{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:42:22Z","timestamp":1792190542896,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Reproductive Scientist Development Program","award":["K12-18-013"],"award-info":[{"award-number":["K12-18-013"]}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Gynecologic Oncology Group"},{"name":"the Honorable Tina Brozman Foundation"},{"name":"the Minnesota Ovarian Cancer Alliance"},{"name":"the Robert and Deborah First Family Fund"},{"name":"the Saltonstall Research Fund"},{"name":"the Potter Research Fund"},{"name":"the Partners Healthcare Innovation Discovery Grant Program"},{"name":"the BWH Ovarian Cancer Research Fund"},{"name":"Early Detection Research Network","award":["5\u00a0U01 CA200462-02"],"award-info":[{"award-number":["5\u00a0U01 CA200462-02"]}]},{"name":"MD Anderson Ovarian SPORE","award":["P50 CA83639"],"award-info":[{"award-number":["P50 CA83639"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012737","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"the Cancer Prevention Research Institute of Texas","doi-asserted-by":"crossref","award":["RP160145"],"award-info":[{"award-number":["RP160145"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006784","name":"Golfers Against Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006784","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mossy Foundation"},{"name":"Roberson Endowment"},{"DOI":"10.13039\/100001767","name":"the National Foundation for Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001767","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014400","name":"Fujirebio Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014400","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.hoc.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T09:39:48Z","timestamp":1538127588000},"page":"903-914","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":177,"title":["Early Detection of Ovarian Cancer"],"prefix":"10.1016","volume":"32","author":[{"given":"Kevin M.","family":"Elias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert C.","family":"Bast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib1","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"4\u20135","key":"10.1016\/j.hoc.2018.07.003_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0895-4356(91)90075-K","article-title":"Quantifying the potential benefit of CA 125 screening for ovarian cancer","volume":"44","author":"Skates","year":"1991","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/jamaoncol.2017.4211","article-title":"Estimating cost-effectiveness of a multimodal ovarian cancer screening program in the United States: secondary analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)","volume":"4","author":"Moss","year":"2018","journal-title":"JAMA Oncol"},{"issue":"6","key":"10.1016\/j.hoc.2018.07.003_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/jama.2017.21421","article-title":"Screening for ovarian cancer: updated evidence report and systematic review for the US preventive services task force","volume":"319","author":"Henderson","year":"2018","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.hoc.2018.07.003_bib5","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.suc.2015.05.009","article-title":"Principles of cancer screening","volume":"95","author":"Pinsky","year":"2015","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.hoc.2018.07.003_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.canep.2016.12.004","article-title":"Assessment of lead-time bias in estimates of relative survival for breast cancer","volume":"46","author":"Andersson","year":"2017","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.1016\/j.hoc.2018.07.003_bib7","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ajog.2005.05.005","article-title":"Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial","volume":"193","author":"Buys","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ygyno.2016.08.334","article-title":"Extended mortality results for ovarian cancer screening in the PLCO trial with median 15years follow-up","volume":"143","author":"Pinsky","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"454","key":"10.1016\/j.hoc.2018.07.003_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1198\/016214501753168145","article-title":"Screening based on the risk of cancer calculation from bayesian hierarchical changepoint and mixture models of longitudinal markers","volume":"96","author":"Skates","year":"2001","journal-title":"J\u00a0Am Stat Assoc"},{"issue":"Suppl 1","key":"10.1016\/j.hoc.2018.07.003_bib10","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/IGC.0b013e318256488a","article-title":"Ovarian cancer screening: development of the risk of ovarian cancer algorithm (ROCA) and ROCA screening trials","volume":"22","author":"Skates","year":"2012","journal-title":"Int J Gynecol Cancer"},{"issue":"19","key":"10.1016\/j.hoc.2018.07.003_bib11","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1002\/cncr.28183","article-title":"A\u00a02-stage ovarian cancer screening strategy using the Risk of Ovarian Cancer Algorithm (ROCA) identifies early-stage incident cancers and demonstrates high positive predictive value","volume":"119","author":"Lu","year":"2013","journal-title":"Cancer"},{"issue":"10022","key":"10.1016\/j.hoc.2018.07.003_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(15)01224-6","article-title":"Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","volume":"387","author":"Jacobs","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.hoc.2018.07.003_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jama.2017.21926","article-title":"Screening for ovarian cancer: US preventive services task force recommendation statement","volume":"319","author":"US Preventive Services Task Force","year":"2018","journal-title":"JAMA"},{"issue":"suppl 5","key":"10.1016\/j.hoc.2018.07.003_bib14","doi-asserted-by":"crossref","first-page":"v103","DOI":"10.1093\/annonc\/mdw327","article-title":"Prevention and screening in BRCA mutation carriers and other breast\/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening","volume":"27","author":"Paluch-Shimon","year":"2016","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1158\/1055-9965.EPI-07-2703","article-title":"A\u00a0prospective study of risk-reducing salpingo-oophorectomy and longitudinal CA-125 screening among women at