{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:59:41Z","timestamp":1787507981476,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.hoc.2020.08.004","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T05:32:34Z","timestamp":1601443954000},"page":"1099-1113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Systemic Amyloidosis Caused by Monoclonal Immunoglobulins"],"prefix":"10.1016","volume":"34","author":[{"given":"James E.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi G.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Sanchorawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"319","key":"10.1016\/j.hoc.2020.08.004_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ajh.20381","article-title":"Definition of Organ Involvement and Treatment Response in Immunoglobulin Light Chain Amyloidosis (AL): A Consensus Opinion From the 10th International Symposium on Amyloid in Amyloidosis","volume":"79","author":"Gertz","year":"2005","journal-title":"Am J Hematol"},{"issue":"11","key":"10.1016\/j.hoc.2020.08.004_bib2","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1002\/art.22959","article-title":"Soft Tissue, Joint, and Bone Manifestations of AL Amyloidosis","volume":"56","author":"Prokaeva","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.hoc.2020.08.004_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13506129.2011.571319","article-title":"Myocardial infarction with 'clean coronaries' caused by light-chain AL amyloidosis: a case report and literature review","volume":"18","author":"Tsai","year":"2011","journal-title":"Amyloid"},{"key":"10.1016\/j.hoc.2020.08.004_bib4","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.joms.2009.04.036","article-title":"Rational Management of Macroglossia Due to Acquired Systemic Amyloidosis: Does Surgery Play a Role?","volume":"67","author":"Guijarro-Martinez","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.hoc.2020.08.004_bib5","first-page":"396","article-title":"Amyloidosis as a Systemic Disease in Context","volume":"36","author":"Cuddy","year":"2020","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.hoc.2020.08.004_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/13506129.2011.560217","article-title":"Macroglossia - not always AL amyloidosis","volume":"18","author":"Cowan","year":"2011","journal-title":"Amyloid"},{"key":"10.1016\/j.hoc.2020.08.004_bib7","first-page":"3009","article-title":"Amyloid Deposition in the Tongue: Clinical and Histopathological Profile","volume":"30","author":"Angiero","year":"2010","journal-title":"Anticancer Res"},{"issue":"4","key":"10.1016\/j.hoc.2020.08.004_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00005792-197507000-00001","article-title":"Amyloidosis: Review of 236 Cases","volume":"51","author":"Kyle","year":"1975","journal-title":"Medicine"},{"key":"10.1016\/j.hoc.2020.08.004_bib9","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1600-0714.1988.tb01333.x","article-title":"Multiple myeloma and amyloidosis of the tongue","volume":"17","author":"Raubenheimer","year":"1988","journal-title":"J\u00a0Oral Pathol"},{"key":"10.1016\/j.hoc.2020.08.004_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.oraloncology.2005.09.010","article-title":"Head and neck amyloidosis: A clinicopathologic study of 15 cases","volume":"42","author":"Penner","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.hoc.2020.08.004_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0030-4220(94)90272-0","article-title":"Tongue, primary amyloidosis, and multiple myeloma","volume":"77","author":"Reinish","year":"1994","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.hoc.2020.08.004_bib12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1159\/000330238","article-title":"Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy","volume":"4","author":"Thibault","year":"2011","journal-title":"Case Rep Oncol"},{"key":"10.1016\/j.hoc.2020.08.004_bib13","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/j.bjoms.2012.04.258","article-title":"The surgical management of severe macroglossia in systemic AL amyloidosis","volume":"51","author":"Cobb","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.hoc.2020.08.004_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1875-595X.2011.00015.x","article-title":"Macroglossia","volume":"61","author":"Topouzelis","year":"2011","journal-title":"Int Dent J"},{"key":"10.1016\/j.hoc.2020.08.004_bib15","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1186\/s13256-018-1760-6","article-title":"Exceptional mucocutaneous manifestations with amyloid nephropathy: a case report","volume":"12","author":"Yoon","year":"2018","journal-title":"J\u00a0Med Case Rep"},{"key":"10.1016\/j.hoc.2020.08.004_bib16","article-title":"Comparison of Ultrasound Features of Major Salivary Glands in Sarcoidosis, Amyloidosis, and Sj\u00f6gren\u2019s syndrome","author":"Law","year":"2019","journal-title":"Arthritis Care Res"},{"issue":"4","key":"10.1016\/j.hoc.2020.08.004_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/art.1780300409","article-title":"Synovial Fluid Analysis for Diagnosis of Amyloid Arthropathy","volume":"30","author":"Lakhanpal","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.hoc.2020.08.004_bib18","first-page":"1473","article-title":"Amyloid Arthropathy in the Course of Multiple Myeloma","volume":"29","author":"Fautrel","year":"2002","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.hoc.2020.08.004_bib19","first-page":"665","article-title":"Amyloidosis (AL): Clinical and Laboratory Features in 229 cases","volume":"58","author":"Kyle","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.hoc.2020.08.004_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.semarthrit.2013.07.004","article-title":"Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases","volume":"43","author":"Elsaman","year":"2013","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.hoc.2020.08.004_bib21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00005792-197211000-00003","article-title":"Amyloid