guide. 2017. Available at: https:\/\/www.cdha.nshealth.ca\/patientinformation\/nshealthnet\/0686.pdf. Accessed October 8, 2017."},{"key":"10.1016\/j.hoc.2018.01.004_bib24","unstructured":"VA National Pain Management Program. Available at: https:\/\/www.ethics.va.gov\/docs\/policy\/Taking_Opioids_Responsibly_2013528.pdf. Accessed October 10, 2017."},{"key":"10.1016\/j.hoc.2018.01.004_bib25","series-title":"Methadone safety handout for patients","author":"Leavitt","year":"2008"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858818300145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858818300145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:05:24Z","timestamp":1760184324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858818300145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0889858818300145"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2018.01.004","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methadone","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2018.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}