increased genetic risk of ovarian cancer: design and baseline characteristics: a Gynecologic Oncology Group study","volume":"17","author":"Greene","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"13","key":"10.1016\/j.hoc.2018.07.003_bib16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1200\/JCO.2016.69.9330","article-title":"Evidence of stage shift in women diagnosed with ovarian cancer during phase II of the United Kingdom Familial Ovarian Cancer Screening Study","volume":"35","author":"Rosenthal","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"issue":"15","key":"10.1016\/j.hoc.2018.07.003_bib17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM198310133091503","article-title":"A\u00a0radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer","volume":"309","author":"Bast","year":"1983","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.hoc.2018.07.003_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/14737159.2017.1326820","article-title":"The role of biomarkers in the management of epithelial ovarian cancer","volume":"17","author":"Yang","year":"2017","journal-title":"Expert Rev Mol Diagn"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1158\/1940-6207.CAPR-10-0195","article-title":"Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens","volume":"4","author":"Cramer","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"issue":"18","key":"10.1016\/j.hoc.2018.07.003_bib20","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1158\/1078-0432.CCR-16-0316","article-title":"A\u00a0prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort","volume":"22","author":"Terry","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"7353","key":"10.1016\/j.hoc.2018.07.003_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.hoc.2018.07.003_bib22","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1158\/1078-0432.CCR-17-0284","article-title":"Elevation of TP53 autoantibody before CA125 in preclinical invasive epithelial ovarian cancer","volume":"23","author":"Yang","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ijc.31335","article-title":"Tumor-associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation","volume":"143","author":"Kaaks","year":"2018","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ygyno.2017.07.138","article-title":"Systematic review: tumor-associated antigen autoantibodies and ovarian cancer early detection","volume":"147","author":"Fortner","year":"2017","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.hoc.2018.07.003_bib25","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1373\/clinchem.2010.144188","article-title":"Analysis of the size distributions of fetal and maternal cell-free DNA by paired-end sequencing","volume":"56","author":"Fan","year":"2010","journal-title":"Clin Chem"},{"issue":"15","key":"10.1016\/j.hoc.2018.07.003_bib26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.clinbiochem.2015.04.005","article-title":"The translational potential of circulating tumour DNA in oncology","volume":"48","author":"Patel","year":"2015","journal-title":"Clin Biochem"},{"issue":"4","key":"10.1016\/j.hoc.2018.07.003_bib27","first-page":"1659","article-title":"DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells","volume":"61","author":"Jahr","year":"2001","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.hoc.2018.07.003_bib28","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1373\/clinchem.2008.104612","article-title":"Preferential amplification of apoptotic DNA from plasma: potential for enhancing detection of minor DNA alterations in circulating DNA","volume":"54","author":"Mamon","year":"2008","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bioinformatics\/btw536","article-title":"SiNVICT: ultra-sensitive detection of single nucleotide variants and indels in circulating tumour DNA","volume":"33","author":"Kockan","year":"2017","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.hoc.2018.07.003_bib30","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1158\/1078-0432.CCR-15-2470","article-title":"Circulating cell-free tumor DNA analysis of 50 genes by next-generation sequencing in the prospective MOSCATO trial","volume":"22","author":"Jovelet","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1016\/j.hoc.2018.07.003_bib31","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1158\/1078-0432.CCR-13-2933","article-title":"Detection of cancer DNA in plasma of patients with early-stage breast cancer","volume":"20","author":"Beaver","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/10408363.2017.1299683","article-title":"Using circulating cell-free DNA to monitor personalized cancer therapy","volume":"54","author":"Oellerich","year":"2017","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"9","key":"10.1016\/j.hoc.2018.07.003_bib33","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1158\/1078-0432.CCR-16-1078","article-title":"Chromosomal instability in cell-free DNA as a highly specific biomarker for detection of ovarian cancer in women with adnexal masses","volume":"23","author":"Vanderstichele","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"3 Pt 1","key":"10.1016\/j.hoc.2018.07.003_bib34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ajog.2005.01.054","article-title":"Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer","volume":"193","author":"Swisher","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"136","key":"10.1016\/j.hoc.2018.07.003_bib35","doi-asserted-by":"crossref","first-page":"136ra168","DOI":"10.1126\/scitranslmed.3003726","article-title":"Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA","volume":"4","author":"Forshew","year":"2012","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib36","doi-asserted-by":"crossref","first-page":"e0194630","DOI":"10.1371\/journal.pone.0194630","article-title":"Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA","volume":"13","author":"Gale","year":"2018","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.hoc.2018.07.003_bib37","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1073\/pnas.1601311113","article-title":"Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues","volume":"113","author":"Krimmel","year":"2016","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ygyno.2008.01.012","article-title":"A\u00a0candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations","volume":"109","author":"Folkins","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"6378","key":"10.1016\/j.hoc.2018.07.003_bib39","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.aar3247","article-title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","volume":"359","author":"Cohen","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.hoc.2018.07.003_bib40","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","article-title":"Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors","volume":"92","author":"Esteller","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib41","first-page":"681","article-title":"Frequent