Joint Disease","volume":"51","author":"Wiernik","year":"1972","journal-title":"Medicine"},{"key":"10.1016\/j.hoc.2020.08.004_bib22","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies","author":"Milandri","year":"2019","journal-title":"Eur Soc Cardiol"},{"issue":"17","key":"10.1016\/j.hoc.2020.08.004_bib23","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jacc.2018.07.092","article-title":"Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release","volume":"72","author":"Sperry","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.hoc.2020.08.004_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jhsa.2019.06.016","article-title":"Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis","volume":"44","author":"Donnelly","year":"2019","journal-title":"J\u00a0Hand Surg Am"},{"key":"10.1016\/j.hoc.2020.08.004_bib25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1136\/jnnp.60.6.655","article-title":"Myopathy in primary systemic amyloidosis","volume":"60","author":"Gertz","year":"1996","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.hoc.2020.08.004_bib26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1046\/j.1365-3083.2001.00980.x","article-title":"Shoulder-Pad Sign of Amyloidosis: Structure of an Ig Kappa III Protein","volume":"54","author":"Liepnieks","year":"2001","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.hoc.2020.08.004_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13506120500221799","article-title":"Diaphragm paralysis in primary systemic amyloidosis","volume":"12","author":"Berk","year":"2005","journal-title":"Amyloid"},{"issue":"10","key":"10.1016\/j.hoc.2020.08.004_bib28","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.mayocp.2016.06.027","article-title":"Systemic Immunoglobulin Light Chain Amyloidosis-Associated Myopathy: Presentation, Diagnostic Pitfalls, and Outcome","volume":"91","author":"Muchtar","year":"2016","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"10.1016\/j.hoc.2020.08.004_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(88)70001-8","article-title":"Amyloid and Amyloidosis","volume":"18","author":"Breathnach","year":"1988","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.hoc.2020.08.004_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/13506129.2016.1183477","article-title":"Penile ulcers complicating systemic AL amyloidosis: a case report","volume":"23","author":"Arun","year":"2016","journal-title":"Amyloid"},{"issue":"12","key":"10.1016\/j.hoc.2020.08.004_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D31912020711","article-title":"Primary localized cutaneous amyloidosis","volume":"19","author":"Terushkin","year":"2013","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.hoc.2020.08.004_bib32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/eurheartj\/ehm066","article-title":"Vascular abnormalities in primary amyloidosis","volume":"28","author":"Modesto","year":"2007","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.hoc.2020.08.004_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/1054-8807(94)00023-K","article-title":"Amyloidosis and Endomyocardial Biopsy: Correlation of Extent and Pattern of Deposition with Amyloid Immunophenotype in 100 Cases","volume":"4","author":"Crotty","year":"1995","journal-title":"Cardiovasc Pathol"},{"issue":"6","key":"10.1016\/j.hoc.2020.08.004_bib34","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1213\/01.ane.0000290304.02125.6e","article-title":"Periorbital Ecchymoses During General Anesthesia in a Patient with Primary Amyloidosis: A Harbinger for Bleeding?","volume":"105","author":"Weingarten","year":"2007","journal-title":"Anesth Analg"},{"issue":"2","key":"10.1016\/j.hoc.2020.08.004_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0037-198X(86)90030-1","article-title":"Amyloidosis and Plasma Cell Dyscrasias of the Musculoskeletal System","volume":"21","author":"Subbarao","year":"1986","journal-title":"Semin Roentgenol"},{"key":"10.1016\/j.hoc.2020.08.004_bib36","first-page":"2283","article-title":"Jaw Claudication in Primary Amyloidosis: Unusual Presentation of a Rare Disease","volume":"30","author":"Churchill","year":"2003","journal-title":"J\u00a0Rheumatol"},{"issue":"11","key":"10.1016\/j.hoc.2020.08.004_bib37","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/art.1780371111","article-title":"Primary Systemic Amyloidosis Presenting as Giant Cell Arteritis and Polymyalgia Rheumatica","volume":"37","author":"Salvarani","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.hoc.2020.08.004_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-9149(79)90389-8","article-title":"Ischemic Heart Disease Secondary to Amyloidosis of Intramyocardial Arteries","volume":"44","author":"Smith","year":"1979","journal-title":"Am J Cardiol"},{"issue":"11","key":"10.1016\/j.hoc.2020.08.004_bib39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.7326\/0003-4819-131-11-199912070-00007","article-title":"Systemic Amyloidosis Presenting with Angina Pectoris","volume":"131","author":"Al Suwaidi","year":"1999","journal-title":"Ann Intern Med"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088985882030099X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088985882030099X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:15:00Z","timestamp":1760184900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088985882030099X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S088985882030099X"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2020.08.004","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Amyloidosis Caused by Monoclonal Immunoglobulins","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2020.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}