SLIT2 promoter methylation in the serum of patients with ovarian cancer","volume":"40","author":"Dong","year":"2012","journal-title":"J\u00a0Int Med Res"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/mmr.2014.2221","article-title":"DNA methylation profiles in ovarian cancer: implication in diagnosis and therapy","volume":"10","author":"Koukoura","year":"2014","journal-title":"Mol Med Rep"},{"issue":"18","key":"10.1016\/j.hoc.2018.07.003_bib43","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"5","key":"10.1016\/j.hoc.2018.07.003_bib44","first-page":"759","article-title":"Detection of circulating methylated opioid binding protein\/cell adhesion molecule-like gene as a biomarker for ovarian carcinoma","volume":"60","author":"Zhou","year":"2014","journal-title":"Clin Lab"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ygyno.2013.04.048","article-title":"A\u00a0multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA","volume":"130","author":"Zhang","year":"2013","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib46","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13073-017-0500-7","article-title":"The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer","volume":"9","author":"Widschwendter","year":"2017","journal-title":"Genome Med"},{"issue":"2","key":"10.1016\/j.hoc.2018.07.003_bib47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.hoc.2018.07.003_bib48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrg3198","article-title":"MicroRNA profiling: approaches and considerations","volume":"13","author":"Pritchard","year":"2012","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-016-0536-0","article-title":"Clinical relevance of circulating cell-free microRNAs in ovarian cancer","volume":"15","author":"Nakamura","year":"2016","journal-title":"Mol Cancer"},{"issue":"30","key":"10.1016\/j.hoc.2018.07.003_bib50","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"52","key":"10.1016\/j.hoc.2018.07.003_bib51","doi-asserted-by":"crossref","first-page":"89811","DOI":"10.18632\/oncotarget.20688","article-title":"A\u00a0combination of circulating miRNAs for the early detection of ovarian cancer","volume":"8","author":"Yokoi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.hoc.2018.07.003_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28932","article-title":"Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer","volume":"6","author":"Elias","year":"2017","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.hoc.2018.07.003_bib53","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/AOG.0000000000000484","article-title":"Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer","volume":"124","author":"Erickson","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"36","key":"10.1016\/j.hoc.2018.07.003_bib54","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1200\/JCO.2015.61.3083","article-title":"Lavage of the uterine cavity for molecular detection of mullerian duct carcinomas: a proof-of-concept study","volume":"33","author":"Maritschnegg","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"433","key":"10.1016\/j.hoc.2018.07.003_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aap8793","article-title":"Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers","volume":"10","author":"Wang","year":"2018","journal-title":"Sci Transl Med"},{"issue":"34","key":"10.1016\/j.hoc.2018.07.003_bib56","doi-asserted-by":"crossref","DOI":"10.3310\/hta8340","article-title":"Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status","volume":"8","author":"Critchley","year":"2004","journal-title":"Health Technol Assess"},{"issue":"1","key":"10.1016\/j.hoc.2018.07.003_bib57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0090-8258(03)00414-1","article-title":"Preoperative differentiation of malignant from benign ovarian tumors: the efficacy of morphology indexing and Doppler flow sonography","volume":"91","author":"Ueland","year":"2003","journal-title":"Gynecol Oncol"},{"issue":"198","key":"10.1016\/j.hoc.2018.07.003_bib58","doi-asserted-by":"crossref","first-page":"198ra108","DOI":"10.1126\/scitranslmed.3006070","article-title":"Metabolic imaging of patients with prostate cancer using hyperpolarized [1-(1)(3)C]pyruvate","volume":"5","author":"Nelson","year":"2013","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.hoc.2018.07.003_bib59","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1088\/0031-9155\/50\/6\/016","article-title":"A\u00a0biomagnetic system for in\u00a0vivo cancer imaging","volume":"50","author":"Flynn","year":"2005","journal-title":"Phys Med Biol"},{"issue":"3","key":"10.1016\/j.hoc.2018.07.003_bib60","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/cmmi.499","article-title":"Imaging of Her2-targeted magnetic nanoparticles for breast cancer detection: comparison of SQUID-detected magnetic relaxometry and MRI","volume":"7","author":"Adolphi","year":"2012","journal-title":"Contrast Media Mol Imaging"},{"issue":"21","key":"10.1016\/j.hoc.2018.07.003_bib61","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1158\/0008-5472.CAN-09-1083","article-title":"Enhanced leukemia cell detection using a novel magnetic needle and nanoparticles","volume":"69","author":"Jaetao","year":"2009","journal-title":"Cancer Res"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858818307536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858818307536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:11:17Z","timestamp":1760184677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858818307536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0889858818307536"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2018.07.003","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Detection of Ovarian Cancer","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}